SNP Report

Basic Info

Name	rs12273363 dbSNP Ensembl
Location	chr11:27723312 - 27723312(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.0974441
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000530663); non_coding_transcript_variant(ENST00000530663); upstream_gene_variant(ENST00000314915, ENST00000395978, ENST00000395981, ENST00000525950, ENST00000532997)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Risk Allele	Statistical Values	Author Comments	Result Category
Ivanova, M. A.,2012		Caseâ€“control study:all P-value > 0.05 Caseâ€“control study:all P-value > 0.05	No significant association was observed. No significant association was observed.	Negative
Sears, C.,2011	T	FBAT: MAF=0.184, P-value = 0.008 FBAT: MAF=0.184, P-value = 0.008	Significant association was found . Significant association was found .	Positive
Liu, L., 2008		Average PDT statistic P-value = 0.05 for the model 1; avera...... Average PDT statistic P-value = 0.05 for the model 1; average PDT statistic P-value = 0.12 for the model 2; average PDT statistic P-value = 0.1 for the model 3 between the SNP and bipolar disorder. More...	this SNP provided evidence only for the narrowest model. this SNP provided evidence only for the narrowest model.	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
BDNF	brain-derived neurotrophic factor	11p14.1	37(24/12/1)

SNPs in LD with rs12273363 (count: 3) View in gBrowse (chr11:27679818..27726946 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs10835211	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.855[TSI]
rs17309930	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs12288512	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.959[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)