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Study Report
Comment on Study | View All Comments on Study |
Reference | Schosser, A.,2011 PMID: 21323636 |
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Citation | Schosser, A., M. Schloegelhofer, et al. (2011). "Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study." World J Biol Psychiatry 12(4): 309-315. |
Disease Type | Bipolar Disorder |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | 526 BPD cases and 691 controls |
SNP/Region/Marker Size | 51 SNPs |
Predominant Ethnicity | Caucasian |
Population | Brithsh and Austrian |
Gender | UK sample:34.63% men in BPD patients and 39.42% men in control;Austria sample:54.69% men in BPD patients and 35.34% men in control |
Age Group | Adults : Mean age(SD)(year):UK sample:48.01(11.26) in BPD patients and 31.78(12.45) in control;Austria sample:42.27(15.05) in BPD patients and 35.45(8.50) in control |
Sample Diagnosis | DSM and ICD10 |
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Sample Status | Our sample from UK was recruited in London and consists 463 patients with a diagnosis of BPD derived from the Bipolar Affective Disorder Case Control Study (BACCS). Subjects were excluded if they or a fi rst-degree relative have ever fulfi lled criteria for schizophrenia, if they experienced psychotic symptoms that were mood incongruent or present when there was no evidence for mood disturbance. Additional exclusion criteria included intravenous drug use with a lifetime diagnosis of drug dependency, or if manias occurred solely in relation to, or as a consequence of, alcohol or substance abuse/dependence and/or medical illness. A total of 449 control subjects from London/UK screened for lifetime absence of psychiatric disorder using a modifi ed version of the Past History Schedule (McGuffi n et al. 1986), were recruited. Potential control subjects were identifi ed among students and staff working at King ' s College London (internal mail) and via media advertisement (local newspapers). Sixty-four unrelated patients with a diagnosis of BPD disorder were recruited in Vienna, Austria. Hospitalized and outpatient individuals were identifi ed and interviewed face-to-face using the Schedule for Affective Disorders and Schizophrenia, Lifetime version (Spitzer and Endicott 1987) or Structured Clinical Interview for DSM Disorders (SCID-I, Wittchen et al. 1997) interview. In addition, an unstructured psychiatric interview and a family history evaluation were completed for each subject. A total of 243 control subjects from Vienna/Austria, without personal history of psychiatric disorders (past and present) as well as no psychiatric history in fi rst-degree relatives, were recruited. All participants from Austria were white European Caucasians. |
Technique | genotyping |
Statistical Method | A standard chi-square (X2) statistic was calculated to test for genotypic association with each SNP using PASWStatistics Version 18.0 for MAC. The computer program FINETTI (http://ihg.gsf.de/cgi-bin/hw/hwa1.pl) was used to calculate the Cochran -Armitage trend statistic to test for allelic association.All P values reported were two-tailed. We performed a Cochran - Mantel - Haenszel statistics using R version 2.8.1 (http://www.r-project.org/) to test for genotypic and/or allelic differences between the two samples. |
Result Summary | RESULTS: No genotypic and/or allelic association, as well as no haplotypic association, was found for any SNP after multiple testing correction. CONCLUSIONS: However, we cannot exclude the possibility that our sample might not have the power to detect rare variants associated with susceptibility to BPD. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|---|
rs9881504 | RNU2-11P LOC727978 | chi-square (X2) test: genotype, X2=5.743, P-value = 0.057; allele, X2=2.63, P-value = 0.105 | No significant association was observed. No significant association was observed. | Negative | ||
rs9880989 | IQCG | chi-square (X2) test: genotype, X2=0.066, P-value = 0.968; allele, X2=0, P-value = 0.96 | No significant association was observed. No significant association was observed. | Negative | ||
rs923066 | FBXO45 | chi-square (X2) test: genotype, X2=2.819, P-value = 0.244; allele, X2=2.81, P-value = 0.094 | No significant association was observed. No significant association was observed. | Negative | ||
