SNP Report

Basic Info

Name	rs6999100 dbSNP Ensembl
Location	chr8:66170497 - 66170497(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.39357
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000276573, ENST00000315962, ENST00000350034, ENST00000353317, ENST00000517647); non_coding_transcript_variant(ENST00000517647)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Gratacos, M.,2009			Single SNP association: In control and bipolar disorder samp...... Single SNP association: In control and bipolar disorder samples: Recessive Model, P-value = 0.0201(corrected by genomic control, Reus), P-value = 0.0057(passed multiple testing correction, Madrid); OR(95% CI): Reus: 3.48 (1.39-8.69), Madrid: 5.53 (1.50-20.33) More...	Nominal statistical significance was observed as P-value < 0...... Nominal statistical significance was observed as P-value < 0.05 using both control sets under the same genotypic mode. More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TRIM55	tripartite motif containing 55	8q13.1	Mapped by Literature SNP
CRH	corticotropin releasing hormone	8q13	2(1/1/0)

SNPs in LD with rs6999100 (count: 5) View in gBrowse (chr8:66138330..66202329 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs4613981	downstream_gene_variant	1.0[CEU]
rs7825257	intron_variant	0.899[CEU]
rs1870394	upstream_gene_variant	1.0[CEU]
rs1870393		1.0[CEU]
rs10808748		1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)