SNP Report

Basic Info

Name	rs7127507 dbSNP Ensembl
Location	chr11:27693337 - 27693337(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.323083
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000530663); intron_variant(ENST00000314915, ENST00000356660, ENST00000395978, ENST00000395980, ENST00000395981, ENST00000395983, ENST00000395986, ENST00000418212, ENST00000420794, ENST00000438929, ENST00000499568, ENST00000500662, ENST00000502161, ENST00000525950, ENST00000530786, ENST00000530861, ENST00000532997, ENST00000533131, ENST00000533246, ENST00000584049); NMD_transcript_variant(ENST00000530786); non_coding_transcript_variant(ENST00000499568, ENST00000500662, ENST00000502161, ENST00000584049)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, L., 2008			Average PDT statistic P-value = 0.002 for the model 1; aver...... Average PDT statistic P-value = 0.002 for the model 1; average PDT statistic P-value = 0.009 for the model 2; average PDT statistic P-value = 0.009 for the model 3 between the SNP and bipolar disorder. More...	Initial PDT analyses employing a liberal definition of unaff...... Initial PDT analyses employing a liberal definition of unaffected detected some evidence of association (p<0.03) with two SNPs (rs1519480 and rs7127507) in BDNF across all three hierarchical bipolar disorder models. More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
BDNF	brain-derived neurotrophic factor	11p14.1	37(24/12/1)
BDNF-AS	BDNF antisense RNA	11p14.1	Mapped by Literature SNP

SNPs in LD with rs7127507 (count: 8) View in gBrowse (chr11:27645655..27714660 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs1013402	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.916[CEU]; 0.969[TSI]
rs1401635	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.957[CEU]
rs962369	intron_variant; non_coding_transcript_variant	0.875[CEU]; 0.969[TSI]
rs925946	intron_variant; non_coding_transcript_variant	0.916[CEU]; 0.91[TSI]
rs7124442	3_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	0.957[CEU]; 0.939[TSI]
rs10767658	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.901[CEU]
rs11030121	intron_variant; non_coding_transcript_variant	0.957[CEU]
rs11030108	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.957[CEU]; 0.969[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)