BDgene

Enriched Pathway by Core Genes

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The pathway enrichment analysis for core genes was done by DAVID. The core genes for pathway enrichment analysis included both training genes and prioritized genes from gene prioritization analysis. Gene List

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Top e.g. 10, P-value < e.g. 1.0E-3, Total Gene Count < e.g. 350, Is PBA result? YES

Enriched Pathways (count: 51)

Category ID Name Mapped Gene Count Total Gene Count P-value Benjamini FDR Genes PBA Result?
1 GOTERM_BP_FAT GO:0007399 nervous system development 22 2224 1.27E-8 3.42E-7 2.26E-5 22 genes YES
2 GOTERM_MF_FAT GO:0004871 signal transducer activity 24 1762 4.82E-12 2.37E-10 6.57E-9 24 genes YES
3 GOTERM_MF_FAT GO:0004872 receptor activity 24 1680 1.77E-12 1.53E-10 2.42E-9 24 genes YES
4 GOTERM_CC_FAT GO:0005887 integral component of plasma membrane 23 1637 6.82E-11 1.19E-9 8.83E-8 23 genes YES
5 GOTERM_BP_FAT GO:0006811 ion transport 22 1475 5.96E-12 4.26E-10 1.05E-8 22 genes YES
6 GOTERM_MF_FAT GO:0005102 receptor binding 12 1464 0.001172682 0.0095921 1.588607405 12 genes YES
7 GOTERM_BP_FAT GO:0006812 cation transport 17 988 8.08E-10 3.2E-8 1.43E-6 17 genes YES
8 GOTERM_BP_FAT GO:0007417 central nervous system development 14 942 3.08E-7 5.28E-6 5.45E-4 14 genes YES
9 GOTERM_BP_FAT GO:0031175 neuron projection development 11 851 3.81E-5 3.2E-4 0.06742713 11 genes YES
10 GOTERM_BP_FAT GO:0030001 metal ion transport 17 828 5.98E-11 3.2E-9 1.06E-7 17 genes YES
11 GOTERM_CC_FAT GO:0045202 synapse 28 768 1.01E-24 2.47E-22 1.31E-21 28 genes YES
12 GOTERM_BP_FAT GO:0000904 cell morphogenesis involved in differentiation 10 763 9.7E-5 7.32E-4 0.171499021 10 genes YES
13 GOTERM_BP_FAT GO:0007420 brain development 12 717 1.1E-6 1.55E-5 0.001950693 12 genes YES
14 GOTERM_MF_FAT GO:0004672 protein kinase activity 6 653 0.028488647 0.136392409 32.59462048 6 genes YES
15 GOTERM_BP_FAT GO:0006954 inflammatory response 7 648 0.005395144 0.02577694 9.130517593 7 genes YES
16 GOTERM_BP_FAT GO:0007268 chemical synaptic transmission 26 620 1.6E-25 4.13E-22 2.84E-22 26 genes YES
17 GOTERM_MF_FAT GO:0008324 cation transmembrane transporter activity 8 614 0.001055867 0.008850036 1.431415794 8 genes YES
18 GOTERM_BP_FAT GO:0015672 monovalent inorganic cation transport 8 490 2.02E-4 0.001405267 0.357266676 8 genes YES
19 GOTERM_MF_FAT GO:0022838 substrate-specific channel activity 9 442 1.77E-5 2.26E-4 0.024186209 9 genes YES
20 GOTERM_MF_FAT GO:0005216 ion channel activity 9 426 1.36E-5 2.04E-4 0.018528758 9 genes YES
21 GOTERM_MF_FAT GO:0046873 metal ion transmembrane transporter activity 6 421 0.004931426 0.033535793 6.524262892 6 genes YES
22 GOTERM_BP_FAT GO:0006816 calcium ion transport 13 379 9.72E-11 4.9E-9 1.72E-7 13 genes YES
23 GOTERM_MF_FAT GO:0022836 gated channel activity 9 332 2.17E-6 3.95E-5 0.002966117 9 genes YES
24 GOTERM_CC_FAT GO:0043235 receptor complex 13 329 9.12E-11 1.48E-9 1.18E-7 13 genes YES
