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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Gonzalez, S., 2014 PMID: 25044503 |
|---|---|
| Citation | Gonzalez, S., et al. (2014). "A genome-wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32." Am J Med Genet B Neuropsychiatr Genet 165B(6): 479-491. |
| Disease Type | Bipolar Disorder |
| Study Design | family-based |
| Study Type | Genome-wide linkage study |
| Sample Size | 3757 participants included 963 individuals with BP phenotype (704 relative pairs) from 686 families, 393 ethnically matched healthy Latino individuals |
| SNP/Region/Marker Size | 5913 SNPs |
| Predominant Ethnicity | Caucasian |
| Population | US, Mexico, Costa Rica and Guatemala |
Detail Info
| Sample Diagnosis | DSM-IV |
|---|---|
| Sample Status | The present report includes 3757 subjects, including Latinos of Mexican and Central American ancestry with BPI, SABP and when available, their parents and siblings. Each family recruited for the study had at least two siblings who had been previously diagnosed with either BPI or SABP (according to inpatient or outpatient records). Criteria for participation in the study included having at least two of the four grandparents reporting ancestry from Mexico or Central America (Guatemala, Costa Rica, Honduras, or El Salvador). All participants, regardless of diagnostic or family status, were interviewed using the Diagnostic Interview for Genetic Studies (DIGS), by bilingual (English/ Spanish) psychiatrists/psychologists who had participated in interrater reliability trainings with this research consortium. Interviews were conducted in each participants' language of preference (English or Spanish), using version 2.0 of the DIGS. Final diagnoses were determined through a best estimation process in which two bilingual psychiatrists or psychologists reviewed the DIGS and FIGS for each individual, along with any available records including any available hospitalization or treatment records. |
| Technique | Genotyping was performed at the Center for Inherited Disease Research (CIDR) using the Illumina HumanLinkage-24 BeadChip (Illumina Inc., San Diego, CA), with an average genetic coverage of 0.67 cM. |
| Statistical Method | Non-parametric affected sibling pair analyses were performed over a 5 cM grid using the linkage analysis software MERLIN. Multipoint analyses, which increase the linkage information at each map position, were conducted across the genome using non-parametric Kong & Cox LOD (NPL) scores along with Sall statistics for all relative pairs. The approach for modeling marker-marker linkage disequilibrium during multipoint analysis, as described by Abecasis and Wigginton, was performed by clustering markers using a pair-wise r2 value of 0.1 using the MERLIN software. For purposes of interpretation of significance, the genome-wide significance level was calculated from 1000 simulations using simulated genomes generated by the genedropping algorithm in MERLIN. The genome-wide significance level, represented by the empirical P value, was computed using the conservative estimate of P, P=(r+1)/(n+1), where r is the number of times a NPL-Z score greater than or equal to the observed maximum NPL-Z is noted in a simulated sample with n simulations, in which r exceed the observed statistic obtained from the real data set. |
| Result Summary | We identified two genome-wide significant susceptibly loci for BP at 8q24 and 14q32, and a third suggestive locus at 2q13-q14. Within these three linkage regions, the top associated single marker (rs1847694, P-value=2.40E-05) is located 195 Kb upstream of DPP10 in Chromosome 2. DPP10 is prominently expressed in brain neuronal populations, where it has been shown to bind and regulate Kv4-mediated A-type potassium channels. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs1847694 | DPP10 | Test for linkage: LOD=1.07, P-value=0.18; Test for association: LOD=3.88, P-value=2.40E-05; Test for other linked variants: LOD=1.26, P-value=0.055 | The most significantly associated marker was rs1847694, whic...... The most significantly associated marker was rs1847694, which is located 195 Kb upstream of DPP10 in Chromosome 2. More... | Positive | ||
