SNP Report

Basic Info

Name	rs3750889 dbSNP Ensembl
Location	chr8:130990088 - 130990088(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.226637
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000286355, ENST00000377928, ENST00000522949)
No. of Studies	2 (Positive: 1; Negative: 0; Trend: 1)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Zandi, P. P., 2008 (b)	A/G	G	FBAT allelic P-value = 3.40E-04 ; Geno-PDT genotypic P-valu...... FBAT allelic P-value = 3.40E-04 ; Geno-PDT genotypic P-value = 2.63E-02 More...	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
Zhang, P.,2010			Association analysis: FBAT P-value = 0.0005 Association analysis: FBAT P-value = 0.0005	Suggestive association was found. Suggestive association was found.	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)

SNPs in LD with rs3750889 (count: 2) View in gBrowse (chr8:130974978..131000624 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs6415528		intron_variant	0.829[CEU]
rs6470879		intron_variant	0.853[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)