BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Liu, L., 2008 PMID: 19018231
Citation	Liu, L., T. Foroud, et al. (2008). "Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder." Psychiatr Genet 18(6): 267-274.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	A whole genome screen was completed in 644 families consisting of 2,909 individuals. A total of 250 multiplex families, consisting of 1,749 individuals were selected for genotyping
SNP/Region/Marker Size	10 SNPs
Predominant Ethnicity	Caucasian
Population	American
Gender	771 males and 978 females, were selected for genotyping
Age Group	adults : All affected subjects were at least 16 years of age.

Detail Info

SNPs reported by this study for BD (count: 10)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6265	BDNF BDNF-AS			Average PDT statistic P-value = 0.4 for the model 1; average PDT statistic P-value = 0.26 for the model 2; average PDT statistic P-value = 0.06 for the model 3 between the SNP and bipolar disorder.	The previously reported Val66Met polymorphism (rs6265) was n...... The previously reported Val66Met polymorphism (rs6265) was not significantly associated with either bipolar disorder or rapid cycling More...	Negative
rs7103411	BDNF BDNF-AS			Average PDT statistic P-value = 0.64 for the model 1; average PDT statistic P-value = 0.69 for the model 2; average PDT statistic P-value = 0.27 for the model 3 between the SNP and bipolar disorder.	This SNP did not provide evidence of association using any o...... This SNP did not provide evidence of association using any of the three disease models. More...	Negative
rs2030324	BDNF			Average PDT statistic P-value = 0.02 for the model 1; average PDT statistic P-value = 0.04 for the model 2; average PDT statistic P-value = 0.16 for the model 3 between the SNP and bipolar disorder.	this SNP provided evidence of association when the two narro...... this SNP provided evidence of association when the two narrower models of disease were employed More...	Positive
rs2883187	BDNF			Average PDT statistic P-value = 0.02 for the model 1; average PDT statistic P-value = 0.04 for the model 2; average PDT statistic P-value = 0.14 for the model 3 between the SNP and bipolar disorder.	this SNP provided evidence of association when the two narro...... this SNP provided evidence of association when the two narrower models of disease were employed More...	Positive
rs988748	BDNF			Average PDT statistic P-value = 0.55 for the model 1; average PDT statistic P-value = 0.58 for the model 2; average PDT statistic P-value = 0.21 for the model 3 between the SNP and bipolar disorder.		Negative
rs7127507	BDNF BDNF-AS			Average PDT statistic P-value = 0.002 for the model 1; average PDT statistic P-value = 0.009 for the model 2; average PDT statistic P-value = 0.009 for the model 3 between the SNP and bipolar disorder.	Initial PDT analyses employing a liberal definition of unaff...... Initial PDT analyses employing a liberal definition of unaffected detected some evidence of association (p<0.03) with two SNPs (rs1519480 and rs7127507) in BDNF across all three hierarchical bipolar disorder models. More...	Positive
rs7934165	BDNF			Average PDT statistic P-value = 0.12 for the model 1; average PDT statistic P-value = 0.24 for the model 2; average PDT statistic P-value = 0.58 for the model 3 between the SNP and bipolar disorder.		Negative
rs1519480	BDNF BDNF-AS			Average PDT statistic P-value = 0.005 for the model 1; average PDT statistic P-value = 0.02 for the model 2; average PDT statistic P-value = 0.03 for the model 3 between the SNP and bipolar disorder.	Initial PDT analyses employing a liberal definition of unaff...... Initial PDT analyses employing a liberal definition of unaffected detected some evidence of association (p<0.03) with two SNPs (rs1519480 and rs7127507) in BDNF across all three hierarchical bipolar disorder models. More...	Positive
rs12273363	BDNF			Average PDT statistic P-value = 0.05 for the model 1; average PDT statistic P-value = 0.12 for the model 2; average PDT statistic P-value = 0.1 for the model 3 between the SNP and bipolar disorder.	this SNP provided evidence only for the narrowest model. this SNP provided evidence only for the narrowest model.	Positive
rs11030104	BDNF BDNF-AS			Average PDT statistic P-value = 0.78 for the model 1; average PDT statistic P-value = 0.87 for the model 2; average PDT statistic P-value = 0.35 for the model 3 between the SNP and bipolar disorder.	This SNP did not provide evidence of association using any o...... This SNP did not provide evidence of association using any of the three disease models. More...	Negative

Genes reported by this study for BD (count: 1)