Study Report
Basic Info
| Reference |
Nishiguchi, N., 2006 PMID: 16289783
|
| Citation |
Nishiguchi, N., G. Breen, et al. (2006). "Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder." Neurosci Lett 394(3): 243-245.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
280 patients and 407 community dwelling controls |
| SNP/Region/Marker Size |
5 polymorphisms |
| Predominant Ethnicity |
Caucasian |
| Population |
British and Scottish |
| Gender |
age 50.3 years, SD=14.01 |
| Age Group |
adults
:
42% male
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
The study population consisted of 280 patients who met the bipolar I disorder criteria of DSM-IV (Diagnostic and Statistical Manual version IV). They were recruited for molecular genetic studies from psychiatric outpatient and lithium clinics in England and Scotland. |
| Technique |
genotyping |
| Statistical Method |
Differences in the genotype and allele frequencies between patients and controls were tested for significance using a chi-square test. |
| Result Summary |
Of the five polymorphisms we examined, three were very rare in the study population and were not examined further. Neither of the remaining two polymorphisms we examined showed association with bipolar disorder. Thus, it is unlikely that the GSK3beta-gene is a risk factor for bipolar disorder in our sample, but we cannot exclude the gene completely as other unknown polymorphisms in the gene may increase susceptibility. |
Other variants reported by this study for BD (count: 2)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| GSK3B -1727A/T |
GSK3B |
point mutation |
A/T |
|
allelic P-value = 0.468, X2=0.549, d.f.=1, OR=0.7530 (95% CI 0.5514-1.028); genotypic P-value = 0.355, X2=1.891, d.f.=2
|
There was no difference in the allele and genotype frequenci......
There was no difference in the allele and genotype frequencies of the -1727A/T between the bipolar disorders and the controls.
More...
|
Negative
|
| GSK3B -50T/C |
GSK3B |
point mutation |
T/C |
|
allelic P-value = 0.646, X2=0.265, d.f.=1, OR=0.9425 (95% CI 0.7524-1.181); genotypic P-value = 0.449, X2=1.609, d.f.=2
|
There was no difference in the allele and genotype frequenci......
There was no difference in the allele and genotype frequencies of the -50T/C between the bipolar disorders and the controls.
More...
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| GSK3B |
It is unlikely that the GSK3beta-gene is a risk factor for bipolar disorder in our sample, but we ca......
It is unlikely that the GSK3beta-gene is a risk factor for bipolar disorder in our sample, but we cannot exclude the gene completely as other unknown polymorphisms in the gene may increase susceptibility.
More...
|
Negative
|
