Region Report

Basic Info

Region Name	Chr 4
Chromosome Position	chr4:0-190214555
No. of Studies (Positive/Negative/Trend)	3(0/3/0)

Region related studies (count: 3)

Reference	Markers	Statistical Values	Author Comments	Result Category
Avramopoulos, D., 2007	D4S3013 (BPI, BPII), D4S2620 (BPI, restricted)	P-value = 0.02, NPL = 2.06, Dominant Max HLOD = 0.86, Rec...... P-value = 0.02, NPL = 2.06, Dominant Max HLOD = 0.86, Recessive Max HLOD = 1.07 in Ashkenazi pedigrees; P-value = 0.033, NPL = 1.86, Dominant Max HLOD = 0.341, Recessive Max HLOD = 0.375 in BPI-restricted pedigrees More...	the absolute value of the resulting scores remained moderate the absolute value of the resulting scores remained moderate	Negative
Murphy, V. E.,2000	D4S1558	Linkage analysis: broad model, NPL = 0.597, P-value = 0.26; ...... Linkage analysis: broad model, NPL = 0.597, P-value = 0.26; narrow model, NPL = 0.469, P-value = 0.18 More...	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Badner, J. A.,2002		Meta analysis: Location: 16, Single Analysis MSP = 0.007, Be...... Meta analysis: Location: 16, Single Analysis MSP = 0.007, Best Analysis MSP = 0.006 More...	No significant linkage was found in this region. No significant linkage was found in this region.	Negative

Region related genes (count: 51)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ANK2	ankyrin 2, neuronal	4q25-q26	1(0/1/0)
QDPR	quinoid dihydropteridine reductase	4p15.31	1(1/0/0)
SORCS2	sortilin-related VPS10 domain containing receptor 2	4p16.1	5(3/2/0)
NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	4q26	1(1/0/0)
WFS1	Wolfram syndrome 1 (wolframin)	4p16.1	7(1/6/0)
RNF212	ring finger protein 212	4p16.3	1(0/0/1)
RNF4	ring finger protein 4	4p16.3	1(0/0/1)
LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	4q12	1(1/0/0)
USP46	ubiquitin specific peptidase 46	4q12	1(0/1/0)
CFAP97	cilia and flagella associated protein 97	4q35.1	1(0/1/0)
TACC3	transforming, acidic coiled-coil containing protein 3	4p16.3	1(1/0/0)
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	4p12	3(2/0/1)
PI4K2B	phosphatidylinositol 4-kinase type 2 beta	4p15.31	1(0/1/0)
KIAA1430	cilia and flagella associated protein 97	4q35.1	0
EPHA5	EPH receptor A5	4q13.1	1(1/0/0)
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	4p16.1	1(0/0/1)
KIAA1239	NACHT and WD repeat domain containing 2	4p14	0
PDLIM5	PDZ and LIM domain 5	4q22	5(4/1/0)
IGFBP7	insulin-like growth factor binding protein 7	4q12	2(1/1/0)
TRIML2	tripartite motif family-like 2	4q35.2	1(0/1/0)
DGKQ	diacylglycerol kinase, theta 110kDa	4p16.3	1(0/0/1)
ADRA2C	adrenoceptor alpha 2C	4p16.3	1(0/1/0)
FSTL5	follistatin-like 5	4q32.3	1(0/0/1)
DRD5	dopamine receptor D5	4p16.1	2(0/2/0)
EVC	Ellis van Creveld syndrome	4p16	1(0/0/1)
NPFFR2	neuropeptide FF receptor 2	4q21	1(0/1/0)
FGFRL1	fibroblast growth factor receptor-like 1	4p16	1(0/0/1)
MAPK10	mitogen-activated protein kinase 10	4q22-q23	1(0/1/0)
CLOCK	clock circadian regulator	4q12	12(5/7/0)
AFF1	AF4/FMR2 family, member 1	4q21.3	1(0/1/0)
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	4p12	2(2/0/0)
HGFAC	HGF activator	4p16	1(0/0/1)
MARCH1	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	4q32.2	1(0/1/0)
PALLD	palladin, cytoskeletal associated protein	4q32.3	1(1/0/0)
KCNIP4	Kv channel interacting protein 4	4p15.32	1(0/1/0)
WDR1	WD repeat domain 1	4p16.1	1(0/0/1)
HTT	huntingtin	4p16.3	1(0/0/1)
CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	4p14	2(0/2/0)
FAM149A	family with sequence similarity 149, member A	4q35.1	1(0/1/0)
MTNR1A	melatonin receptor 1A	4q35	1(0/1/0)
NR3C2	nuclear receptor subfamily 3, group C, member 2	4q31	1(1/0/0)
DHX15	DEAH (Asp-Glu-Ala-His) box helicase 15	4p15.3	1(1/0/0)
LRP2BP	LRP2 binding protein	4q35.1	1(0/1/0)
POLN	polymerase (DNA directed) nu	4p16.3	1(0/0/1)
LGI2	leucine-rich repeat LGI family, member 2	4p15.31	1(1/0/0)
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	4q13	1(0/0/1)
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	4p16.1	2(1/1/0)
IRF2	interferon regulatory factor 2	4q34.1-q35.1	1(1/0/0)
NWD2	NACHT and WD repeat domain containing 2	4p14	1(0/0/1)
GPR78	G protein-coupled receptor 78	4p16.1	2(2/0/0)
ZNF732	zinc finger protein 732	4p16.3	1(0/0/1)

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Region: chr4:0..190214555 View in gBrowse