rs891668 | BDH1 | chi-square (X2) test: genotype, X2=1.875, P-value = 0.392; allele, X2=1.57, P-value = 0.209 | No significant association was observed. No significant association was observed. | Negative | ||
rs9842842 | VEZF1P1 | chi-square (X2) test: genotype, X2=0.51, P-value = 0.775; allele, X2=0.5, P-value = 0.478 | No significant association was observed. No significant association was observed. | Negative | ||
rs9311 | WDR53 | chi-square (X2) test: genotype, X2=1.872, P-value = 0.392; allele, X2=0.09, P-value = 0.76 | No significant association was observed. No significant association was observed. | Negative | ||
rs7659 | APOD | chi-square (X2) test: genotype, X2=0.299, P-value = 0.861; allele, X2=0.29, P-value = 0.59 | No significant association was observed. No significant association was observed. | Negative | ||
rs7639752 | PCYT1A SLC51A | chi-square (X2) test: genotype, X2=4.894, P-value = 0.087; allele, X2=4.89, P-value = 0.027 | Significant association was found . Significant association was found . | Positive | ||
rs823512 | PPP1R2 | chi-square (X2) test: genotype, X2=5.74, P-value = 0.057; allele, X2=0.12, P-value = 0.727 | No significant association was observed. No significant association was observed. | Negative | ||
rs813153 | FAM43A | chi-square (X2) test: genotype, X2=0.508, P-value = 0.776; allele, X2=0, P-value = 0.959 | No significant association was observed. No significant association was observed. | Negative | ||
rs745497 | TNK2 | chi-square (X2) test: genotype, X2=2.386, P-value = 0.303; allele, X2=1.08, P-value = 0.299 | No significant association was observed. No significant association was observed. | Negative | ||
rs6788448 | ATP13A4 | chi-square (X2) test: genotype, X2=0.171, P-value = 0.918; allele, X2=0.13, P-value = 0.724 | No significant association was observed. No significant association was observed. | Negative | ||
rs7629772 | APOD | chi-square (X2) test: genotype, X2=1.793, P-value = 0.408; allele, X2=0.33, P-value = 0.563 | No significant association was observed. No significant association was observed. | Negative | ||
rs7624750 | OPA1 OPA1-AS1 MED12 | chi-square (X2) test: genotype, X2=2.421, P-value = 0.298; allele, X2=2.42, P-value = 0.12 | No significant association was observed. No significant association was observed. | Negative | ||
rs6778879 | TCTEX1D2 | chi-square (X2) test: genotype, X2=0.455, P-value = 0.797; allele, X2=0.28, P-value = 0.597 | No significant association was observed. No significant association was observed. | Negative | ||
rs6778889 | RNF168 SMCO1 | chi-square (X2) test: genotype, X2=0.527, P-value = 0.768; allele, X2=0.52, P-value = 0.471 | No significant association was observed. No significant association was observed. | Negative | ||
rs6780822 | MB21D2 | chi-square (X2) test: genotype, X2=5.573, P-value = 0.062; allele, X2=5.57, P-value = 0.018 | No significant association was observed. No significant association was observed. | Negative | ||
rs6785339 | TM4SF19 TM4SF19-AS1 | chi-square (X2) test: genotype, X2=2.54, P-value = 0.281; allele, X2=2.54, P-value = 0.111 | No significant association was observed. No significant association was observed. | Negative | ||
rs522174 | MFI2 RPSAP30 | chi-square (X2) test: genotype, X2=0.312, P-value = 0.855; allele, X2=0.1, P-value = 0.752 | No significant association was observed. No significant association was observed. | Negative | ||
rs6583248 | KIAA0226 | chi-square (X2) test: genotype, X2=1.628, P-value = 0.443; allele, X2=0.88, P-value = 0.347 | No significant association was observed. No significant association was observed. | Negative | ||
rs6605321 | LMLN | chi-square (X2) test: genotype, X2=0.247, P-value = 0.884; allele, X2=0.2, P-value = 0.652 | No significant association was observed. No significant association was observed. | Negative | ||
rs6734 | NCBP2 SENP5 NCBP2-AS1 | chi-square (X2) test: genotype, X2=0.651, P-value = 0.722; allele, X2=1.63, P-value = 0.201 | No significant association was observed. No significant association was observed. | Negative | ||
rs4677666 | XXYLT1 | chi-square (X2) test: genotype, X2=0.128, P-value = 0.938; allele, X2=0.05, P-value = 0.818 | No significant association was observed. No significant association was observed. | Negative | ||
