BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Grigoroiu-Serbanescu, M.,2010 PMID: 20230869
Citation	Grigoroiu-Serbanescu, M., S. Herms, et al. (2010). "Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients." Prog Neuropsychopharmacol Biol Psychiatry 34(4): 657-663.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	198 BPI patients and 180 controls
SNP/Region/Marker Size	12 SNPs
Predominant Ethnicity	Caucasian
Population	Romanian
Gender	57.9% female in BPI sample,60% female in controls
Age Group	Adults : The mean age at interview of the total BPI sample was 41.11 years (SD=13.48, median=43). The mean age at onset was 26.45 years (SD=9.94, median=24). The mean age at interview of the total control sample was 41.29 years (SD=12.31) (median=42).

Detail Info

Sample Diagnosis	DSM
Sample Status	The patients were recruited in the Obregia Psychiatric Hospital of Bucharest, a large state university hospital. Written informed consent was obtained from all subjects involved in the study and the ethical standards of the research project were approved by the Grant Committee of the Romanian Ministry for Education and Research, as well as by the ethical commission of the Obregia Psychiatric Hospital. The patient sample included 198 unrelated BPI patients recruited from consecutive hospital admissions. All patients had a history of at least two hospitalized illness episodes (one manic/mixed and one depressive or two manic episodes). The hospitalization criterion ensured a more uniform illness severity of the sample. The mean number of hospitalized episodes per patient was 6.49 (SD=4.22,range 2-28).We screened 190 unrelated individuals of Romanian origin for the presence of major affective disorders, SA, SZ or other psychosis, obsessive-compulsive disorder, eating disorders, alcohol or drug addiction. We selected the controls from the general population after conducting a genealogical investigation to the grand-parental generation.We retained 180 controls for this study. Controls were administered the DIGS and the FIGS interviews under the same diagnostic and ethical standards as those used for patients.Controls were matched with the patients with respect to gender and chronological age within an allowed maximum 5-year difference. This was not significantly different from the sex distribution of the patient sample that included 114 (57.9%)females and 84 (42.1%) males (_2=0.383, df=1, P=0.536).
Technique	genotyping
Statistical Method	Single-marker and haplotype association analyses were performed using the FAMHAP software (http://famhap.meb.uni-bonn.de) (Becker and Knapp, 2004; Becker et al., 2005; Herold and Becker,2009).FAMHAP uses the Cochrane-Armitage trend test for allelic association and incorporates the HWE when computing the significance of the association with the disease.The genotypic association is computed through a likelihood ratio test based on the expectation-maximization algorithm (EM). Haplotype frequencies are estimated based on maximum likelihood tests and Monte Carlo simulations allow for multiple comparison adjustment (Becker et al., 2005).
Result Summary	RESULTS: No significant difference was found in the allele distribution of those repeats between bipolar patients and controls. Ligation product size in RED was not increased in bipolar patients. However, the copy number of ligation product in RED was highly correlated with CAG/CTG copies of ERDA1 (P=0.0001), partly with CTG 18.1 (P=0.04), but not with KCNN3. CONCLUSIONS: A longer CAG repeat alleles of KCNN3 or CTG 18.1 may not be a risk factor for BPAD in Korean population and the copy number of ligation product in RED in the patients with BPAD is influenced by the longer allele of CAG/CTG of ERDA1 or CTG 18.1.

