Gene Report

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Basic Info

Approved Symbol	LRP2BP
Symbol Alias	DKFZp761O0113
Approved Name	LRP2 binding protein
Location	4q35.1
Position	chr4:185363879-185395899, -1
External Links	HGNC: 25434 Entrez Gene: 55805 Ensembl: ENSG00000109771 UCSC: uc003ixj.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Blair, I. P.,2005	SNP: rs17884285, rs3797026	Our data suggest that this candidate gene analyzed can be excluded from involvement in the disorder.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005515	protein binding	molecular function	IPI[12508107]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LRP2BP	TSC22D4	NO	yeast 2-hybrid	12508107
LRP2BP	SNW1	NO	yeast 2-hybrid	12508107
LRP2BP	COPS3	NO	yeast 2-hybrid	12508107
LRP2BP	RBM4	NO	yeast 2-hybrid	12508107
LRP2BP	BAI2	NO	yeast 2-hybrid	12508107
LRP2BP	LRP2	NO	in vitro;yeast 2-hybrid	12508107

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3797026	chr4:185373044 - 185373044(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; synonymous_variant	1(0/1/0)
rs17884285	chr4:185374021 - 185374021(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs1048329		chr4:185378604 - 185378604(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant
rs1288548		chr4:185378831 - 185378831(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q35	chr4:182300000-190214555	4 (0/1/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:185363879..185395899 View in gBrowse