Gene Report

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Basic Info

Approved Symbol	TRIML2
Symbol Alias	FLJ25801, SPRYD6
Approved Name	tripartite motif family-like 2
Name Alias	SPRY domain containing 6
Location	4q35.2
Position	chr4:188091273-188109603, -1
External Links	HGNC: 26378 Entrez Gene: 205860 Ensembl: ENSG00000179046 UCSC: uc003izl.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Blair, I. P.,2005	SNP: rs13139393, rs17881718, rs17883789, rs17884102, rs2279550, rs4862860	Our data suggest that this candidate gene analyzed can be excluded from involvement in the disorder.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016874	ligase activity	molecular function	IEA	16
GO:0016567	protein ubiquitination	biological process	IEA	18
GO:0032526	response to retinoic acid	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 11)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs13139393	chr4:188105370 - 188105370(1)	5_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs17883789	chr4:188097332 - 188097332(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; synonymous_variant	1(0/1/0)
rs4862860	chr4:188101266 - 188101266(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs17881718	chr4:188091526 - 188091526(1)	3_prime_UTR_variant; NMD_transcript_variant; synonymous_variant	1(0/1/0)
rs17884102	chr4:188105419 - 188105419(1)	5_prime_UTR_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2279550	chr4:188091574 - 188091574(1)	3_prime_UTR_variant; NMD_transcript_variant; synonymous_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs902909	chr4:188100311 - 188100311(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4862858	chr4:188095961 - 188095961(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs4862857	chr4:188095904 - 188095904(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs13123649	chr4:188108911 - 188108911(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12647135	chr4:188090020 - 188090020(1)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q35	chr4:182300000-190214555	4 (0/1/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:188091273..188109603 View in gBrowse