BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Sears, C.,2011 PMID: 22085476
Citation	Sears, C., D. Markie, et al. (2011). "Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene." Bipolar Disord 13(7-8): 630-637.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	139 pedigrees with 200 individual nuclear families comprised of 795 individuals
SNP/Region/Marker Size	8 SNPs
Predominant Ethnicity	Caucasian
Population	New Zealander

Detail Info

Sample Diagnosis	DSM
Sample Status	Bipolar probands and their first- and seconddegree relatives were recruited from the South Island of New Zealand as part of the South Island Bipolar Study (SIBS). The recruitment process is described in Joyce et al. Probands were interviewed using the Diagnostic Interview for Genetic Studies (DIGS), and family members of the probands were assessed using the Family Interview for Genetic Studies (FIGS). The diagnoses of probands were made using standard DSM-IV criteria.The cohort consists primarily of Caucasians with ancestry from Western Europe.
Technique	genotyping
Statistical Method	the Family Based Association Test (FBAT)
Result Summary	RESULTS: We found associations (p < 0.05) between BD and six of the eight SNPs analysed, including two SNPs not previously investigated in association studies. We were able to replicate associations previously found between BD and the Val66Met polymorphism of BDNF (rs6265) and the SNPs rs1519480 and rs12273363. We also found evidence of an association between rs11030107 and BD that was not found in a previous study. CONCLUSIONS: Our results support the hypothesis that some BDNF gene polymorphisms may be contributing factors in the pathogenesis of BD. Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.

SNPs reported by this study for BD (count: 8)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6265	BDNF BDNF-AS		A	FBAT: MAF=0.173, P-value = 0.04	Significant association was found . Significant association was found .	Positive
rs7103873	BDNF BDNF-AS			FBAT: MAF=0.468, P-value = 0.9	No significant association was observed. No significant association was observed.	Negative
rs12273363	BDNF		T	FBAT: MAF=0.184, P-value = 0.008	Significant association was found . Significant association was found .	Positive
rs1519480	BDNF BDNF-AS		C	FBAT: MAF=0.287, P-value = 0.004	Significant association was found . Significant association was found .	Positive
rs11030107	BDNF BDNF-AS		A	FBAT: MAF=0.249, P-value = 0.006	Significant association was found . Significant association was found .	Positive
rs11030119	BDNF		G	FBAT: MAF=0.28, P-value = 0.003	Significant association was found . Significant association was found .	Positive
rs10835210	BDNF BDNF-AS			FBAT: MAF=0.433, P-value = 0.6	No significant association was observed. No significant association was observed.	Negative
rs11030104	BDNF BDNF-AS		C	FBAT: MAF=0.206, P-value = 0.004	Significant association was found . Significant association was found .	Positive

Genes reported by this study for BD (count: 1)