BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Prata, D., 2008 PMID: 18165970
Citation	Prata, D., G. Breen, et al. (2008). "Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder." Am J Med Genet B Neuropsychiatr Genet 147B(6): 914-917.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	213 bipolar disorder I patients, and 197 healthy controls
SNP/Region/Marker Size	8 SNPs
Predominant Ethnicity	Caucasian
Population	Scottish

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Subjects had been receiving lithium therapy for at least 3 years.
Technique	Genotyping was performed under contract by Kbioscience using a competitive allele specific PCR system (CASP).
Statistical Method	For the genotype and allele-wise statistical analysis we used both X² and Fisher's Exact Test to analyze the individual polymorphisms. GENECOUNTING software (version 1.3) was used to estimate the haplotype frequencies from the genotype data (with 1000 permutations/simulations) and Cramer's V and Absolute D' to assess linkage disequilibrium (LD) between the SNPs within each gene. To test for interaction between the two genes, we used GAIA(Genetic Association Interaction Analysis) software as well as WHAP version 2.06.
Result Summary	Although none of the individual SNPs in these genes reached statistical significance, we found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two SNPhaplotype forG72(DAOA)/G30. However, we found no evidence for an epistatic interaction between the SNPs and/or haplotypes of the two genes.

SNPs reported by this study for BD (count: 8)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs3741775	DAO DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs3916966	DAOA-AS1 DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs3916972	DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs3918346	DAO DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs3918347	DAO			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs746187	DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs2111902	DAO DAOA			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
rs2391191	DAOA DAOA-AS1			data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative

Haplotypes reported by this study for BD (count: 8)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2111902 - rs3918346		DAO	Global X<sup>2</sup>=14.94, df=3, P-value = 0.003.	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs2111902 - rs3918346 - rs3741775		DAO	Global X<sup>2</sup>=16.76, df=7, P-value = 0.01.	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs2111902 - rs3918346	2-2: A-T	DAO	Z-score=3.07, P-value = 0.002	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs746187 - rs3916972	1-1: G-G	DAOA	Z-score=2.81, P-value = 0.005	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs2111902 - rs3918346 - rs3916972		DAO	Global X<sup>2</sup>=15.22, df=6, P-value = 0.02.	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs2111902 - rs3918346 - rs3741775	2-2-1: A-T-T	DAO	Z-score=3.05, P-value = 0.002	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs746187 - rs3916972		DAOA	Global X<sup>2</sup>=6.64, df=3, P-value = 0.05.	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive
rs2111902 - rs3918346 - rs3916972	2-2-1: A-T-A	DAO	Z-score=3.08, P-value = 0.002	We found haplotype wise associations with bipolar disorder f...... We found haplotype wise associations with bipolar disorder for both genes. These included a two-SNP haplotype in DAO and a two- SNPhaplotype forDAOA. More...	Positive

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
DAOA	Analysis of each SNP individually showed no significant association. Analysis of each SNP individually showed no significant association.	Negative
DAO	Analysis of each SNP individually showed no significant association. Analysis of each SNP individually showed no significant association.	Negative