| rs10180987 | DPP10 | Test for linkage: LOD=1.29, P-value=0.114; Test for association: LOD=0.27, P-value=0.27; Test for other linked variants: LOD=0.99, P-value=0.102 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1372823 | LOC100533709 | Test for linkage: LOD=0.69, P-value=0.37; Test for association: LOD=0.51, P-value=0.125; Test for other linked variants: LOD=0.82, P-value=0.15 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1516003 | DDX18 | Test for linkage: LOD=0.6, P-value=0.43; Test for association: LOD=0.44, P-value=0.15; Test for other linked variants: LOD=0.73, P-value=0.19 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs744531 | MIR4435-1HG BCL2L11 | Test for linkage: LOD=1.03, P-value=0.19; Test for association: LOD=0.15, P-value=0.41; Test for other linked variants: LOD=1.15, P-value=0.071 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs934748 | CHCHD5 SLC20A1 | Test for linkage: LOD=0.45, P-value=0.55; Test for association: LOD=1.56, P-value=0.007; Test for other linked variants: LOD=0.77, P-value=0.17 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs2048876 | NT5DC4 | Test for linkage: LOD=0.42, P-value=0.59; Test for association: LOD=2.54, P-value=6.20E-04; Test for other linked variants: LOD=0.64, P-value=0.23 | Three other SNPs in Chromosome 2 had significant p-values: r...... Three other SNPs in Chromosome 2 had significant p-values: rs1864474 located within SH3RF3 gene, rs2048876 within NT5DC4, and rs708670 within STEAP3. More... | Trend | ||
| rs895415 | PAX8 | Test for linkage: LOD=2.38, P-value=0.012; Test for association: LOD=0.38, P-value=0.19; Test for other linked variants: LOD=1.42, P-value=0.038 | It showed little evidence for association with BD. It showed little evidence for association with BD. | Trend | ||
| rs748856 | ZHX2 | Test for linkage: LOD=2.09, P-value=0.022; Test for association: LOD=1.65, P-value=0.006; Test for other linked variants: LOD=2.21, P-value=0.006 | It showed little evidence for association with BD. It showed little evidence for association with BD. | Trend | ||
| rs2833 | ZHX2 | Test for linkage: LOD=0.68, P-value=0.37; Test for association: LOD=0.1, P-value=0.5; Test for other linked variants: LOD=0.67, P-value=0.21 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs4870888 | FER1L6 FER1L6-AS2 | Test for linkage: LOD=0.68, P-value=0.37; Test for association: LOD=0.75, P-value=0.063; Test for other linked variants: LOD=0.72, P-value=0.19 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs10956248 | TRIB1 | Test for linkage: LOD=0.92, P-value=0.24; Test for association: LOD=0.31, P-value=0.23; Test for other linked variants: LOD=0.67, P-value=0.21 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1025736 | MARCO | Test for linkage: LOD=0.21, P-value=0.81; Test for association: LOD=1.06, P-value=0.027; Test for other linked variants: LOD=0.47, P-value=0.34 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs708670 | STEAP3 | Test for linkage: LOD=0.09, P-value=0.94; Test for association: LOD=2.54, P-value=6.30E-04; Test for other linked variants: LOD=0, P-value=0.99 | Three other SNPs in Chromosome 2 had significant p-values: r...... Three other SNPs in Chromosome 2 had significant p-values: rs1864474 located within SH3RF3 gene, rs2048876 within NT5DC4, and rs708670 within STEAP3. More... | Trend | ||
| rs895406 | STEAP3 STEAP3-AS1 | Test for linkage: LOD=0.45, P-value=0.56; Test for association: LOD=0.56, P-value=0.108; Test for other linked variants: LOD=0.12, P-value=0.76 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1880542 | INHBB GLI2 | Test for linkage: LOD=0.77, P-value=0.32; Test for association: LOD=0.86, P-value=0.047; Test for other linked variants: LOD=0.9, P-value=0.126 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs737182 | MALL | Test for linkage: LOD=0.21, P-value=0.8; Test for association: LOD=1.25, P-value=0.017; Test for other linked variants: LOD=0.13, P-value=0.74 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1864474 | SH3RF3 | Test for linkage: LOD=1.12, P-value=0.16; Test for association: LOD=2.7, P-value=4.20E-04; Test for other linked variants: LOD=1.26, P-value=0.055 | Three other SNPs in Chromosome 2 had significant p-values: r...... Three other SNPs in Chromosome 2 had significant p-values: rs1864474 located within SH3RF3 gene, rs2048876 within NT5DC4, and rs708670 within STEAP3. More... | Trend | ||