rs4916598 | MFI2 | chi-square (X2) test: genotype, X2=0.047, P-value = 0.977; allele, X2=0.03, P-value = 0.852 | No significant association was observed. No significant association was observed. | Negative | ||
rs4927879 | LINC00885 | chi-square (X2) test: genotype, X2=7.029, P-value = 0.03; allele, X2=4.73, P-value = 0.03 | Significant association was found . Significant association was found . | Positive | ||
rs4974539 | CPN2 | chi-square (X2) test: genotype, X2=7.58, P-value = 0.023; allele, X2=0.62, P-value = 0.43 | Significant association was found . Significant association was found . | Positive | ||
rs3747672 | TNK2 | chi-square (X2) test: genotype, X2=2.58, P-value = 0.275; allele, X2=1.94, P-value = 0.164 | No significant association was observed. No significant association was observed. | Negative | ||
rs3774005 | CLDN16 | chi-square (X2) test: genotype, X2=3.231, P-value = 0.199; allele, X2=0.69, P-value = 0.407 | No significant association was observed. No significant association was observed. | Negative | ||
rs3817672 | TFRC RNU7-18P | chi-square (X2) test: genotype, X2=4.812, P-value = 0.09; allele, X2=2.83, P-value = 0.092 | No significant association was observed. No significant association was observed. | Negative | ||
rs4459932 | UBXN7 | chi-square (X2) test: genotype, X2=2.201, P-value = 0.333; allele, X2=0.8, P-value = 0.371 | No significant association was observed. No significant association was observed. | Negative | ||
rs338217 | DLG1 DLG1-AS1 | chi-square (X2) test: genotype, X2=1.535, P-value = 0.464; allele, X2=1.43, P-value = 0.232 | No significant association was observed. No significant association was observed. | Negative | ||
rs2885470 | FYTTD1 KIAA0226 | chi-square (X2) test: genotype, X2=2.698, P-value = 0.259; allele, X2=0.02, P-value = 0.893 | No significant association was observed. No significant association was observed. | Negative | ||
rs281817 | ATP13A4 ATP13A4-AS1 | chi-square (X2) test: genotype, X2=1.936, P-value = 0.38; allele, X2=1.83, P-value = 0.176 | No significant association was observed. No significant association was observed. | Negative | ||
rs2368048 | HES1 | chi-square (X2) test: genotype, X2=1.95, P-value = 0.377; allele, X2=0.97, P-value = 0.326 | No significant association was observed. No significant association was observed. | Negative | ||
rs2368041 | HES1 | chi-square (X2) test: genotype, X2=1.497, P-value = 0.473; allele, X2=1.21, P-value = 0.271 | No significant association was observed. No significant association was observed. | Negative | ||
rs2341399 | SMCO1 | chi-square (X2) test: genotype, X2=0.68, P-value = 0.712; allele, X2=0.1, P-value = 0.748 | No significant association was observed. No significant association was observed. | Negative | ||
rs2293378 | CCDC50 | chi-square (X2) test: genotype, X2=1.909, P-value = 0.385; allele, X2=0.08, P-value = 0.781 | No significant association was observed. No significant association was observed. | Negative | ||
rs225 | chi-square (X2) test: genotype, X2=6.83, P-value = 0.033; allele, X2=0.1, P-value = 0.749 | Significant association was found . Significant association was found . | Positive | |||
rs2050806 | ACAP2 | chi-square (X2) test: genotype, X2=0.078, P-value = 0.962; allele, X2=0.02, P-value = 0.9 | No significant association was observed. No significant association was observed. | Negative | ||
rs2043264 | chi-square (X2) test: genotype, X2=2.549, P-value = 0.28; allele, X2=1.14, P-value = 0.285 | No significant association was observed. No significant association was observed. | Negative | |||
rs1873405 | DPPA2P3 | chi-square (X2) test: genotype, X2=0.112, P-value = 0.946; allele, X2=0.1, P-value = 0.749 | No significant association was observed. No significant association was observed. | Negative | ||
rs1835669 | chi-square (X2) test: genotype, X2=0.174, P-value = 0.917; allele, X2=0.17, P-value = 0.678 | No significant association was observed. No significant association was observed. | Negative | |||
rs1705991 | LSG1 | chi-square (X2) test: genotype, X2=0.133, P-value = 0.936; allele, X2=0, P-value = 0.984 | No significant association was observed. No significant association was observed. | Negative | ||
rs1675955 | TMEM44 | chi-square (X2) test: genotype, X2=1.095, P-value = 0.578; allele, X2=0.03, P-value = 0.861 | No significant association was observed. No significant association was observed. | Negative | ||
