BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Kunugi, H.,2004 PMID: 15336520
Citation	Kunugi, H., Y. Iijima, et al. (2004). "No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study." Biol Psychiatry 56(5): 376-378.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	519 patients with bipolar disorder and 588 control subjects
SNP/Region/Marker Size	1 variant
Predominant Ethnicity	Mongloid
Population	Japanese
Gender	Male/female:244/265 for bipolar disorder cases,287/201 for normal controls
Age Group	Adults : Mean age (SD) for the patients was 49.3(14.3) years and for the control subjects was 48.4(12.7) years.

Detail Info

Sample Diagnosis	DSM
Sample Status	Six laboratories (National Institute of Mental Health, two laboratories of the Brain Science Institute, Showa University, Tokyo Women's Medical College, and Fujita Health University) collected deoxyribonucleic acid (DNA) samples from patients with bipolar disorder and healthy control subjects. Each institute provided DNA samples of patients and control subjects matched for gender, age, and geographic area, which yielded a combined sample of 519 patients with bipolar disorder and 588 control subjects.All the patients and control subjects were Japanese and biologically unrelated. Consensus diagnosis of bipolar disorder was made for each patient by at least two experienced psychiatrists according to DSM-IV criteria (American Psychiatric Association 1994) on the basis of unstructured interviews and medical records. Among the patients, 347 were diagnosed as bipolar I and the remaining 172 as bipolar II. Control subjects were healthy volunteers who had no current or past contact with psychiatric services. The control subjects were recruited from the hospital staffs and their associates at each institution who showed good social functioning and reported themselves to be in good health.
Technique	PCR and RFLP
Statistical Method	chi-square tests
Result Summary	RESULTS: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. CONCLUSIONS: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
BDNF Val66Met	BDNF	point mutation	Val66Met		Association analysis:chi square test, Genotypewise comparisons: total patients vs. control subjects:chi square=0, P-value = 0.98; bipolar I vs. control subjects: chi square=0.3, P-value = 0.86; bipolar II vs. control subjects: chi square=0.8, P-value = 0.69. Allelewise comparisons: total patients vs. control subjects: chi square=0.0, P-value = 0.83; bipolar I vs. control subjects: chi square=0.0, P-value = 0.96; bipolar II vs. control subjects:chi square=0.0, P-value = 0.94.	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)