BDgene

KEGG Pathway Report

Basic Info
ID hsa04010
Name MAPK signaling pathway
No. of Genes in BDgene  39
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
MAPK signaling pathway PBA paper Chen, L., 2009 WTCCC Prioritizing Risk Pathways fusing SNPs and pathways (PRP) risk score=0.84
MAPK signaling pathway PBA paper Peng, G., 2010 WTCCC hypergeometric test (Fisher's exact test), Sidak's method, Simes' method, Simes/FDR method Simes/FDR P-value=0.0000502134

Pathway related genes in BDgene (count: 39)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 1(0/1/0)
EGFR epidermal growth factor receptor 7p12 1(0/0/1)
MAPK10 mitogen-activated protein kinase 10 4q22-q23 1(0/1/0)
HSPA1A heat shock 70kDa protein 1A 6p21.3 2(2/0/0)
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 1(1/0/0)
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 8p21.3 1(0/1/0)
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 17q24 2(1/1/0)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 7p22 1(1/0/0)
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 17q24 1(0/1/0)
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 12p13.33 1(1/0/0)
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0)
CDC25B cell division cycle 25B 20p13 1(0/1/0)
PLA2G1B phospholipase A2, group IB (pancreas) 12q24.31 4(1/3/0)
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 3(2/1/0)
ARRB2 arrestin, beta 2 17p13 1(1/0/0)
BDNF brain-derived neurotrophic factor 11p14.1 37(24/12/1)
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 22q13.1 3(3/0/0)
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 5q13 1(0/0/1)
GNA12 guanine nucleotide binding protein (G protein) alpha 12 7p22.3 1(1/0/0)
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1p36.1 1(0/1/0)
DUSP6 dual specificity phosphatase 6 12q22-q23 5(3/2/0)
FGF12 fibroblast growth factor 12 3q28 1(0/1/0)
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 12q13 1(0/0/1)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 2(1/1/0)
IL1B interleukin 1, beta 2q14 1(1/0/0)
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 1(1/0/0)
ATF4 activating transcription factor 4 22q13.1 1(1/0/0)
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 7q21-q22 2(0/0/2)
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25.3 1(1/0/0)
NF1 neurofibromin 1 17q11.2 1(1/0/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0)
TAOK2 TAO kinase 2 16p11.2 1(0/1/0)
NGF nerve growth factor (beta polypeptide) 1p13.1 2(1/1/0)
TNF tumor necrosis factor 6p21.3 4(2/2/0)
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 10q22.2 2(1/1/0)
MAP2K6 mitogen-activated protein kinase kinase 6 17q 1(0/1/0)
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 22q13.33 1(0/1/0)
FGFR2 fibroblast growth factor receptor 2 10q25.3-q26 2(1/1/0)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 3(1/1/1)