Gene Report

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Basic Info

Approved Symbol	ZFYVE21
Symbol Alias	MGC2550, ZF21
Approved Name	zinc finger, FYVE domain containing 21
Location	14q32.33
Position	chr14:103715730-103733668, 1
External Links	HGNC: 20760 Entrez Gene: 79038 Ensembl: ENSG00000100711 UCSC: uc001yod.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs8548	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005768	endosome	cellular component	IEA	27
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IEA	16
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005925	focal adhesion	cellular component	IEA	32
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs8548	chr14:103733243 - 103733243(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:103715730..103733668 View in gBrowse