| rs1439287 | ACOXL | Test for linkage: LOD=0.41, P-value=0.59; Test for association: LOD=1.69, P-value=0.005; Test for other linked variants: LOD=0.28, P-value=0.53 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs729386 | ACOXL | Test for linkage: LOD=0.71, P-value=0.35; Test for association: LOD=0.38, P-value=0.19; Test for other linked variants: LOD=0.6, P-value=0.25 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs872945 | CDC42BPB | Test for linkage: LOD=0, P-value=1; Test for association: LOD=0.06, P-value=0.61; Test for other linked variants: LOD=0, P-value=0.99 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs8548 | ZFYVE21 PPP1R13B | Test for linkage: LOD=0.38, P-value=0.63; Test for association: LOD=0.49, P-value=0.134; Test for other linked variants: LOD=0.33, P-value=0.47 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs4900525 | PPP2R5C DYNC1H1 | Test for linkage: LOD=1.24, P-value=0.127; Test for association: LOD=0.67, P-value=0.078; Test for other linked variants: LOD=1.59, P-value=0.026 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs4906236 | RCOR1 | Test for linkage: LOD=0.88, P-value=0.25; Test for association: LOD=0.48, P-value=0.139; Test for other linked variants: LOD=1.11, P-value=0.078 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1132975 | SIVA1 | Test for linkage: LOD=0, P-value=1; Test for association: LOD=0.52, P-value=0.123; Test for other linked variants: LOD=0.45, P-value=0.35 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs2841245 | CEP170B | Test for linkage: LOD=0, P-value=1; Test for association: LOD=0.36, P-value=0.2; Test for other linked variants: LOD=0, P-value=1 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1547350 | KIF26A | Test for linkage: LOD=0.1, P-value=0.93; Test for association: LOD=0.2, P-value=0.34; Test for other linked variants: LOD=0.04, P-value=0.92 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs6644 | ADSSL1 | Test for linkage: LOD=1.1, P-value=0.17; Test for association: LOD=0.3, P-value=0.24; Test for other linked variants: LOD=0.59, P-value=0.26 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs988131 | IGHV3-71 IGH | Test for linkage: LOD=0.07, P-value=0.96; Test for association: LOD=0.45, P-value=0.15; Test for other linked variants: LOD=0 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1858691 | IGHVII-74-1 IGHV3-75 IGHV3-76 IGH | Test for linkage: LOD=0, P-value=1; Test for association: LOD=0.5, P-value=0.128; Test for other linked variants: LOD=0.1, P-value=0.8 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs10151805 | C14orf80 | Test for linkage: LOD=0.99, P-value=0.21; Test for association: LOD=0.05, P-value=0.63; Test for other linked variants: LOD=0.88, P-value=0.131 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs988133 | IGHV3-71 IGH | Test for linkage: LOD=0.42, P-value=0.59; Test for association: LOD=0.39, P-value=0.18; Test for other linked variants: LOD=0.41, P-value=0.39 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1544317 | IGHV7-81 IGH | Test for linkage: LOD=0.1, P-value=0.93; Test for association: LOD=0.18, P-value=0.36; Test for other linked variants: LOD=0.05, P-value=0.88 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs2105992 | IGHV5-78 IGH | Test for linkage: LOD=0.25, P-value=0.77; Test for association: LOD=0.14, P-value=0.42; Test for other linked variants: LOD=0.17, P-value=0.68 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs4774028 | IGHV5-78 IGH | Test for linkage: LOD=0.73, P-value=0.34; Test for association: LOD=0.02, P-value=0.79; Test for other linked variants: LOD=0.59, P-value=0.26 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs7814955 | FAM84B | Test for linkage: LOD=0.96, P-value=0.22; Test for association: LOD=0.66, P-value=0.082; Test for other linked variants: LOD=1.26, P-value=0.055 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1488019 | TRIB1 | Test for linkage: LOD=2.54, P-value=0.009; Test for association: LOD=0.15, P-value=0.4; Test for other linked variants: LOD=1.86, P-value=0.014 | It showed little evidence for association with BD. It showed little evidence for association with BD. | Trend | ||
| rs2124036 | TRIB1 | Test for linkage: LOD=1.56, P-value=0.066; Test for association: LOD=0.22, P-value=0.31; Test for other linked variants: LOD=1.57, P-value=0.027 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs921720 | TRIB1 | Test for linkage: LOD=0.37, P-value=0.63; Test for association: LOD=0.23, P-value=0.3; Test for other linked variants: LOD=0.52, P-value=0.3 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs755520 | PVT1 | Test for linkage: LOD=1.19, P-value=0.14; Test for association: LOD=0, P-value=0.91; Test for other linked variants: LOD=1, P-value=0.1 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs283710 | CCAT1 | Test for linkage: LOD=0.24, P-value=0.77; Test for association: LOD=0.6, P-value=0.098; Test for other linked variants: LOD=0.02, P-value=0.95 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs901592 | PCAT1 | Test for linkage: LOD=1.45, P-value=0.084; Test for association: LOD=1.63, P-value=0.006; Test for other linked