BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Region Report

Basic Info

Region Name	8q24
Chromosome Position	chr8:116700000-145138636
No. of Studies (Positive/Negative/Trend)	7(2/2/3)

Region related studies (count: 7)

Reference	Markers	Statistical Values	Author Comments	Result Category
Avramopoulos, D.,2004	D8S1835, D8S378, HC83REP, D8S1708, D8S1462, D8S1710, D8S554, D8S1466, D8S1111, D8S1100, D8S272, D8S523, D8S256, D8S1782, D8S284, D8S1765, D8S557, D8S558, D8S1740, D8S529, D8S1796, D8S1746, D8S274	Linkage analysis: for Narrow phenotypic model (BPI, BPII, SA...... Linkage analysis: for Narrow phenotypic model (BPI, BPII, SAM), NPL = 3.25, two-point LOD = 3.32, HLOD = 2.39; for Broad phenotypic model (BPI, BPII, SAM, RUP), NPL = 2.64, two-point LOD = 1.93, HLOD = 1.45 More...	The LOD score for D8S256 was 3.32, which exceeds the thresho...... The LOD score for D8S256 was 3.32, which exceeds the threshold for genomewide significance (3.3 for parametric analysis). More...	Positive
Badenhop, R. F.,2002	D8S514	Two-point LOD score analysis: HLOD = 2.08, theta = 0, Model:...... Two-point LOD score analysis: HLOD = 2.08, theta = 0, Model: 0.9 dominant BPI, SZ/MA More...	Suggestive linkage was found in this region(HLOD > 1.5). Suggestive linkage was found in this region(HLOD > 1.5).	Trend
Cichon, S.,2001(b)	D8S514	Linkage analysis: two-point LOD = 3.62 Linkage analysis: two-point LOD = 3.62	Significant linkage was found in this region. Significant linkage was found in this region.	Positive
Greenwood, T. A.,2012	D8S592	Linkage analysis: for BD+MDD, LOD = 1.17 Linkage analysis: for BD+MDD, LOD = 1.17	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
McInnis, M. G.,2003(b)	D8S256	Linkage analysis: Model BP, NPL = 3.13, P-value = 0.003, LOD...... Linkage analysis: Model BP, NPL = 3.13, P-value = 0.003, LOD(ASM) = 2.1 More...	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Jones, I.,2007	D8S284	linkage analysis: Max LOD score = 2.03 linkage analysis: Max LOD score = 2.03	There is a trend for Significant linkage. There is a trend for Significant linkage.	Trend
Cheng, R.,2006	D8S1179	Two point parametric linkage analysis: LOD = 0.33, theta = 0...... Two point parametric linkage analysis: LOD = 0.33, theta = 0.1, Model BP3, dom More...	No significant linkage was found in this region. No significant linkage was found in this region.	Negative

Region related genes (count: 15)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
FAM84B	family with sequence similarity 84, member B	8q24.13	2(1/1/0)
FAM49B	family with sequence similarity 49, member B	8q24.21	1(0/1/0)
TRIB1	tribbles pseudokinase 1	8q24.13	1(0/0/1)
FER1L6	fer-1-like family member 6	8q24.13	1(0/1/0)
ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	8q24.22	4(3/0/1)
SLC30A8	solute carrier family 30 (zinc transporter), member 8	8q24.11	1(1/0/0)
PCAT1	prostate cancer associated transcript 1 (non-protein coding)	8q24.21	1(0/1/0)
OC90	otoconin 90	8q24.22	1(0/1/0)
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	8q24.1-q24.2	1(0/1/0)
PVT1	Pvt1 oncogene (non-protein coding)	8q24	1(0/1/0)
ZHX2	zinc fingers and homeoboxes 2	8q24.13	1(0/0/1)
CCAT1	colon cancer associated transcript 1 (non-protein coding)	8q24.21	1(0/1/0)
LINC00977	long intergenic non-protein coding RNA 977	8q24.21	1(0/1/0)
KCNQ3	potassium channel, voltage gated KQT-like subfamily Q, member 3	8q24	4(3/0/1)

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Region: chr8:116700000..145138636 View in gBrowse