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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Hattori, E.,2003 PMID: 12647258 |
|---|---|
| Citation | Hattori, E., C. Liu, et al. (2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series." Am J Hum Genet 72(5): 1131-1140. |
| Disease Type | Bipolar Disorder |
| Study Design | family-based |
| Study Type | Candidate-gene association study |
| Sample Size | the Clinical Neurogenetics (CNG) pedigrees with 83 samples from 22 multiplex families, and the National Institute of Mental Health (NIMH) Genetics Initiative pedigrees, with 474 samples from 152 families. |
| SNP/Region/Marker Size | 16 SNPs |
| Predominant Ethnicity | |
| Population | CNG and NIMH data sets |
Detail Info
| Statistical Method | the Transmission Disequilibrium Test (TDT) |
|---|---|
| Result Summary | We performed transmission/disequilibrium testing (TDT) and haplotype analysis, since a linkage-disequilibrium block was present at this gene locus. In the CNG and NIMH data sets, the results of global TDT of the entire haplotype set were significant and consistent (P=.0004 and P=.008, respectively). In the CNG series, the associated genotypes divided the families into those with linkage and those without linkage (partitioned by the linkage evidence). Analysis of the decay of haplotype sharing gave a location estimate that included G72/G30 in its 95% confidence interval. Although statistically significant association was not detected for individual SNPs in the NIMH data set, the same haplotype was consistently overtransmitted in both series. These data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes. Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs1359387 | DAOA | A/G | A | Association analysis: for CNG pedigrees, TDT P-value = 0.53, Transmission Ratio=0.65 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs1998654 | DAOA | C/T | T | Association analysis: for CNG pedigrees, TDT P-value = 1, Transmission Ratio=0.38 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs1815686 | DAOA-AS1 DAOA | C/G | C | Association analysis: for CNG pedigrees, TDT P-value = 0.041, Transmission Ratio=0.93 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs2012887 | DAOA | C/T | C | Association analysis: for CNG pedigrees, TDT P-value = 0.17, Transmission Ratio=0.58 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs1935058 | DAOA-AS1 DAOA | C/T | C | Association analysis: for CNG pedigrees, TDT P-value = 0.00077, Transmission Ratio=1; for NIMH pedigrees, TDT P-value = 0.055, Transmission Ratio=0.63 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1341402 | DAOA DAOA-AS1 | C/T | T | Association analysis: for CNG pedigrees, TDT P-value = 0.0075, Transmission Ratio=0.8; for NIMH pedigrees, TDT P-value = 0.58, Transmission Ratio=0.56 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935062 | DAOA DAOA-AS1 | A/C | A | Association analysis: for CNG pedigrees, TDT P-value = 0.0078, Transmission Ratio=0.11; for NIMH pedigrees, TDT P-value = 0.38, Transmission Ratio=0.43 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs778294 | DAOA DAOA-AS1 | A/G | G | Association analysis: for CNG pedigrees, TDT P-value = 0.018, Transmission Ratio=0.83; for NIMH pedigrees, TDT P-value = 0.24, Transmission Ratio=0.61 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs778334 | DAOA-AS1 DAOA | T/C | T | Association analysis: for CNG pedigrees, TDT P-value = 0.8, Transmission Ratio=0.5 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs2181953 | DAOA | A/T | T | Association analysis: for CNG pedigrees, TDT P-value = 0.39, Transmission Ratio=0.47 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs2391191 | DAOA DAOA-AS1 | A/G | A | Association analysis: for CNG pedigrees, TDT P-value = 0.08, Transmission Ratio=0.84; for NIMH pedigrees, TDT P-value = 0.39, Transmission Ratio=0.57 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs978714 | DAOA | A/G | G | Association analysis: for CNG pedigrees, TDT P-value = 0.62, Transmission Ratio=0.67 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs947267 | DAOA DAOA-AS1 | A/C | A | Association analysis: for CNG pedigrees, TDT P-value = 0.17, Transmission Ratio=0.7; for NIMH pedigrees, TDT P-value = 0.58, Transmission Ratio=0.48 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| rs954581 | DAOA-AS1 DAOA | C/T | T | Association analysis: for CNG pedigrees, TDT P-value = 0.62, Transmission Ratio=0.57; for NIMH pedigrees, TDT P-value = 0.11, Transmission Ratio=0.65 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
| Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | T-T-G-A-A-G-C | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For CNG pedigrees, P-value = 0.7, Transmission Ratio=0.4, For NIMH pedigrees, P-value = 0.06, Transmission Ratio=0.32 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | T-T-G-A-A-G-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For CNG pedigrees, P-value = 0.1, Transmission Ratio=0.17 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | T-T-G-A-C-A-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For NIMH pedigrees, P-value = 0.04, Transmission Ratio=0.29 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | T-T-G-A-C-G-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), , For NIMH pedigrees, P-value = 0.1, Transmission Ratio=0.62 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | C-T-G-A-C-G-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For CNG pedigrees, P-value = 0.1, Transmission Ratio=0.83 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | C-T-A-C-A-G-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For CNG pedigrees, P-value = 0.0003, Transmission Ratio=0.94, For NIMH pedigrees, P-value = 0.06, Transmission Ratio=0.6 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | C-T-A-A-A-G-C | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For NIMH pedigrees, P-value = 0.8, Transmission Ratio=0.43 | Significant association was found in BD. Significant association was found in BD. | Positive |
| rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581 | C-C-G-A-C-A-T | DAOA | TDT by Haplotype:global P-value = 0.0004(CNG), global P-value = 0.008(NIMH), For CNG pedigrees, P-value = 0.008, Transmission Ratio=0.18, For NIMH pedigrees, P-value = 0.3, Transmission Ratio=0.44 | Significant association was found in BD. Significant association was found in BD. | Positive |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| DAOA | These data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G...... These data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes. More... | Positive |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016