variants: LOD=1.65, P-value=0.022 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs974450 | FAM84B | Test for linkage: LOD=0.63, P-value=0.4; Test for association: LOD=0.56, P-value=0.107; Test for other linked variants: LOD=0.65, P-value=0.22 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs3057 | ASAP1 | Test for linkage: LOD=0.88, P-value=0.26; Test for association: LOD=0.29, P-value=0.25; Test for other linked variants: LOD=0.94, P-value=0.114 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs298609 | FAM49B | Test for linkage: LOD=0.04, P-value=0.98; Test for association: LOD=0.38, P-value=0.18; Test for other linked variants: LOD=0.18, P-value=0.66 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs384752 | FAM49B | Test for linkage: LOD=0.06, P-value=0.97; Test for association: LOD=0.4, P-value=0.18; Test for other linked variants: LOD=0.2, P-value=0.63 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs766811 | LINC00977 | Test for linkage: LOD=0.85, P-value=0.27; Test for association: LOD=0.09, P-value=0.52; Test for other linked variants: LOD=0.88, P-value=0.132 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1007904 | DIO3 | Test for linkage: LOD=0.09, P-value=0.94; Test for association: LOD=0.55, P-value=0.112; Test for other linked variants: LOD=0.02, P-value=0.95 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs17172 | SNORD114-11 SNORD114-10 SNORD114-9 SNORD114-7 | Test for linkage: LOD=1.76, P-value=0.043; Test for association: LOD=0, P-value=0.9; Test for other linked variants: LOD=1.26, P-value=0.055 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs7159412 | MEG3 MIR2392 | Test for linkage: LOD=0.13, P-value=0.9; Test for association: LOD=0.16, P-value=0.39; Test for other linked variants: LOD=0.06, P-value=0.87 | No significant associations were observed. No significant associations were observed. | Negative | ||
| rs1951521 | YY1 | Test for linkage: LOD=0.55, P-value=0.47; Test for association: LOD=0.66, P-value=0.081; Test for other linked variants: LOD=0.83, P-value=0.146 | No significant associations were observed. No significant associations were observed. | Negative |
| Variant Name | Related Gene | Type | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|---|
| PTPN4 Chr2:120419158 | PTPN4 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| DPP10 Chr2:116314867 | DPP10 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| GLI2 Chr2:121464518 | GLI2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| GLI2 Chr2:121444612 | GLI2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| IL1RN Chr2:113594121 | IL1RN | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| IL36RN Chr2:113536607 | IL36RN | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| DPP10 Chr2:116251310 | DPP10 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ACTR3 Chr2:114401422 | ACTR3 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| IL1B Chr2:113304498 | IL1B | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| KLC1 Chr14:103193796 | KLC1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| KLC1 Chr14:103193859 | KLC1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| MARK3 Chr14:102985013 | MARK3 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| MARK3 Chr14:103002170 | MARK3 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| HSP90AA1 Chr14:101622401 | HSP90AA1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| RCOR1 Chr14:102250649 | RCOR1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| DYNC1H1 Chr14:101530331 | DYNC1H1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| DYNC1H1 Chr14:101533297 | DYNC1H1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| TRIB1 Chr8:126514759 | TRIB1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| MYC Chr8:128819709 | MYC | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ATAD2 Chr8:124451340 | ATAD2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| FBXO32 Chr8:124614644 | FBXO32 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ATAD2 Chr8:124419211 | ATAD2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ATAD2 Chr8:124440660 | ATAD2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ZHX1 Chr8:124336277 | ZHX1-C8orf76, ZHX1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| ZHX1 Chr8:124336599 | ZHX1-C8orf76, ZHX1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| MTA1 Chr14:105007547 | MTA1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| PACS2 Chr14:104904668 | PACS2 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| BRF1 Chr14:104763646 | BRF1 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| TDRD9 Chr14:103576402 | TDRD9 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend | ||||
