Meta-analysis Report

Reference	Badner, J. A.,2002 PMID: 11986984
Citation	Badner, J. A. and E. S. Gershon (2002). "Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia." Mol Psychiatry 7(4): 405-411.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Genome-wide linkage study

Samples	For bipolar disorder: 11 studies containing 353 families with 1228 affecteds;for schizophrenia:18 studies containing 681 families with 1929 affecteds
Statistic Method	Badner and Gershon (2001) presented a technique of meta-analysis of linkage data that could be applied to published genome scans. It combines the reported P-values of individual studies, after correcting each value for the size of the region containing a minimum P-value. Simulations demonstrated that the type I error rate was at least as low as that for a single genome scan and thus genome-wide significance criteria may be applied. Power to detect linkage was at least as high as the power of pooling the data from all the studies. It was used in this study.
Basic Result	We found the strongest evidence for susceptibility loci on 13q (P < 6 x 10(-6)) and 22q (P < 1 x 10(-5)) for bipolar disorder, and on 8p (P < 2 x 10(-4)), 13q (P < 7 x 10(-5)), and 22q (P < 9 x 10(-5)) for schizophrenia.