KEGG Pathway Report

Basic Info
ID hsa04510
Name Focal adhesion
No. of Genes in BDgene  22
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
Focal adhesion PBA paper Peng, G., 2010 WTCCC hypergeometric test (Fisher's exact test), Sidak's method, Simes' method, Simes/FDR method Fisher exact test P-value=0.0116289
Focal adhesion PBA paper Chen, L., 2009 WTCCC Prioritizing Risk Pathways fusing SNPs and pathways (PRP) risk score=0.58

Pathway related genes in BDgene (count: 22)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DIAPH1 diaphanous-related formin 1 5q31 1(1/0/0)
EGFR epidermal growth factor receptor 7p12 1(0/0/1)
MAPK10 mitogen-activated protein kinase 10 4q22-q23 1(0/1/0)
ITGA9 integrin, alpha 9 3p21.3 1(1/0/0)
VCL vinculin 10q22.1-q23 1(0/0/1)
PARVG parvin, gamma 22q13.31 1(1/0/0)
LAMA3 laminin, alpha 3 18q11.2 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 8(0/8/0)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 7p22 1(1/0/0)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 7q22 1(0/0/1)
ITGB6 integrin, beta 6 2q24.2 1(1/0/0)
PARVB parvin, beta 22q13.2-q13.33 1(1/0/0)
TNR tenascin R 1q24 2(0/2/0)
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0)
COL11A2 collagen, type XI, alpha 2 6p21.3 1(1/0/0)
BCL2 B-cell CLL/lymphoma 2 18q21.3 2(0/2/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 1(1/0/0)
IGF1 insulin-like growth factor 1 (somatomedin C) 12q23.2 1(1/0/0)
RELN reelin 7q22 3(1/2/0)
LAMB1 laminin, beta 1 7q22 1(0/0/1)
FYN FYN proto-oncogene, Src family tyrosine kinase 6q21 1(1/0/0)
ITGB8 integrin, beta 8 7p15.3 1(1/0/0)