| TDRD9 Chr14:103464808 | TDRD9 | Predicted Deleterious Variants Identified with Whole Genome ...... Predicted Deleterious Variants Identified with Whole Genome Sequencing. More... | Trend |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| TRIB1 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| STEAP3 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| ZFYVE21 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| YY1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| SH3RF3 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| RCOR1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| SNORD114-7 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| SIVA1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| ZHX2 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| LOC100533709 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| LINC00977 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| KIF26A | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| CCAT1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| INHBB | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| CEP170B | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| GLI2 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| IGH | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| PPP2R5C | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| PVT1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| PAX8 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| PCAT1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| MIR2392 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| NT5DC4 | It showed nominal evidence for association with BD. It showed nominal evidence for association with BD. | Trend |
| MALL | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| MARCO | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| CHCHD5 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| CDC42BPB | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| C14orf80 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| BCL2L11 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| ASAP1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| ADSSL1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| ACOXL | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| FER1L6 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| FAM84B | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| FAM49B | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| DYNC1H1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| DPP10 | Significant association of SNP in this gene with BD was observed. Significant association of SNP in this gene with BD was observed. | Positive |
| DIO3 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| DDX18 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| SLC20A1 | The associated SNP in this gene showed no significant association with BD. The associated SNP in this gene showed no significant association with BD. | Negative |
| Region | Statistical Values | Author Comments | Result Category |
|---|---|---|---|
| 2q13-q14_126.907cM | Linkage analysis: Non-Parametric Kong & Cox LOD: ZSCORE=2.929, LOD=2.256, P-value=6.33E-04, Empirical P-value=0.300; Sall Statistic: ZSCORE=2.690, LOD=1.914, P-value=1.50E-03, Empirical P-value=0.590. | A third region, 2q13-q14, showed suggestive evidence of link...... A third region, 2q13-q14, showed suggestive evidence of linkage (NPL > 1.71, Sall LOD > 1.68). More... | Trend |
| 14q32_116.416cM | Linkage analysis: Non-Parametric Kong & Cox LOD: ZSCORE=3.266, LOD=2.650, P-value=2.39E-04, Empirical P-value=0.122; Sall Statistic: ZSCORE=3.454, LOD=2.977, P-value=1.07E-04, Empirical P-value=0.049. | Two regions (8q24 and 14q32) revealed significantevidenceof ...... Two regions (8q24 and 14q32) revealed significantevidenceof linkage at NPLscores of 3.06 and/or Sall LOD 2.96 or higher (corresponding to empirical Pvalues below 0.05). More... | Trend |
| 8q24_130.000cM | Linkage analysis: Non-Parametric Kong & Cox LOD: ZSCORE=3.907, LOD=3.455, P-value=3.32E-05, Empirical P-value=0.018; Sall Statistic: ZSCORE=3.897, LOD=3.528, P-value=2.78E-05, Empirical P-value=0.013. | Two regions (8q24 and 14q32) revealed significantevidenceof ...... Two regions (8q24 and 14q32) revealed significantevidenceof linkage at NPLscores of 3.06 and/or Sall LOD 2.96 or higher (corresponding to empirical Pvalues below 0.05). More... | Positive |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016