Gene Report

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Basic Info

Approved Symbol	QDPR
Symbol Alias	DHPR, PKU2, SDR33C1
Approved Name	quinoid dihydropteridine reductase
Name Alias	6,7-dihydropteridine reductase, "short chain dehydrogenase/reductase family 33C, member 1"
Location	4p15.31
Position	chr4:17460261-17512234, -1
External Links	HGNC: 9752 Entrez Gene: 5860 Ensembl: ENSG00000151552 UCSC: uc003gpd.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shi, J., 2008 (b)	SNP: rs744731 Haplotype: rs2597758 - rs1031326 - rs744731 - rs2597778(AGGA)	rs744731 in the QDPR reached gene-wide association (permutation P<0.05 for all SNPs of each gene). . None of these associations survived multiple testing for its own system (e.g., glutamatergic or serotoninergic) or all the five systems taken together (permutation adjusted P>0.05)ã€‚	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0043005	neuron projection	cellular component	IEA	38
GO:0005829	cytosol	cellular component	TAS	223
GO:0006520	cellular amino acid metabolic process	biological process	TAS[3033643]	5
GO:0006729	tetrahydrobiopterin biosynthetic process	biological process	IEA	3
GO:0070402	NADPH binding	molecular function	IEA	3
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0010044	response to aluminum ion	biological process	IEA	2
GO:0035690	cellular response to drug	biological process	IEA	13
GO:0004155	6,7-dihydropteridine reductase activity	molecular function	EXP	1
GO:0033762	response to glucagon	biological process	IEA	3
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0006559	L-phenylalanine catabolic process	biological process	TAS	2
GO:0001889	liver development	biological process	IEA	14
GO:0070404	NADH binding	molecular function	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0051066	dihydrobiopterin metabolic process	biological process	TAS[3033643]	1
GO:0009055	electron carrier activity	molecular function	TAS[3033643]	5
GO:0010288	response to lead ion	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00790	Folate biosynthesis	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs744731	chr4:17491220 - 17491220(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs3796809		chr4:17502216 - 17502216(1)	intron_variant; NMD_transcript_variant
rs10516314		chr4:17498190 - 17498190(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p14-p15	chr4:11300000-41200000	1 (0/1/0)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:17460261..17512234 View in gBrowse