Study Report
Basic Info
| Reference |
Neves, F. S.,2011 PMID: 21167606
|
| Citation |
Neves, F. S., L. Malloy-Diniz, et al. (2011). "The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities." J Affect Disord 131(1-3): 307-311.
|
| Disease Type |
Bipolar I Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
160 BD patients and 160 healthy controls |
| SNP/Region/Marker Size |
4 SNPs |
| Predominant Ethnicity |
Caucasian |
| Population |
Brazilian |
Detail Info
| Sample Diagnosis |
DSM |
| Technique |
genotyping |
| Statistical Method |
Comparisons between categorical variables were compared using chi-square or fisher's test. Continuous variables were compared using Student's t-test. |
| Result Summary |
RESULTS: No genotypic, allelic or haplotype differences were found between bipolar patients and healthy controls. Concerning exclusively the rs4923463 (G/G) there was a significant association with alcoholism (p=0.009), smoking (p=0.006) and violent suicide attempt (p=0.03). We further found that the G-G haplotype (rs4923463-rs2049045) (adjusted p=0.029) and the G-T haplotype (rs4923463-rs7103411) (adjusted p=0.029) were significantly more frequent in the group with alcoholism co-morbidity when compared with the group without this co-morbidity. LIMITATIONS: Sample size and retrospective assessment of suicide behavior and psychiatric comorbidities. CONCLUSIONS: The results obtained in our study indicate that BDNF variants may confer susceptibility to additional psychiatric diagnosis in BD. |
SNPs reported by this study for BD (count: 4)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs2049045 |
BDNF
BDNF-AS
|
G/C |
|
chi-square test: allele, P-value = 0.654, OR(95%CI)=0.89(0.56-1.43), genotype, P-value = 0.479
|
No significant association was observed.
No significant association was observed.
|
Negative
|
| rs7103411 |
BDNF
BDNF-AS
|
T/C |
|
chi-square test: allele, P-value = 0.969, OR(95%CI)=1.08(0.66-1.53), genotype, P-value = 0.998
|
No significant association was observed.
No significant association was observed.
|
Negative
|
| rs4923463 |
BDNF
BDNF-AS
|
G/A |
|
chi-square test: allele, P-value = 0.52, OR(95%CI)=1.14(0.75-1.74), genotype, P-value = 0.691
|
No significant association was observed.
No significant association was observed.
|
Negative
|
| rs6265 |
BDNF
BDNF-AS
|
T/C |
|
chi-square test: allele, P-value = 0.474, OR(95%CI)=0.83(0.50-1.37), genotype, P-value = 0.123
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| BDNF |
No genotypic, allelic or haplotype differences were found between bipolar patients and healthy contr......
No genotypic, allelic or haplotype differences were found between bipolar patients and healthy controls.
More...
|
Negative
|
