BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Meta-analysis Report

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Basic Info

Reference	Chen G., 2014 PMID: 24929537
Citation	Chen, G., et al. (2014). "Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder." Mol Biol Rep.
Disease Type	Bipolar Disorder
Study Type	Candidate-gene association study

Detail Info

Samples	6 publications including 1,251 cases and 1,804 controls
Statistic Method	For each study, Hardy-Weinberg equilibrium (HWE) for controls was re-assessed by X² test with an eligible threshold of P<=0.01; Crude ORs and their 95%CIs were used to measure the association strength of GSK3B-50C/T with BD risk. Heterogeneity assumption was examined by Cochran's Q test and then quantified by I² statistic; a P value greater than 0.10 or I² less than 50% indicated a lack of significant heterogeneity among studies. The pooled estimates including pooled OR and pooled SMD were calculated by a fixed-effects model or a random-effects model according to the heterogeneity. Begg's funnel plot and Egger's test were performed to measure the potential publication bias. Sensitivity analysis was used to evaluate the results' stability by recalculating the pooled estimate after omitting each study at a time. All the statistical analyses were executed by Stata/SE version 11.2 (Stata Corporation, College Station, TX). P values less than 0.05 were considered significant, unless specifically stated. In addition, we evaluated our study power via PASS 2008 version 08.0.16 (NCSS, LLC. Kaysville, Utah, USA).
Basic Result	A total of 6 publications including 1,251 cases and 1,804 controls were identified to investigate the effect of GSK3B-50C/T on BD risk, and found no significant association in any genetic models (C vs. T: OR=1.03, 95%CI: 0.92-1.15; CC vs. TT+TC: OR=1.04, 95%CI: 0.84-1.28; TC+CC vs. TT: OR=1.16, 95%CI: 0.97-1.39; and CC vs. TC vs. TT: OR=1.08, 95%CI: 0.96-1.22). Subgroup analysis by ethnicity did not change the results. The association between GSK3B -50C/T and age at onset of BD was explored by 6 identified studies with a total of 659 BD type I patients. Similarly, we did not observe significant results in any genetic models(TC+CC vs. TT: SMD=0.20, 95%CI: -0.07 to 0.47; CC vs. TT?TC: SMD=0.11, 95%CI: -0.10 to 0.32; CC vs. TT: SMD=0.32, 95%CI: -0.13 to 0.77). The power analysis and tests for publication bias ensured the reliability of our results. In summary, this meta-analysis suggests that the functional polymorphism -50C/T within the GSK3B gene promoter is unlikely to relate with BD risk.

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs334558	GSK3B	C/T		C vs. T: Asians: OR=1.15, 95%CI=0.95-1.39, P_{heterogeneity}-value=0.959, I²=0.0; Caucasians: OR=0.98, 95%CI=0.86-1.11, P_{heterogeneity}-value=0.208, I²=36.2%; Overall: OR=1.03, 95%CI=0.92-1.15, P_{heterogeneity}-value=0.393, I²=3.7%. CC vs. TT+TC: OR=1.09, 95%CI=0.82-1.44, P_{heterogeneity}-value=0.925, I²=0.0; Caucasians: OR=0.97, 95%CI=0.71-1.33, P_{heterogeneity}-value=0.444, I²=0.0; Overall: OR=1.04, 95%CI=0.84-1.28, P_{heterogeneity}-value=0.905, I²=0.0. TC+CC vs. TT: Asians: OR=1.48, 95%CI=1.01-2.17, P_{heterogeneity}-value=0.987, I²=0.0; Caucasians: OR=1.06, 95%CI=0.70-1.59, P_{heterogeneity}-value=0.052, I²=73.6%; Overall: OR=1.16, 95%CI=0.97-1.39, P_{heterogeneity}-value=0.202, I²=32.9%. CC vs. TC vs. TT: Asians: OR=1.17, 95%CI=0.96-1.42, P_{heterogeneity}-value=0.934, I²=0.0; Caucasians: OR=1.03, 95%CI=0.88-1.21, P_{heterogeneity}-value=0.286, I²=12.0%; Overall: OR= 1.08, 95%CI=0.96-1.22, P_{heterogeneity}-value=0.705, I²=0.0.	We identified a total of 6 publications including 1,251 case...... We identified a total of 6 publications including 1,251 cases and 1,804 controls to investigate the effect of GSK3B-50C/T on BD risk, and found no significant association in any genetic models. More...	Negative

Genes reported by this study for BD (count: 1)