BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Matsuo, K.,2009 PMID: 19295510
Citation	Matsuo, K., C. Walss-Bass, et al. (2009). Neuronal correlates of brain-derived neurotrophic factor Val66Met polymorphism and morphometric abnormalities in bipolar disorder. Neuropsychopharmacology 34(8): 1904-1913.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	42 BD patients(24 with Val/Val genotype,18 with Val/Met genotype) and 42 healthy subjects(29 with Val/Val genotype,13 with Val/Met genotype)
SNP/Region/Marker Size	1 variant
Predominant Ethnicity
Population	American
Gender	Female proportion:79.1% of BD patients with Val/Val genotype,77.8% of BD patients with Val/Met genotype,65.5% of healthy subjects with Val/Val genotype,61.5% of healthy subjects with Val/Met genotype.
Age Group	Adults : Mean age(SD)(year):36.1(9.3) of BD patients with Val/Val genotype, 35.2(9.7) of BD patients with Val/Met genotype, 35.4(10.5)of healthy subjects with Val/Val genotype,34.2 (10.4) of healthy subjects with Val/Met genotype.

Detail Info

Sample Diagnosis	DSM
Sample Status	Forty-two patients with BD and 42 healthy subjects were studied. This study was approved by the Institutional Review Board of The University of Texas Health Science Center at San Antonio. Written informed consent was obtained from all the participants after a complete description of the study was provided. The participants were recruited at hospitals and clinics and through advertisement broadcast in the community. All of the patients met DSM-IV-TR criteria for BD by the Structured Clinical Interview (SCID) for DSM-IV (First et al, 1996b).Healthy subjects were screened for DSM-IV axis I disorders by the SCID non-patient version (First et al, 1996a). Patients who had a history of electroconvulsive therapy or a substance use disorder within 6 months preceding the study were excluded. Healthy control subjects who had current or past axis I DSM-IV psychiatric disorders or had first-degree relatives with any Axis I psychiatric disorder were excluded. All participants were evaluated for handedness by the Edinburgh inventory (Oldfield, 1971). All participants also received laboratory tests and a physical examination to rule out physical illnesses. Any participant with current endocrinological disease, history of head trauma with loss of consciousness, current or previous neurological disease, family history of hereditary neurological disorders, or a current medical condition such as active liver disease, kidney problems, or respiratory problems was excluded. A senior psychiatrist (JCS) reviewed all clinical information and medical or neurological conditions and confirmed DSM-IV diagnostic criteria. Current mood states of the patients were evaluated using the 21-item Hamilton Rating Scale for Depression (HAM-D) (Hamilton, 1960) and the Young Mania Rating Scale (YMRS) (Young et al, 1978). Verbal and non-verbal general intellectual abilities were assessed using the Wechsler Test of Adult Reading (WTAR) (Holnack, 2001) and the Test of Non-verbal Intelligence-3 (TONI-3)(Brown et al, 1997).
Technique	genotyping and Magnetic resonance imaging (MRI) scans
Statistical Method	For image analysis, we used SPM2 software that implemented a General Linear Model.Fisher's exact test was applied to compare the Val66Met genotypes with regard to the control markers.The CVLT data were analyzed using ANOVA.
Result Summary	Left and right anterior cingulate GM volumes showed a significant interaction between genotype and diagnosis such that anterior cingulate GM volumes were significantly smaller in the Val/Met BD patients compared with the Val/Val BD patients (left P=0.01, right P=0.01). Within-group comparisons revealed that the Val/Met carriers showed smaller GM volumes of the dorsolateral prefrontal cortex compared with the Val/Val subjects within the BD patient (P=0.01) and healthy groups (left P=0.03, right P=0.03). The Val/Met healthy subjects had smaller GM volumes of the left hippocampus compared with the Val/Val healthy subjects (P<0.01). There was a significant main effect of diagnosis on memory function (P=0.04), but no interaction between diagnosis and genotype was found (P=0.48). The findings support an association between the BDNF Val66Met genotype and differential gray matter content in brain structures, and suggest that the variation in this gene may play a more prominent role in brain structure differences in subjects affected with BD.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
BDNF Val66Met	BDNF	point mutation	Val66Met		Imaging Data:Val/Val and Val/Met subjects (case-control), ACC GM volumes:left ACC, x= 7, y=13, z=25, t=3.55, k=66, P=0.011; right ACC, x=12, y=25, z=23, t=3.24, k=133, P=0.013.Three-way interaction:left ACC, F1, 76=1.15, P=0.29;right ACC, F1, 76=1.16, P=0.69.The diagnosis by genotype interaction:left ACC, F1, 76=5.69, P=0.02; right ACC, F1, 76=5.03, P=0.03.CVLT Performance:for diagnosis (F1, 69=4.39, P=0.04), for genotype (F1, 69=0.82, P=0.63), for the interaction between diagnosis and genotype (F4.1, 283.3=0.86, P=0.48).	Left and right anterior cingulate GM volumes showed a signif...... Left and right anterior cingulate GM volumes showed a significant interaction between genotype and diagnosis such that anterior cingulate GM volumes were significantly smaller in the Val/Met BD patients compared with the Val/Val BD patients. Within-group comparisons revealed that the Val/Met carriers showed smaller GM volumes of the dorsolateral prefrontal cortex compared with the Val/Val subjects within the BD patient and healthy groups. The Val/Met healthy subjects had smaller GM volumes of the left hippocampus compared with the Val/Val healthy subjects. There was a significant main effect of diagnosis on memory function (P=0.04), but no interaction between diagnosis and genotype was found. More...	Positive

Genes reported by this study for BD (count: 1)