Gene Report

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Basic Info

Approved Symbol	PPP1R2
Symbol Alias	IPP2
Approved Name	protein phosphatase 1, regulatory (inhibitor) subunit 2
Location	3q29
Position	chr3:195514425-195543386, -1
External Links	HGNC: 9288 Entrez Gene: 5504 Ensembl: ENSG00000184203 UCSC: uc032sob.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs11475, rs823512 Haplotype: rs823512 - rs11475(A-C)	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043086	negative regulation of catalytic activity	biological process	IEA; TAS[8119416]	5
GO:0043666	regulation of phosphoprotein phosphatase activity	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[10807923]	563
GO:0004865	protein serine/threonine phosphatase inhibitor activity	molecular function	TAS[8119416]	2
GO:0009966	regulation of signal transduction	biological process	IEA	4
GO:0006091	generation of precursor metabolites and energy	biological process	TAS[9126490]	5
GO:0005977	glycogen metabolic process	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP1R2	NEK2	NO	in vitro;in vivo;yeast 2-hybrid	12221103
PPP1R2	CDK5	NO	in vivo	11320080
PPP1R2	CSNK2A2	NO	in vitro	8288648
PPP1R2	PPP1CA	NO	in vitro	10807923
PPP1R2	LMTK2	NO	in vitro;in vivo	12393858
PPP1R2	PPP1R9B	NO	in vitro	12270929
PPP1R2	PPP1CC	NO	in vitro	10807923

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11475	chr3:195543189 - 195543189(1)	5_prime_UTR_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs823512	chr3:195537313 - 195537313(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs823508	chr3:195535470 - 195535470(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2259661	chr3:195530369 - 195530369(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2641378	chr3:195519502 - 195519502(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs2641381	chr3:195518229 - 195518229(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs823513	chr3:195537438 - 195537438(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs860317	chr3:195537041 - 195537041(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs861098	chr3:195537016 - 195537016(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs35901045	chr3:195509651 - 195509651(1)	downstream_gene_variant
rs823499	chr3:195513874 - 195513874(1)	downstream_gene_variant
rs2686439	chr3:195517728 - 195517728(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:195514425..195543386 View in gBrowse