Study Report

Basic Info
Citation Scott, L. J., P. Muglia, et al. (2009). Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A 106(18): 7501-7506.
Disease Type Bipolar Disorder
Study Design case-control
Study Type Genome-wide association study
Sample Size (i) 2,076 bipolar cases and 1,676 controls of European ancestry from the National Institute of Mental Health Human Genetics Initiative Repository, and the Prechter Repository and samples collected in London, Toronto, and Dundee.(ii)1,868 BP cases and an expanded reference set of 12,831 individuals from the Wellcome Trust Case Control Consortium (WTCCC).
SNP/Region/Marker Size NIMH/Pritzker:541,327 SNPs;GSK: 521,990 SNPs;WTCCC:397,653 SNPs
Predominant Ethnicity Caucasian
Population NIMH/Pritzker,GSK and WTCCC collection
Gender females proportion:62.8% in cases and 50.3% in controls in NIMH/Pritzker samples,in cases(64.2% in complete sample,64.9% in reduced sample) and 58.6% in controls in GSK samples,63% in cases and 51% in controls in WTCCC samples
Age Group Adults : Mean age(SD)(year):42.2 (12.6) in cases and 42.2 (13.4) in controls in NIMH/Pritzker samples,in cases(47.1 (12.2) in complete sample,46.8 (12.3) in reduced sample) and 39.5 (16.3) in controls in GSK samples,40-49 in cases in WTCCC samples

Detail Info

SNPs reported by this study for BD (count: 23)