Gene Report

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Basic Info

Approved Symbol	PPP1R2
Symbol Alias	IPP2
Approved Name	protein phosphatase 1, regulatory (inhibitor) subunit 2
Location	3q29
Position	chr3:195514425-195543386, -1
External Links	HGNC: 9288 Entrez Gene: 5504 Ensembl: ENSG00000184203 UCSC: uc032sob.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs11475, rs823512 Haplotype: rs823512 - rs11475(A-C)	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043086	negative regulation of catalytic activity	biological process	IEA; TAS[8119416]	5
GO:0043666	regulation of phosphoprotein phosphatase activity	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[10807923]	563
GO:0004865	protein serine/threonine phosphatase inhibitor activity	molecular function	TAS[8119416]	2
GO:0009966	regulation of signal transduction	biological process	IEA	4
GO:0006091	generation of precursor metabolites and energy	biological process	TAS[9126490]	5
GO:0005977	glycogen metabolic process	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP1R2	PPP1R9B	NO	in vitro	12270929
PPP1R2	PPP1CA	NO	in vitro	10807923
PPP1R2	CSNK2A2	NO	in vitro	8288648
PPP1R2	CDK5	NO	in vivo	11320080
PPP1R2	LMTK2	NO	in vitro;in vivo	12393858
PPP1R2	NEK2	NO	in vitro;in vivo;yeast 2-hybrid	12221103
PPP1R2	PPP1CC	NO	in vitro	10807923

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11475	chr3:195543189 - 195543189(1)	5_prime_UTR_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs823512	chr3:195537313 - 195537313(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs823508	chr3:195535470 - 195535470(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2259661	chr3:195530369 - 195530369(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2641378	chr3:195519502 - 195519502(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs2641381	chr3:195518229 - 195518229(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs823513	chr3:195537438 - 195537438(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs860317	chr3:195537041 - 195537041(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs861098	chr3:195537016 - 195537016(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs35901045	chr3:195509651 - 195509651(1)	downstream_gene_variant
rs823499	chr3:195513874 - 195513874(1)	downstream_gene_variant
rs2686439	chr3:195517728 - 195517728(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:195514425..195543386 View in gBrowse