Study Report
Basic Info
| Reference |
de Mooij-van Malsen, A. J.,2009 PMID: 19691954
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| Citation |
de Mooij-van Malsen, A. J., H. A. van Lith, et al. (2009). "Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder." Biol Psychiatry 66(12): 1123-1130.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
1868 BPD cases versus 14,311 control subjects |
| SNP/Region/Marker Size |
391 SNPs |
| Predominant Ethnicity |
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| Population |
WTCCC collection |
Detail Info
| Statistical Method |
P-values of all SNPs within the Affymetrix 500k Gene chip (6) located within the selected candidate genes were examined (total of 391 SNPs within the 9 selected genes) using additive/genetic models with or without sex-stratification. |
| Result Summary |
After this correction the association between the ADCY8(rs3914071) and BPD remained significant (P-value=0.0055; genetic model,without sex-stratification). In addition, within the basic control dataset, a significant association was found for KCNQ3 (rs1437812;P-value=0.0029; additive model, without sex-stratification). |
Genes reported by this study for BD (count: 2)
| Gene |
Statistical Values/Author Comments |
Result Category |
| ADCY8 |
After this correction the association between the ADCY8(rs3914071) and BPD remained significant (P-v......
After this correction the association between the ADCY8(rs3914071) and BPD remained significant (P-value = 0.0055; genetic model, without sex-stratification).
More...
|
Positive
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| KCNQ3 |
Within the basic control dataset, a significant association was found for KCNQ3 (rs1437812; P-value ......
Within the basic control dataset, a significant association was found for KCNQ3 (rs1437812; P-value = 0.0029; additive model, without sex-stratification).
More...
|
Positive
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