BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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KEGG Pathway Report

Basic Info

ID	hsa04070
Name	Phosphatidylinositol signaling system
No. of Genes in BDgene	16
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
Phosphatidylinositol signaling system	PBA paper	Chen, L., 2009	WTCCC	Prioritizing Risk Pathways fusing SNPs and pathways (PRP)	risk score=0.95
Phosphatidylinositol signaling system	PBA paper	Chang, S., 2015	group A	i-GSEA4GWAS v2,SRT	FDR=0.201 (A) by i-GSEA4GWAS v2; FDR=0.043 (A) by SRT

Pathway related genes in BDgene (count: 16)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
IMPA1	inositol(myo)-1(or 4)-monophosphatase 1	8q21.1-q21.3	1(0/1/0)
PLCG1	phospholipase C, gamma 1	20q12-q13.1	1(0/1/0)
INPP1	inositol polyphosphate-1-phosphatase	2q32	1(0/1/0)
DGKH	diacylglycerol kinase, eta	13q13.3	6(3/3/0)
DGKQ	diacylglycerol kinase, theta 110kDa	4p16.3	1(0/0/1)
PIK3C3	phosphatidylinositol 3-kinase, catalytic subunit type 3	18q12.3	1(1/0/0)
PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11p15.5-p14	1(0/1/0)
PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	7q22	1(0/0/1)
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	16q24.1	1(0/1/0)
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	18p11.2	4(2/2/0)
INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	2q11.2	1(0/0/1)
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5q13.1	1(1/0/0)
SYNJ1	synaptojanin 1	21q22.2	2(0/2/0)
PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha	22q11.21	3(1/2/0)
DGKB	diacylglycerol kinase, beta 90kDa	7p21.2	1(1/0/0)
PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	10p12.2	4(1/3/0)