Study Report
Basic Info
| Reference |
Geller, B.,2004 PMID: 15337662
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| Citation |
Geller, B., J. A. Badner, et al. (2004). "Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype." Am J Psychiatry 161(9): 1698-1700.
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| Disease Type |
Bipolar Disorder |
| Study Design |
family-based |
| Study Type |
Candidate-gene association study |
| Sample Size |
53 complete, independent trios |
| SNP/Region/Marker Size |
1 variant |
| Predominant Ethnicity |
|
| Population |
American |
| Gender |
35.8% females |
| Age Group |
Adolescent
:
Mean age(SD)(year):10.7(2.7),7.6(3.6) at onset
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Detail Info
| Sample Diagnosis |
DSM |
| Sample Status |
Probands were a subset of subjects in the NIMH-funded Phenomenology and Longitudinal Course of Pediatric Bipolar Disorders study and were obtained by consecutive new case ascertainment from designated pediatric and child psychiatry venues, using methods described in detail elsewhere |
| Technique |
genotyping |
| Statistical Method |
Genotype data were analyzed with the Family Based Association Test program (http://www.biostat.harvard.edu/~fbat/fbat.htm) and with the ASPEX/sib_tdt program. |
| Result Summary |
RESULTS: There were 53 complete, independent trios. The BDNF Val66 allele was preferentially transmitted (Family Based Association Test: chi(2)=6.0, df=1, p=0.014). CONCLUSIONS: This finding in child bipolar disorder is consistent with data for adults with bipolar disorder that show preferential transmission of the Val66 allele. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| BDNF Val66Met |
BDNF |
point mutation |
Val66Met |
|
Association analysis:FBAT, chi square=6.0, 1df, P-value = 0.14
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Significant association was found in BPD patients.
Significant association was found in BPD patients.
|
Positive
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| BDNF |
This finding in child bipolar disorder is consistent with data for adults with bipolar disorder that......
This finding in child bipolar disorder is consistent with data for adults with bipolar disorder that show preferential transmission of the Val66 allele.
More...
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Positive
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