BDgene

BD & SZ & MDD shared haplotype from cross-disorder studies

Total result: 51

Markers Haplotype Related Gene(s)/Region(s) Reference Overlap with SZ Overlap with MDD
Statistical Results Description Result Category
Statistical Results Description Result Category
rs7452939 - rs6903874 - rs6937506 TAAR6 Pae, C. U., 2008
Global X<sup>...... Global X<sup>2</sup>=18.49, df=3, P-value = 0.00042 More... There were signific...... There were significant global differences in haplotype frequency between schizophrenia patients compared to controls. More... Positive
Global X<sup>...... Global X<sup>2</sup>=8.80, df=3, P-value = 0.031 More... There were signific...... There were significant global differences in haplotype frequency between BID patients compared to controls. More... Positive
rs988748 - BDNF_(GT)n - rs6265 C-166bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.134 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.162; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.765 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 C-168bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.232 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.071; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.188 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 C-170bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.944 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.929; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.165 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 C-172bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.821 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.324; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.389 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 C-174bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.0033 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.001; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.388 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 G-170bp-A BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.037 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.01; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.05 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 G-174bp-A BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.0024 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.085; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.987 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 G-174bp-G BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.067 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.909; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.82 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs988748 - BDNF_(GT)n - rs6265 G-176bp-A BDNF Schumacher, J.,2005
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.627 More... Significant associa...... Significant association was found in global P-value. More... Positive
Haplotypic associat...... Haplotypic association:in Bonn sample, for MDD, global P-value = 0.000054, Bonferroni-Corrected P-value = 0.00065, individual P-value = 0.989; in Munich Sample, for MDD, global P-value = 0.0092, Bonferroni-Corrected P-value = 0.110, individual P-value = 0.081 More... Significant associa...... Significant association was found in global P-value. More... Positive
rs1170099 - rs9566940 G-T DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.0002, permutated P-value = 0.002 for SCZ More... Significant associa...... Significant association was observed in SZ. More... Positive
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs9315885 - rs9532988 - rs1012053 T-A-A DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.0005, permutated P-value = 0.005 for SCZ More... Significant associa...... Significant association was observed in SZ. More... Positive
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs2284031 - rs909486 - rs738149 C-T-G CSF2RB Chen, P.,2011
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.014(0.85) More... Significant associa...... Significant association was observed in SZ. More... Positive
Haplotype analysis:...... Haplotype analysis:for MDD, P-value(odds ratio)=0.0004(0.8) More... Significant associa...... Significant association was observed in MDD. More... Positive
rs2284031 - rs909486 - rs738149 T-C-A CSF2RB Chen, P.,2011
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.006(1.37) More... Significant associa...... Significant association was observed in SZ. More... Positive
Haplotype analysis:...... Haplotype analysis:for MDD, P-value(odds ratio)=0.001(1.44) More... Significant associa...... Significant association was observed in MDD. More... Positive
(GPR50_502-505) - rs13440581 GPR50 Thomson, P. A.,2005(b)
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.18(all), 0.3(female) More... No association was ...... No association was observed. More... Negative
Haplotypic associat...... Haplotypic association:, for MDD, P-value = 0.1(all), 0.67(female) More... No association was ...... No association was observed. More... Negative
rs2072621 - (GPR50_502-505) GPR50 Thomson, P. A.,2005(b)
