Study Report
Basic Info
| Reference |
Dalvie, S.,2010 PMID: 20957330
|
| Citation |
Dalvie, S., N. Horn, et al. (2010). "Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype." Afr J Psychiatry (Johannesbg) 13(4): 297-301.
|
| Disease Type |
Bipolar I Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
132 cases; 188 controls |
| SNP/Region/Marker Size |
3 SNPs |
| Predominant Ethnicity |
|
| Population |
South African |
Detail Info
| Sample Diagnosis |
DSM |
| Sample Status |
The cohort comprised of two groups: a group of BD Type 1 affected individuals (cases) and the background population group (controls). Blood samples were previously obtained, with the appropriate written informed consent. This study was approved by the University of Cape Town Health Science Faculty Research Ethics Committee (081/96) and is in accordance with the guidelines of the Helsinki Declaration of 2000.The Division of Human Genetics has a BD database consisting of 883 individuals comprising 185 families. For the purposes of this study, the cases consisted of 191 individuals specifically diagnosed with BD Type 1 with the Structured Clinical Interview for the DSM-IV (SCID). This group comprised of 87 (46%) males and 104 (54%) females of ages ranging from 22 to 91 years. Subjects included 103 (54%)individuals of mixed ancestry and 88 (46%) Caucasian individuals. The cases included 95 individuals from 36 families that were related to at least one other case. The age of onset, number of depressive episodes, number of hospitalisations due to mania and depression of each of the cases were noted, as well as history of psychotic symptoms. The control group consisted of 188 unrelated individuals not diagnosed with any psychiatric disorder, and similar to the cases in terms of age, gender and ethnicity. |
| Technique |
PCR and sequencing |
| Statistical Method |
For this analysis, logistic regression was used. |
| Result Summary |
Using haplotype-based haplotype relative risk (HHRR) and transmission/disequilibrium (TDT) analyses, no evidence was found for an association of 5HT-2A with bipolar affective disorder under the assumption of no imprinting and of imprinting. |
SNPs reported by this study for BD (count: 3)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs6465084 |
GRM3
|
|
|
SNP Allele Frequencies: logistic regression, for Caucasian, , Mixed Ancestry, P-value = 0.5953; for Caucasian only, P-value = 0.3054; for Mixed Ancestry only, P-value = 0.7887
|
No significant association was observed in BP-I.
No significant association was observed in BP-I.
|
Negative
|
| rs1019385 |
GRIN2B
|
|
|
SNP Allele Frequencies: logistic regression, for Caucasian, Mixed Ancestry, P-value = 0.8268; for Caucasian only, P-value = 0.9181; for Mixed Ancestry only, P-value = 0.8304
|
No significant association was observed in BP-I.
No significant association was observed in BP-I.
|
Negative
|
| rs701567 |
DAOA
DAOA-AS1
|
|
|
SNP Allele Frequencies: logistic regression, for Caucasian, , Mixed Ancestry, P-value = 0.2; for Caucasian only, P-value = 0.8961; for Mixed Ancestry only, P-value = 0.0725
|
No significant association was observed in BP-I.
No significant association was observed in BP-I.
|
Negative
|
Genes reported by this study for BD (count: 3)
| Gene |
Statistical Values/Author Comments |
Result Category |
| GRM3 |
There were no significant difference in SNP allele frequencies between cases and controls.
There were no significant difference in SNP allele frequencies between cases and controls.
|
Negative
|
| DAOA |
There were no significant difference in SNP allele frequencies between cases and controls.
There were no significant difference in SNP allele frequencies between cases and controls.
|
Negative
|
| GRIN2B |
There were no significant difference in SNP allele frequencies between cases and controls.
There were no significant difference in SNP allele frequencies between cases and controls.
|
Negative
|
