BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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KEGG Pathway Report

Basic Info

ID	hsa04720
Name	Long-term potentiation
No. of Genes in BDgene	13
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
Long-term potentiation	i-GSEA analysis	Smith, E. N., Mol Psychiatry, 2009	dbGaP GAIN EA	i-GSEA by using i-GSEA4GWAS	P-value< 0.001, FDR=0.044969697	Link in i-GSEA4GWAS
Long-term potentiation	PBA paper	Chang, S., 2015	group B	i-GSEA4GWAS v2, GenGen	FDR=0.0482 (B) by i-GSEA4GWAS v2; FDR=0.003 (B) by GenGen

Pathway related genes in BDgene (count: 13)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GRIA1	glutamate receptor, ionotropic, AMPA 1	5q33	2(2/0/0)
CREBBP	CREB binding protein	16p13.3	1(0/1/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	16p13.2	1(1/0/0)
PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	8p21.3	1(0/1/0)
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	9q34.3	3(2/1/0)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	12p13.1	8(4/4/0)
ATF4	activating transcription factor 4	22q13.1	1(1/0/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	20(17/3/0)
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	19q13.33	1(1/0/0)
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	10q22.2	2(1/1/0)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	5q32	2(1/1/0)
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1p36.1	1(0/1/0)