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.16(all), 0.3(female) More... No association was ...... No association was observed. More... Negative
Haplotypic associat...... Haplotypic association:, for MDD, P-value = 0.055(all), 0.36(female) More... No association was ...... No association was observed. More... Negative
rs2072621 - (GPR50_502-505) - rs13440581 GPR50 Thomson, P. A.,2005(b)
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.078(all), 0.068(female) More... No association was ...... No association was observed. More... Negative
Haplotypic associat...... Haplotypic association:, for MDD, P-value = 0.14(all), 0.6(female) More... No association was ...... No association was observed. More... Negative
rs2072621 - rs13440581 GPR50 Thomson, P. A.,2005(b)
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.63(all), 0.76(female) More... No association was ...... No association was observed. More... Negative
Haplotypic associat...... Haplotypic association:, for MDD, P-value = 0.069(all), 0.27(female) More... No association was ...... No association was observed. More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 PAWR Kishi, T., 2008 (a)
Global P-value = 0....... Global P-value = 0.142 for SZ More... Negative
Global P-value = 0....... Global P-value = 0.143 for MDD More... Negative
rs960914 - rs2241802 - rs2323019 - rs352203 FZD3 Hashimoto, R.,2005(b)
Haplotypic associat...... Haplotypic association:global P-values>0.2 More... No significant ass...... No significant association was found . More... Negative
Haplotypic associat...... Haplotypic association:global P-values>0.2 More... No significant ass...... No significant association was found . More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGTA PAWR Kishi, T., 2008 (a)
P-value = 0.572 for...... P-value = 0.572 for SZ More... Negative
P-value = 0.771 for...... P-value = 0.771 for MDD More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAACG PAWR Kishi, T., 2008 (a)
P-value = 0.078 for...... P-value = 0.078 for SZ More... Negative
P-value = 0.095 for...... P-value = 0.095 for MDD More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 ATGCA PAWR Kishi, T., 2008 (a)
P-value = 0.910 for...... P-value = 0.910 for SZ More... Negative
P-value = 0.577 for...... P-value = 0.577 for MDD More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGCG PAWR Kishi, T., 2008 (a)
P-value = 0.247 for...... P-value = 0.247 for SZ More... Negative
P-value = 0.744 for...... P-value = 0.744 for MDD More... Negative
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 AAGCA PAWR Kishi, T., 2008 (a)
P-value = 0.621 for...... P-value = 0.621 for SZ More... Negative
P-value = 0.752 for...... P-value = 0.752 for MDD More... Negative
rs11939815 - rs11931061 - rs11133385 - rs3736544 - rs1801260 - rs3749474 CLOCK Kishi, T.,2009(a)
likelihood ratio te...... likelihood ratio test:haplotype(G-A-A-G-T-T):1.total samples:Global P-value = 0.340 in SCZ 2. male samples:Global P-value = 0.464 in SCZ 3. female samples:Global P-value = 0.0362, Corrected P-value = 0.0724 in SCZ More... Only one associatio...... Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). More... Negative
likelihood ratio te...... likelihood ratio test:haplotype(G-A-A-G-T-T):1.total samples:Global P-value = 0.883 in MDD 2. male samples:Global P-value = 0.461 in MDD 3. female samples:Global P-value = 0.458 in MDD More... No significant ass...... No significant association was found with MDD. More... Negative
rs1170099 - rs9566940 A-C DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.364, permutated P-value = 0.993 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs1170099 - rs9566940 A-T DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.179, permutated P-value = 0.859 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs716934 - rs9566931 - rs9315897 - rs2122246 A-A-C-G DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 1, permutated P-value = 1 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs716934 - rs9566931 - rs9315897 - rs2122246 A-A-T-G DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.623, permutated P-value = 1 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs716934 - rs9566931 - rs9315897 - rs2122246 T-A-T-A DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.243, permutated P-value = 0.945 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs716934 - rs9566931 - rs9315897 - rs2122246 T-A-T-G DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.219, permutated P-value = 0.924 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs716934 - rs9566931 - rs9315897 - rs2122246 T-G-T-G DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.297, permutated P-value = 0.976 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs9315885 - rs9532988 - rs1012053 C-A-A DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.018, permutated P-value = 0.147 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs9315885 - rs9532988 - rs1012053 C-A-C DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.116, permutated P-value = 0.719 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs9315885 - rs9532988 - rs1012053 T-G-A DGKH Zeng, Z.,2011
