Gene Report

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Basic Info

Approved Symbol	CPN2
Previous Symbol	ACBP
Approved Name	carboxypeptidase N, polypeptide 2
Previous Name	carboxypeptidase N, polypeptide 2, 83kD
Location	3q29
Position	chr3:194339765-194351328, -1
External Links	HGNC: 2313 Entrez Gene: 1370 Ensembl: ENSG00000178772 UCSC: uc003fts.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs4974539 Haplotype: rs4974539 - rs13070515()	Significant association was found .	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	NAS[2378615]	97
GO:0030234	enzyme regulator activity	molecular function	NAS[2378615]	3
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0050790	regulation of catalytic activity	biological process	NAS[2378615]	11
GO:0050821	protein stabilization	biological process	NAS[2378615]	12
GO:0072562	blood microparticle	cellular component	IDA[22516433]	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CPN2	CPN1	NO	in vitro	14687935

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4974539	chr3:194341178 - 194341178(1)	stop_gained	1(1/0/0)

rs_ID	Location	Functional Annotation
rs6792027	chr3:194351840 - 194351840(1)	downstream_gene_variant; upstream_gene_variant
rs8513	chr3:194355482 - 194355482(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs3732474	chr3:194342424 - 194342424(1)	synonymous_variant
rs6774653	chr3:194340832 - 194340832(1)	3_prime_UTR_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:194339765..194351328 View in gBrowse