KEGG Pathway Report

Basic Info
ID hsa04530
Name Tight junction
No. of Genes in BDgene  18
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
Tight junction PBA paper O'Dushlaine, C.,2011 WTCCC SNP ratio test P-value=0.02; CAM and tight junction overlap at a molecular level and are involved in the same functions
Tight junction PBA paper Chen, L., 2009 WTCCC Prioritizing Risk Pathways fusing SNPs and pathways (PRP) risk score=0.51

Pathway related genes in BDgene (count: 18)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
EXOC4 exocyst complex component 4 7q31 1(0/0/1)
MYH14 myosin, heavy chain 14, non-muscle 19q13.33 1(0/1/0)
PRKCZ protein kinase C, zeta 1p36.33-p36.2 1(1/0/0)
CSNK2A1 casein kinase 2, alpha 1 polypeptide 20p13 2(0/2/0)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 18p11.2 1(1/0/0)
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 3p14.1 1(1/0/0)
EXOC3 exocyst complex component 3 5p15.33 1(1/0/0)
PARD6B par-6 family cell polarity regulator beta 20q13.13 1(0/0/1)
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0)
CTTN cortactin 11q13 1(1/0/0)
CTNNA3 catenin (cadherin-associated protein), alpha 3 10q21 1(1/0/0)
PRKCE protein kinase C, epsilon 2p21 1(0/1/0)
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 4p16.1 2(1/1/0)
JAM3 junctional adhesion molecule 3 11q25 2(1/1/0)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3p21.31 1(0/1/0)
CLDN16 claudin 16 3q28 1(0/1/0)
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 8p21.2 1(0/1/0)
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 7q21 1(1/0/0)