SNP Report

Basic Info

Name	rs2281180 dbSNP Ensembl
Location	chr1:176894700 - 176894700(1)
Variant Alleles	G/A/C
Ancestral Allele	C
Minor Allele	G
Minor Allele Frequence	0.170727
Functional Annotation	missense_variant; synonymous_variant. Polyphen Annotation: benign(ENST00000361833, ENST00000367657, ENST00000424564) SIFT Annotation: tolerated(ENST00000361833, ENST00000367657, ENST00000424564)
Consequence to Transcript	missense_variant(ENST00000361833, ENST00000367657, ENST00000424564); synonymous_variant(ENST00000361833, ENST00000367657, ENST00000424564)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Gratacos, M.,2009			Single SNP association: In control and bipolar disorder samp...... Single SNP association: In control and bipolar disorder samples: Recessive Model, P-value = 0.0012(corrected by genomic control, Reus), P-value = 0.0293(passed multiple testing correction, Madrid); OR(95% CI): Reus: 4.87 (2.07-11.45), Madrid: 2.63 (1.12-6.20) More...	Nominal statistical significance was observed as P-value < 0...... Nominal statistical significance was observed as P-value < 0.05 using both control sets under the same genotypic mode. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ASTN1	astrotactin 1	1q25.2	1(1/0/0)

SNPs in LD with rs2281180 (count: 21) View in gBrowse (chr1:176779000..176908737 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs10442617	intron_variant	1.0[CEU]
rs6425398	3_prime_UTR_variant; intron_variant	1.0[CEU]
rs4652205	intron_variant	1.0[CEU]
rs6679355	intron_variant	1.0[CEU]
rs2206316	intron_variant	1.0[CEU]
rs7555335	intron_variant	1.0[CEU]
rs6679170	intron_variant	1.0[CEU]
rs2076341	intron_variant	1.0[CEU]
rs2228956	missense_variant	0.943[CEU]
rs6685449	intron_variant	1.0[CEU]
rs2206319	intron_variant	1.0[CEU]
rs4652201	intron_variant	1.0[CEU]
rs2072936	intron_variant	1.0[CEU]
rs1555068	intron_variant	1.0[CEU]
rs4652199	intron_variant	1.0[CEU]
rs4652192	intron_variant	0.883[CEU]
rs2072935	intron_variant; splice_region_variant	1.0[CEU]
rs2206318	downstream_gene_variant	1.0[CEU]
rs4652196	downstream_gene_variant; intron_variant	1.0[CEU]
rs2205889	intron_variant	1.0[CEU]
rs6425397	3_prime_UTR_variant; intron_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)