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KEGG Pathway Report
Basic Info
| ID | hsa04510 |
|---|---|
| Name | Focal adhesion |
| No. of Genes in BDgene | 22 |
| Source | Pathway by PBA |
PBA Result
| Pathway Name in Paper | Source | Reference | Data Set | Tool | Result Parameters | Result Link |
|---|---|---|---|---|---|---|
| Focal adhesion | PBA paper | Chen, L., 2009 | WTCCC | Prioritizing Risk Pathways fusing SNPs and pathways (PRP) | risk score=0.58 | |
| Focal adhesion | PBA paper | Peng, G., 2010 | WTCCC | hypergeometric test (Fisher's exact test), Sidak's method, Simes' method, Simes/FDR method | Fisher exact test P-value=0.0116289 |
Pathway related genes in BDgene (count: 22)
| Approved Symbol | Approved Name | Location | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| DIAPH1 | diaphanous-related formin 1 | 5q31 | 1(1/0/0) |
| EGFR | epidermal growth factor receptor | 7p12 | 1(0/0/1) |
| MAPK10 | mitogen-activated protein kinase 10 | 4q22-q23 | 1(0/1/0) |
| ITGA9 | integrin, alpha 9 | 3p21.3 | 1(1/0/0) |
| VCL | vinculin | 10q22.1-q23 | 1(0/0/1) |
| PARVG | parvin, gamma | 22q13.31 | 1(1/0/0) |
| LAMA3 | laminin, alpha 3 | 18q11.2 | 1(0/0/1) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 8(0/8/0) |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 7p22 | 1(1/0/0) |
| PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | 7q22 | 1(0/0/1) |
| ITGB6 | integrin, beta 6 | 2q24.2 | 1(1/0/0) |
| PARVB | parvin, beta | 22q13.2-q13.33 | 1(1/0/0) |
| TNR | tenascin R | 1q24 | 2(0/2/0) |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 14q32.33 | 3(3/0/0) |
| COL11A2 | collagen, type XI, alpha 2 | 6p21.3 | 1(1/0/0) |
| BCL2 | B-cell CLL/lymphoma 2 | 18q21.3 | 2(0/2/0) |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | 1(1/0/0) |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 12q23.2 | 1(1/0/0) |
| RELN | reelin | 7q22 | 3(1/2/0) |
| LAMB1 | laminin, beta 1 | 7q22 | 1(0/0/1) |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 6q21 | 1(1/0/0) |
| ITGB8 | integrin, beta 8 | 7p15.3 | 1(1/0/0) |