SNPs reported by this study for BD (count: 13)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs778294	DAOA DAOA-AS1	C/T		Allelic association analysis: for non-psychotic patients, P-value = 0.286, OR(95%CI)=0.68(0.34-1.38); for psychotic patients, P-value = 0.3657, OR(95%CI)=1.16(0.83-1.63)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs954581	DAOA-AS1 DAOA	A/G		Allelic association analysis: for non-psychotic patients, P-value = 0.733, OR(95%CI)=0.84(0.34-2.09; for psychotic patients, P-value = 0.694, OR(95%CI)=0.91(0.58-1.44)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1935062	DAOA DAOA-AS1	A/C		Allelic association analysis: for non-psychotic patients, P-value = 0.115, OR(95%CI)=1.63(0.90-2.92); for psychotic patients, P-value = 0.657, OR(95%CI)=0.93(0.68-1.27)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2391191	DAOA DAOA-AS1	G/A		Allelic association analysis: for non-psychotic patients, P-value = 0.043, OR(95%CI)=1.82(1.01-3.28); for psychotic patients, P-value = 0.517, OR(95%CI)=0.9(0.66-1.24)	Significant association was found in non-psychotic BP-I pati...... Significant association was found in non-psychotic BP-I patients. More...	Positive
rs3916965	DAOA	G/A		Allelic association analysis: for non-psychotic patients, P-value = 0.044, OR(95%CI)=1.82(1.01-3.28); for psychotic patients, P-value = 0.517, OR(95%CI)=0.9(0.66-1.24)	Significant association was found in non-psychotic BP-I pati...... Significant association was found in non-psychotic BP-I patients. More...	Positive
rs3916967	DAOA DAOA-AS1	A/G		Allelic association analysis: for non-psychotic patients, P-value = 0.043, OR(95%CI)=1.82(1.01-3.28); for psychotic patients, P-value = 0.517, OR(95%CI)=0.9(0.66-1.24)	Significant association was found in non-psychotic BP-I pati...... Significant association was found in non-psychotic BP-I patients. More...	Positive
rs3916971	DAOA-AS1 DAOA	C/T		Allelic association analysis: for non-psychotic patients, P-value = 0.112, OR(95%CI)=1.64(0.91-2.98); for psychotic patients, P-value = 0.579, OR(95%CI)=0.91(0.67-1.24)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3918342	DAOA	T/C		Allelic association analysis: for non-psychotic patients, P-value = 0.116, OR(95%CI)=1.57(0.87-2.84); for psychotic patients, P-value = 0.847, OR(95%CI)=0.97(0.71-1.32)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs67705083	DAOA DAOA-AS1	C/A		Allelic association analysis: for non-psychotic patients, P-value = 0.339, OR(95%CI)=0.73(0.37-1.39); for psychotic patients, P-value = 0.556, OR(95%CI)=1.1(0.80-1.52)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs778293	DAOA	A/G		Allelic association analysis: for non-psychotic patients, P-value = 0.802, OR(95%CI)=1.08(0.60-1.93); for psychotic patients, P-value = 0.604, OR(95%CI)=0.92(0.67-1.25)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1341402	DAOA DAOA-AS1	T/C		Allelic association analysis: for non-psychotic patients, P-value = 0.294, OR(95%CI)=0.68(0.33-1.42); for psychotic patients, P-value = 0.934, OR(95%CI)=0.99(0.70-1.40)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1935057	DAOA-AS1 DAOA	A/G		Allelic association analysis: for non-psychotic patients, P-value = 0.037, OR(95%CI)=1.88(1.04-3.40); for psychotic patients, P-value = 0.579, OR(95%CI)=0.92(0.68-1.25)	Significant association was found in non-psychotic BP-I pati...... Significant association was found in non-psychotic BP-I patients. More...	Positive
rs1421292	DAOA	T/A		Allelic association analysis: for non-psychotic patients, P-value = 0.342, OR(95%CI)=0.75(0.42-1.37); for psychotic patients, P-value = 0.598, OR(95%CI)=1.09(0.80-1.47)	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs3916967 - rs2391191		DAOA	Haplotype analysis:for non-psychotic patients, global P-value = 0.0524 (corrected value in 100, 000 permutations)	Significant association was found in non-psychotic BP-I pati...... Significant association was found in non-psychotic BP-I patients. More...	Positive

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
DAOA z6:1117	DAOA	point mutation	A/G		Allelic association analysis:for non-psychotic patients, P-value = 0.249, OR(95%CI)=1.92(0.61-6.06);for psychotic patients, P-value = 0.92, OR(95%CI)=1.04(0.48-2.22)	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)