rs1568565 | APOD | chi-square (X2) test: genotype, X2=4.72, P-value = 0.094; allele, X2=1.01, P-value = 0.314 | No significant association was observed. No significant association was observed. | Negative | ||
rs1522394 | ZDHHC19 PCYT1A SLC51A | chi-square (X2) test: genotype, X2=6.236, P-value = 0.044; allele, X2=3.62, P-value = 0.057 | No significant association was observed. No significant association was observed. | Negative | ||
rs11475 | PPP1R2 | chi-square (X2) test: genotype, X2=1.271, P-value = 0.53; allele, X2=0.01, P-value = 0.923 | No significant association was observed. No significant association was observed. | Negative | ||
rs13070515 | LRRC15 | chi-square (X2) test: genotype, X2=3.68, P-value = 0.159; allele, X2=0.01, P-value = 0.937 | No significant association was observed. No significant association was observed. | Negative | ||
rs10933671 | chi-square (X2) test: genotype, X2=1.767, P-value = 0.413; allele, X2=0.62, P-value = 0.431 | No significant association was observed. No significant association was observed. | Negative | |||
rs1134986 | DLG1 | chi-square (X2) test: genotype, X2=1.557, P-value = 0.459; allele, X2=0.61, P-value = 0.436 | No significant association was observed. No significant association was observed. | Negative |
Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
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rs6583248 - rs2885470 | KIAA0226 FYTTD1 | Haplotype analysis:individual P-value = 0.348, global P-value = 0.193 | No significant association was found . No significant association was found . | Negative | |
rs9880989 - rs6605321 | IQCG LMLN | Haplotype analysis:individual P-value = 0.775, global P-value = 0.436 | No significant association was found . No significant association was found . | Negative | |
rs823512 - rs11475 | A-C | PPP1R2 | Haplotype analysis:individual P-value = 0.035, global P-value = 0.056 | Significant association was found in individual P-value. Significant association was found in individual P-value. | Positive |
rs7639752 - rs6785339 | PCYT1A TM4SF19 | Haplotype analysis:individual P-value = 0.427, global P-value = 0.166 | No significant association was found . No significant association was found . | Negative | |
rs6785339 - rs4459932 | TM4SF19 UBXN7 | Haplotype analysis:individual P-value = 0.342, global P-value = 0.107 | No significant association was found . No significant association was found . | Negative | |
rs6778879 - rs6785339 | G-T | TCTEX1D2 TM4SF19 | Haplotype analysis:individual P-value = 0.012, global P-value = 0.011 | Significant association was found in both individual P-value...... Significant association was found in both individual P-value and global P-value. More... | Positive |
rs3747672 - rs9881504 | TNK2 | Haplotype analysis:individual P-value = 0.175, global P-value = 0.069 | No significant association was found . No significant association was found . | Negative | |
rs3747672 - rs745497 | TNK2 | Haplotype analysis:individual P-value = 0.116, global P-value = 0.211 | No significant association was found . No significant association was found . | Negative | |
rs4677666 - rs2050806 | ACAP2 | Haplotype analysis:individual P-value = 0.842, global P-value = 0.419 | No significant association was found . No significant association was found . | Negative | |
rs6788448 - rs281817 | ATP13A4 | Haplotype analysis:individual P-value = 0.261, global P-value = 0.118 | No significant association was found . No significant association was found . | Negative | |
rs1568565 - rs7629772 | APOD | Haplotype analysis:individual P-value = 0.941, global P-value = 0.587 | No significant association was found . No significant association was found . | Negative | |
rs6778889 - rs9311 | SMCO1 WDR53 | Haplotype analysis:individual P-value = 0.546, global P-value = 0.184 | No significant association was found . No significant association was found . | Negative | |
rs6778889 - rs2341399 | SMCO1 | Haplotype analysis:individual P-value = 0.413, global P-value = 0.157 | No significant association was found . No significant association was found . | Negative | |
rs1134986 - rs338217 | DLG1 | Haplotype analysis:individual P-value = 0.447, global P-value = 0.182 | No significant association was found . No significant association was found . | Negative | |