Haplotypic associat...... Haplotypic association:P-value = 0.446, permutated P-value = 0.998 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotypic associat...... Haplotypic association:P-value > 0.05 for MDD More... No significant asso...... No significant association was observed in MDD. More... Negative
rs11759115 - rs7769372 C-C MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.046 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.9977, individual P-value = 0.9239 More... No significant asso...... No significant association was observed. More... Negative
rs11759115 - rs7769372 T-C MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.3551 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.9977, individual P-value = 0.9999 More... No significant asso...... No significant association was observed. More... Negative
rs11759115 - rs7769372 T-T MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.9978 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.9977, individual P-value = 0.9881 More... No significant asso...... No significant association was observed. More... Negative
rs1883901 - rs10807187 - rs9462343 A-G-G MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.0732 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.8458, individual P-value = 0.5224 More... No significant asso...... No significant association was observed. More... Negative
rs1883901 - rs10807187 - rs9462343 G-G-A MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 1 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.8458, individual P-value = 0.9725 More... No significant asso...... No significant association was observed. More... Negative
rs1883901 - rs10807187 - rs9462343 G-G-G MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.4639 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.8458, individual P-value = 0.7182 More... No significant asso...... No significant association was observed. More... Negative
rs1883901 - rs10807187 - rs9462343 G-T-G MDGA1 Li, J.,2011(a)
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.9998 More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, global P-value = 0.8458, individual P-value = 0.9922 More... No significant asso...... No significant association was observed. More... Negative
rs2284031 - rs909486 - rs738149 C-T-A CSF2RB Chen, P.,2011
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.998(1) More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, P-value(odds ratio)=0.225(1.16) More... No significant asso...... No significant association was observed in MDD. More... Negative
rs2284031 - rs909486 - rs738149 T-C-G CSF2RB Chen, P.,2011
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.263(1.1) More... No significant asso...... No significant association was observed in SZ. More... Negative
Haplotype analysis:...... Haplotype analysis:for MDD, P-value(odds ratio)=0.461(1.07) More... No significant asso...... No significant association was observed in MDD. More... Negative
rs7090018 - rs11199993 T-G FGFR2 Wang, T.,2012
P-value = 0.835, Pe...... P-value = 0.835, Permutated P-value = 1.000 More... No significant asso...... No significant association was found More... Negative
P-value = 0.041, Pe...... P-value = 0.041, Permutated P-value = 0.347 More... No significant asso...... No significant association was found More... Negative
rs7090018 - rs11199993 T-C FGFR2 Wang, T.,2012
P-value = 0.112, Pe...... P-value = 0.112, Permutated P-value = 0.698 More... No significant asso...... No significant association was found More... Negative
P-value = 0.016, Pe...... P-value = 0.016, Permutated P-value = 0.154 More... No significant asso...... No significant association was found More... Negative
rs7090018 - rs11199993 G-G FGFR2 Wang, T.,2012
P-value = 0.103, Pe...... P-value = 0.103, Permutated P-value = 0.664 More... No significant asso...... No significant association was found More... Negative
P-value = 0.951, Pe...... P-value = 0.951, Permutated P-value = 1.000 More... No significant asso...... No significant association was found More... Negative
rs7090018 - rs11199993 T-G FGFR2 Wang, T.,2012
P-value=0.835, Perm...... P-value=0.835, Permutated P-value=1 More... No significant asso...... No significant association was found. More... Negative
P-value=0.041, Perm...... P-value=0.041, Permutated P-value=0.347 More... No significant asso...... No significant association was found after permutation. More... Positive
rs7090018 - rs11199993 T-C FGFR2 Wang, T.,2012
P-value=0.112, Perm...... P-value=0.112, Permutated P-value=0.698 More... No significant asso...... No significant association was found. More... Negative
P-value=0.016, Perm...... P-value=0.016, Permutated P-value=0.154 More... No significant asso...... No significant association was found after permutation. More... Positive
rs7090018 - rs11199993 G-G FGFR2 Wang, T.,2012
P-value=0.103, Perm...... P-value=0.103, Permutated P-value=0.664 More... No significant asso...... No significant association was found. More... Negative
P-value=0.915, Perm...... P-value=0.915, Permutated P-value=1 More... No significant asso...... No significant association was found after permutation. More... Negative

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Last update: March 31, 2016