Gene Report

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Basic Info

Approved Symbol	FAM49B
Symbol Alias	BM-009
Approved Name	family with sequence similarity 49, member B
Location	8q24.21
Position	chr8:129839593-130017129, -1
External Links	HGNC: 25216 Entrez Gene: 51571 Ensembl: ENSG00000153310 UCSC: uc003ysu.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs384752, rs298609	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005929	cilium	cellular component	IEA	10
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs384752	chr8:129865524 - 129865524(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs298609	chr8:129874349 - 129874349(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs1467048		chr8:130012301 - 130012301(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.21-qter	chr8:126300000-145138636	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr8:129839593..130017129 View in gBrowse