Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	TRIM9
Symbol Alias	SPRING, RNF91
Approved Name	tripartite motif containing 9
Previous Name	tripartite motif-containing 9
Location	14q21.3
Position	chr14:50975262-51096061, -1
External Links	HGNC: 16288 Entrez Gene: 114088 Ensembl: ENSG00000100505 UCSC: uc001wyx.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P.,2011	SNP: rs8006348	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016874	ligase activity	molecular function	IEA	16
GO:0030425	dendrite	cellular component	IDA[20085810]	65
GO:0000149	SNARE binding	molecular function	IEA	7
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IDA[20085810]	13
GO:0045955	negative regulation of calcium ion-dependent exocytosis	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA[11331580]	322
GO:0016567	protein ubiquitination	biological process	IEA	18
GO:0008021	synaptic vesicle	cellular component	IEA	13
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0004842	ubiquitin-protein transferase activity	molecular function	IDA[20085810]	12
GO:0030054	cell junction	cellular component	IEA	88
GO:0042803	protein homodimerization activity	molecular function	IPI[11331580]	71
GO:0035544	negative regulation of SNARE complex assembly	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0016079	synaptic vesicle exocytosis	biological process	IEA	4
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRIM9	BTRC	NO	yeast 2-hybrid	16189514
TRIM9	VASP	NO	yeast 2-hybrid	16189514
TRIM9	NCF1	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs8006348	chr14:51058755 - 51058755(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs12588907	chr14:51058456 - 51058456(1)	intron_variant
rs8006878	chr14:51058968 - 51058968(1)	intron_variant
rs4480710	chr14:51059365 - 51059365(1)	intron_variant
rs4901075	chr14:51056701 - 51056701(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q22-24	chr14:50400000-78800000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q22	chr14:50400000-57600000	1 (0/1/0)
14q12-q22.3	chr14:24100000-57600000	1 (1/0/0)
14q13.1-q24.1	chr14:32900000-69800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr14:50975262..51096061 View in gBrowse