Study Report
Basic Info
| Reference |
Zhang, P.,2010 PMID: 21176025
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| Citation |
Zhang, P., N. Xiang, et al. (2010). "Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs." Bipolar Disord 12(8): 786-792.
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| Disease Type |
Bipolar Disorder |
| Study Design |
family-based |
| Study Type |
Candidate-gene association study |
| Sample Size |
Our sample comprised 3,525 genotyped individuals, including 1,391 males and 2,134 females from 737 families |
| SNP/Region/Marker Size |
22,725 SNPs |
| Predominant Ethnicity |
|
| Population |
NIMH collections |
Detail Info
| Statistical Method |
We performed single-marker association tests with the LAMP program, a maximum-likelihood method that jointly models linkage and association, to incorporate the large family sizes in our dataset (maximum family size: n = 23). |
| Result Summary |
RESULTS: Our association analysis identified the most significant marker (p=4.80 x 10(-5) ), near the gene encoding potassium voltage-gated channel KQT-like protein (KCNQ3). Other marginally significant markers were located near adenylate cyclase 8 (ADCY8) and ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1). CONCLUSIONS: We developed an approach to apply MACH imputation to family-based data, which can increase the power to detect association signals. Our association results showed suggestive evidence of association of BP with loci near KCNQ3, ADCY8, and ST3GAL1. Consistent with genes identified by genome-wide association studies for BP, our results suggest the involvement of ion channelopathy in BP pathogenesis. However, common variants are insufficient to explain linkage findings in 8q24; other genetic variation should be explored. |
SNPs reported by this study for BD (count: 10)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs10094837 |
|
|
|
Association analysis: FBAT P-value = 0.0028
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs10095649 |
|
|
|
Association analysis: FBAT P-value = 0.0026
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs1023096 |
ADCY8
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|
|
Association analysis: FBAT P-value = 0.0007
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs17602731 |
KCNQ3
|
|
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Association analysis: FBAT P-value = 0.0032
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Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs2673582 |
KCNQ3
|
|
|
Association analysis: FBAT P-value = 0.000048
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Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs3750889 |
ADCY8
|
|
|
Association analysis: FBAT P-value = 0.0005
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs4523235 |
|
|
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Association analysis: FBAT P-value = 0.0027
|
Suggestive association was found.
Suggestive association was found.
|
Trend
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| rs4871780 |
|
|
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Association analysis: FBAT P-value = 0.00012
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs6984550 |
KCNQ3
|
|
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Association analysis: FBAT P-value = 0.0012
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs6986303 |
ST3GAL1
|
|
|
Association analysis: FBAT P-value = 0.0011
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Genes reported by this study for BD (count: 3)
| Gene |
Statistical Values/Author Comments |
Result Category |
| ADCY8 |
Our association results showed suggestive evidence of association of BP with loci near ADCY8.
Our association results showed suggestive evidence of association of BP with loci near ADCY8.
|
Trend
|
| ST3GAL1 |
Our association results showed suggestive evidence of association of BP with loci near ST3GAL1.
Our association results showed suggestive evidence of association of BP with loci near ST3GAL1.
|
Trend
|
| KCNQ3 |
Our association results showed suggestive evidence of association of BP with loci near KCNQ3.
Our association results showed suggestive evidence of association of BP with loci near KCNQ3.
|
Trend
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