BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Tang, J., 2008 PMID: 18242852
Citation	Tang, J., L. Xiao, et al. (2008). "Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China." Neurosci Lett 433(2): 98-102.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	197 BD and 208 controls
SNP/Region/Marker Size	2 SNPs
Predominant Ethnicity	Mongloid
Population	Han Chinese
Gender	BD patients (107 females and 90 males); healthy controls (97 females and 111 males)
Age Group	BD patients: mean age=26.4 (SD=10.8) years; healthy controls: mean age=34.7 (SD=8.3) years,

Detail Info

Sample Diagnosis	DSM-IV
Technique	PCR and genotyping
Statistical Method	Overall allele and genotype distributions for each SNPs in BPD patients and controls were compared using the GENEPOP program to test Hardy-Weinberg equilibrium. The statistical significance of differences in the genotype distribution and allele frequency between patients and controls was assessed by a chi-square test or Fisher's exact test at a significance level of 0.05, two-tailed. Linkage disequilibrium was calculated using the SHEsis program.
Result Summary	No significantly statistical differences of these two polymorphisms were found in genotypes or allele frequencies between either overall patients or late age of onset patients and normal control subjects. However, the frequency of the Val allele of the Val66Met polymorphism was found to have significantly increased in the subgroup patients with early age of onset as compared with the controls (genotype: X² = 6.602, df = 2, P = 0.037; allele: X² = 6.223, df = 1, P = 0.015). The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole. But Val66Met may be associated with susceptibility to the early age of onset subset of the disorder.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
BDNF Val66Met	BDNF	point mutation	C/T		Genotypic X²=1.538 (df=2), P-value = 0.463; Allelic X²=1.277 (df=1), P-value = 0.285	No significant difference was found in the frequency of the ...... No significant difference was found in the frequency of the genotype or allele in this polymorphism between patients and controls. More...	Negative
BDNF C270T	BDNF	point mutation	C/T		Genotypic X²=0.333 (df=1), P-value = 0.586; Allelic X²=0.319 (df=1), P-value = 0.594	No significant difference was found in the frequency of the ...... No significant difference was found in the frequency of the genotype or allele in this polymorphism between patients and controls. More...	Negative

Genes reported by this study for BD (count: 1)