BDgene

KEGG Pathway Report

Basic Info
ID hsa04070
Name Phosphatidylinositol signaling system
No. of Genes in BDgene  16
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
Phosphatidylinositol signaling system PBA paper Chen, L., 2009 WTCCC Prioritizing Risk Pathways fusing SNPs and pathways (PRP) risk score=0.95
Phosphatidylinositol signaling system PBA paper Chang, S., 2015 group A i-GSEA4GWAS v2,SRT FDR=0.201 (A) by i-GSEA4GWAS v2; FDR=0.043 (A) by SRT

Pathway related genes in BDgene (count: 16)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 8q21.1-q21.3 1(0/1/0)
PLCG1 phospholipase C, gamma 1 20q12-q13.1 1(0/1/0)
INPP1 inositol polyphosphate-1-phosphatase 2q32 1(0/1/0)
DGKH diacylglycerol kinase, eta 13q13.3 6(3/3/0)
DGKQ diacylglycerol kinase, theta 110kDa 4p16.3 1(0/0/1)
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 18q12.3 1(1/0/0)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 11p15.5-p14 1(0/1/0)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 7q22 1(0/0/1)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 1(0/1/0)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 18p11.2 4(2/2/0)
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2q11.2 1(0/0/1)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 1(1/0/0)
SYNJ1 synaptojanin 1 21q22.2 2(0/2/0)
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 22q11.21 3(1/2/0)
DGKB diacylglycerol kinase, beta 90kDa 7p21.2 1(1/0/0)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 10p12.2 4(1/3/0)