Study Report

Basic Info
Citation Gratacos, M., J. Costas, et al. (2009). Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Am J Med Genet B Neuropsychiatr Genet 150B(6): 808-816.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size Total 3214 samples consisited of 2277 cases(203 with Bipolar Disorder,422 with Major Depression,168 with Obsessive-Compulsive Disorder,173 with Panic Disorder,229 with Eating Disorders,917 with Schizophrenia and other Psychotic disorders and 165 with Substance Abuse) and 937 controls(330 from Madrid and 607 from Reus)
SNP/Region/Marker Size 748 SNPs
Predominant Ethnicity Caucasian
Population Spainish
Gender Males:44.3% in Bipolar Disorder cases,32.7% in Major Depression cases,34.0% in Obsessive-Compulsive Disorder cases,24.1% in Panic Disorder cases,7.4% in Eating Disorders cases,65.4% in Schizophrenia and other Psychotic disorders cases,72.6% in Substance Abuse cases,56.1% in Control Subset 1 (Madrid) and 51.7% in Control Subset 2 (Reus)
Age Group Adults : Mean Age(SD)(years):44.96(14.60)in Bipolar Disorder cases,49.55(17.37) in Major Depression cases,35.92(11.22) in Obsessive-Compulsive Disorder cases,36.02(10.11) in Panic Disorder cases,24.42(6.42) in Eating Disorders cases,45.59(16.74) in Schizophrenia and other Psychotic disorders cases,39.0(14.3) in Substance Abuse cases,38.3(14.3) in Control Subset 1 (Madrid) and 46.8(16.49) in Control Subset 2 (Reus)

Detail Info

SNPs reported by this study for BD (count: 21)

Other variants reported by this study for BD (count: 3)

Genes reported by this study for BD (count: 22)