BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Lin YF, 2013 PMID: 23021822
Citation	Lin, Y. F., M. C. Huang, et al. (2013). "Glycogen synthase kinase 3beta gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium." J Affect Disord 147(1-3): 401-406.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	138 Taiwanese bipolar I disorder patients and 131 controls
SNP/Region/Marker Size	2 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	71 male and 67 female in patients;65 male and 66 female in controls
Age Group	adults : Mean age(SD)(year):39.6(10.7) for BD patients;39.3(10.3) for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	We enrolled 138 bipolar I disorder patients from Taipei City Psychiatric Center,Taipei City Hospital,Taiwan.The patients were diagnosed according to DSM-IV criteria with consensus of at least two experienced psychiatrists on the basis of a SCID interview(First, 1996) and a review of medical records.Exclusion criteria were additional DSM-IV Axis I diagnoses(including schizophrenia, schizoaffective disorder,major depressive disorder,substance use disorder,anxiety disorders),personality disorders and major medical and/or neurological disorders.One hundred and thirty-one age-and sex-matched healthy controls were also recruited in this study after a psychiatric interview to rule out past or present bipolar disorder,major depressive disorder,schizophreniaor schizoaffective disorder.
Technique	Genotyping
Statistical Method	chi-square tests
Result Summary	We found no association between each of the two SNPs and the risk of bipolar I disorder. Following correction for multiple testing, CT genotype at rs6438552 was associated with an older age of onset than other genotypes (P=0.042) in female patients. Patients with genotype TT at rs334558 (P=0.044) had poorer response to lithium treatment. There was a trend that haplotype C-T increased the risk for bipolar I disorder (adjusted OR=4.22, corrected P=0.084), and patients with haplotype T-T had poorer treatment response to lithium than those with haplotype C-C. LIMITATIONS: Limitations included small sample size, retrospective data collection, and a potential sampling bias. CONCLUSIONS: Despite the several limitations of the study, our results suggested GSK-3beta genetic variants may be associated with the risk of bipolar I disorder, age of disease onset in females, and the therapeutic response to lithium.

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs334558	GSK3B	C/T		Chi square test:genotype,P-value = 0.459,chi square = 1.588;allele,P-value = 0.461,chi square = 0.543	No significant association was observed. No significant association was observed.	Negative
rs6438552	GSK3B	C/T		Chi square test:genotype,P-value = 0.399,chi square = 1.839;allele,P-value = 0.959,chi square = 0.003	No significant association was observed. No significant association was observed.	Negative

Haplotypes reported by this study for BD (count: 4)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs334558 - rs6438552	C-C	GSK3B	no P-value	No significant association was observed. No significant association was observed.	Negative
rs334558 - rs6438552	T-T	GSK3B	P-value=0.571, OR (95%CI)=0.9 (0.62, 1.30); adjusted P-value=0.57, OR (95%CI)=0.9 (0.55, 1.47)	No significant association was observed. No significant association was observed.	Negative
rs334558 - rs6438552	T-C	GSK3B	P-value=0.473, OR (95%CI)=1.48 (0.51, 4.28); adjusted P-value=0.49, OR (95%CI)=1.46 (0.50, 4.28)	No significant association was observed. No significant association was observed.	Negative
rs334558 - rs6438552	C-T	GSK3B	P-value=0.013, OR (95%CI)=4.18 (1.35, 12.96); adjusted P-value=0.014, OR (95%CI)=4.22 (1.34, 13.25)	Compared to the most frequent haplotype C-C, a rare haplotyp...... Compared to the most frequent haplotype C-C, a rare haplotype C-T was associated with an increased risk for bipolar I disorder. However, these significant effects disappeared after FDR correction. More...	Positive

Genes reported by this study for BD (count: 1)