rs4974539 - rs13070515 | CPN2 LRRC15 | Haplotype analysis:individual P-value = 0.782, global P-value = 0.356 | No significant association was found . No significant association was found . | Negative | |
rs745497-rs9881504 | TNK2 | Haplotype analysis:individual P-value = 0.199, global P-value = 0.068 | No significant association was found . No significant association was found . | Negative | |
rs2341399 - rs9311 | WDR53 | Haplotype analysis:individual P-value = 0.977, global P-value = 0.688 | No significant association was found . No significant association was found . | Negative |
Variant Name | Related Gene | Type | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs2550240 | MUC4 | chi-square (X2) test: genotype, X2=2.75, P-value = 0.253; allele, X2=0.51, P-value = 0.473 | No significant association was observed. No significant association was observed. | Negative |
Gene | Statistical Values/Author Comments | Result Category |
---|---|---|
LSG1 | No significant association was observed. No significant association was observed. | Negative |
CLDN16 | No significant association was observed. No significant association was observed. | Negative |
TFRC | No significant association was observed. No significant association was observed. | Negative |
FYTTD1 | No significant association was observed. No significant association was observed. | Negative |
ACAP2 | No significant association was observed. No significant association was observed. | Negative |
ZDHHC19 | No significant association was observed. No significant association was observed. | Negative |
PPP1R2 | No significant association was observed. No significant association was observed. | Negative |
APOD | No significant association was observed. No significant association was observed. | Negative |
CPN2 | Significant association was found . Significant association was found . | Positive |
LMLN | No significant association was observed. No significant association was observed. | Negative |
CCDC50 | No significant association was observed. No significant association was observed. | Negative |
RPSAP30 | No significant association was observed. No significant association was observed. | Negative |
DPPA2P3 | No significant association was observed. No significant association was observed. | Negative |
LOC727978 | No significant association was observed. No significant association was observed. | Negative |
TCTEX1D2 | No significant association was observed. No significant association was observed. | Negative |
ATP13A4 | No significant association was observed. No significant association was observed. | Negative |
LRRC15 | No significant association was observed. No significant association was observed. | Negative |
SMCO1 | No significant association was observed. No significant association was observed. | Negative |
TM4SF19 | No significant association was observed. No significant association was observed. | Negative |
DLG1 | No significant association was observed. No significant association was observed. | Negative |
VEZF1P1 | No significant association was observed. No significant association was observed. | Negative |
FAM43A | No significant association was observed. No significant association was observed. | Negative |
MB21D2 | No significant association was observed. No significant association was observed. | Negative |
UBXN7 | No significant association was observed. No significant association was observed. | Negative |
TNK2 | No significant association was observed. No significant association was observed. | Negative |
NCBP2 | No significant association was observed. No significant association was observed. | Negative |
HES1 | No significant association was observed. No significant association was observed. | Negative |
XXYLT1 | No significant association was observed. No significant association was observed. | Negative |
MUC4 | No significant association was observed. No significant association was observed. | Negative |
OPA1 | No significant association was observed. No significant association was observed. | Negative |
WDR53 | No significant association was observed. No significant association was observed. | Negative |
BDH1 | No significant association was observed. No significant association was observed. | Negative |
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Last update: March 31, 2016