25 GOTERM_BP_FAT GO:0006869 lipid transport 4 317 0.045481159 0.156033678 56.12567291 4 genes YES
26 GOTERM_MF_FAT GO:0005085 guanyl-nucleotide exchange factor activity 8 307 1.45E-5 2.0E-4 0.019796314 8 genes YES
27 GOTERM_MF_FAT GO:0005261 cation channel activity 6 303 0.001186512 0.009480121 1.607202135 6 genes YES
28 KEGG_PATHWAY hsa04010 MAPK signaling pathway 5 255 0.050086706 0.231326508 44.93996299 5 genes YES
29 GOTERM_BP_FAT GO:0006813 potassium ion transport 5 221 0.002276923 0.012144819 3.954168213 5 genes YES
30 GOTERM_CC_FAT GO:0045211 postsynaptic membrane 14 211 1.59E-14 3.87E-13 2.06E-11 14 genes YES
31 GOTERM_BP_FAT GO:0007565 female pregnancy 5 205 0.001731742 0.009463748 3.021053466 5 genes YES
32 GOTERM_MF_FAT GO:0005244 voltage-gated ion channel activity 3 191 0.091350032 0.319069633 72.94693154 3 genes YES
33 GOTERM_MF_FAT GO:0022832 voltage-gated channel activity 3 191 0.091350032 0.319069633 72.94693154 3 genes YES
34 GOTERM_MF_FAT GO:0005516 calmodulin binding 5 189 0.001550106 0.012089995 2.094899472 5 genes YES
35 KEGG_PATHWAY hsa04020 Calcium signaling pathway 13 179 9.51E-11 3.04E-9 1.1E-7 13 genes YES
36 GOTERM_BP_FAT GO:0007586 digestion 3 167 0.066316913 0.210997744 70.31292206 3 genes YES
37 GOTERM_MF_FAT GO:0016247 channel regulator activity 5 135 4.42E-4 0.004002625 0.601070764 5 genes YES
38 GOTERM_MF_FAT GO:0022843 voltage-gated cation channel activity 3 135 0.049917455 0.209863435 50.28388405 3 genes YES
39 GOTERM_MF_FAT GO:0015085 calcium ion transmembrane transporter activity 4 128 0.004723773 0.032788435 6.257693419 4 genes YES
40 KEGG_PATHWAY hsa04722 Neurotrophin signaling pathway 4 120 0.027715802 0.15086102 27.8496063 4 genes YES
41 GOTERM_MF_FAT GO:0005262 calcium channel activity 4 113 0.003330148 0.024188161 4.450346946 4 genes YES
42 KEGG_PATHWAY hsa04540 Gap junction 5 88 0.001302753 0.011062431 1.502514733 5 genes YES
43 KEGG_PATHWAY hsa04720 Long-term potentiation 6 66 2.68E-5 3.43E-4 0.031146966 6 genes YES
44 GOTERM_MF_FAT GO:0004714 transmembrane receptor protein tyrosine kinase activity 3 65 0.01289272 0.069662851 16.23022239 3 genes YES
45 KEGG_PATHWAY hsa05214 Glioma 3 65 0.049309583 0.236383531 44.41456888 3 genes YES
46 GOTERM_BP_FAT GO:0007194 negative regulation of adenylate cyclase activity 5 24 3.58E-7 5.98E-6 6.34E-4 5 genes YES
47 GOTERM_MF_FAT GO:0005234 extracellular-glutamate-gated ion channel activity 4 20 1.92E-5 2.37E-4 0.026256726 4 genes YES
48 GOTERM_MF_FAT GO:0004970 ionotropic glutamate receptor activity 4 19 1.64E-5 2.17E-4 0.022359883 4 genes YES
49 GOTERM_MF_FAT GO:0004935 adrenergic receptor activity 3 16 8.07E-4 0.006943128 1.096403612 3 genes YES
50 GOTERM_MF_FAT GO:0004716 receptor signaling protein tyrosine kinase activity 2 10 0.026265383 0.128077738 30.45869048 2 genes YES
51 GOTERM_MF_FAT GO:0004952 dopamine neurotransmitter receptor activity 4 7 6.05E-7 1.49E-5 8.26E-4 4 genes YES

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016