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Enriched Pathway by Core Genes
The pathway enrichment analysis for core genes was done by DAVID. The core genes for pathway enrichment analysis included both training genes and prioritized genes from gene prioritization analysis. Gene List
Filter Enriched Pathway
Enriched Pathways (count: 51)
Category
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ID
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Name
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Mapped Gene Count
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Total Gene Count
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P-value
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Benjamini
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FDR
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Genes
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PBA Result?
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---|---|---|---|---|---|---|---|---|---|---|
1 | GOTERM_CC_FAT | GO:0045202 | synapse | 28 | 768 | 1.01E-24 | 2.47E-22 | 1.31E-21 |
28 genes
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YES |
2 | GOTERM_BP_FAT | GO:0007268 | chemical synaptic transmission | 26 | 620 | 1.6E-25 | 4.13E-22 | 2.84E-22 |
26 genes
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YES |
3 | GOTERM_MF_FAT | GO:0004872 | receptor activity | 24 | 1680 | 1.77E-12 | 1.53E-10 | 2.42E-9 |
24 genes
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YES |
4 | GOTERM_MF_FAT | GO:0004871 | signal transducer activity | 24 | 1762 | 4.82E-12 | 2.37E-10 | 6.57E-9 |
24 genes
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YES |
5 | GOTERM_CC_FAT | GO:0005887 | integral component of plasma membrane | 23 | 1637 | 6.82E-11 | 1.19E-9 | 8.83E-8 |
23 genes
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YES |
6 | GOTERM_BP_FAT | GO:0006811 | ion transport | 22 | 1475 | 5.96E-12 | 4.26E-10 | 1.05E-8 |
22 genes
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YES |
7 | GOTERM_BP_FAT | GO:0007399 | nervous system development | 22 | 2224 | 1.27E-8 | 3.42E-7 | 2.26E-5 |
22 genes
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YES |
8 | GOTERM_BP_FAT | GO:0030001 | metal ion transport | 17 | 828 | 5.98E-11 | 3.2E-9 | 1.06E-7 |
17 genes
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YES |
9 | GOTERM_BP_FAT | GO:0006812 | cation transport | 17 | 988 | 8.08E-10 | 3.2E-8 | 1.43E-6 |
17 genes
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YES |
10 | GOTERM_CC_FAT | GO:0045211 | postsynaptic membrane | 14 | 211 | 1.59E-14 | 3.87E-13 | 2.06E-11 |
14 genes
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YES |
11 | GOTERM_BP_FAT | GO:0007417 | central nervous system development | 14 | 942 | 3.08E-7 | 5.28E-6 | 5.45E-4 |
14 genes
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YES |
12 | GOTERM_CC_FAT | GO:0043235 | receptor complex | 13 | 329 | 9.12E-11 | 1.48E-9 | 1.18E-7 |
13 genes
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YES |
13 | KEGG_PATHWAY | hsa04020 | Calcium signaling pathway | 13 | 179 | 9.51E-11 | 3.04E-9 | 1.1E-7 |
13 genes
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YES |
14 | GOTERM_BP_FAT | GO:0006816 | calcium ion transport | 13 | 379 | 9.72E-11 | 4.9E-9 | 1.72E-7 |
13 genes
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YES |
15 | GOTERM_BP_FAT | GO:0007420 | brain development | 12 | 717 | 1.1E-6 | 1.55E-5 | 0.001950693 |
12 genes
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YES |
16 | GOTERM_MF_FAT | GO:0005102 | receptor binding | 12 | 1464 | 0.001172682 | 0.0095921 | 1.588607405 |
12 genes
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YES |
17 | GOTERM_BP_FAT | GO:0031175 | neuron projection development | 11 | 851 | 3.81E-5 | 3.2E-4 | 0.06742713 |
11 genes
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YES |
18 | GOTERM_BP_FAT | GO:0000904 | cell morphogenesis involved in differentiation | 10 | 763 | 9.7E-5 | 7.32E-4 | 0.171499021 |
10 genes
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YES |
19 | GOTERM_MF_FAT | GO:0022836 | gated channel activity | 9 | 332 | 2.17E-6 | 3.95E-5 | 0.002966117 |
9 genes
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YES |
20 | GOTERM_MF_FAT | GO:0005216 | ion channel activity | 9 | 426 | 1.36E-5 | 2.04E-4 | 0.018528758 |
9 genes
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YES |
21 | GOTERM_MF_FAT | GO:0022838 | substrate-specific channel activity | 9 | 442 | 1.77E-5 | 2.26E-4 | 0.024186209 |
9 genes
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YES |
22 | GOTERM_MF_FAT | GO:0005085 | guanyl-nucleotide exchange factor activity | 8 | 307 | 1.45E-5 | 2.0E-4 | 0.019796314 |
8 genes
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YES |
23 | GOTERM_BP_FAT | GO:0015672 | monovalent inorganic cation transport | 8 | 490 | 2.02E-4 | 0.001405267 | 0.357266676 |
8 genes
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YES |
24 | GOTERM_MF_FAT | GO:0008324 | cation transmembrane transporter activity | 8 | 614 | 0.001055867 | 0.008850036 | 1.431415794 |
8 genes
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YES |
25 | GOTERM_BP_FAT | GO:0006954 | inflammatory response | 7 | 648 | 0.005395144 | 0.02577694 | 9.130517593 |
7 genes
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YES |
26 | KEGG_PATHWAY | hsa04720 | Long-term potentiation | 6 | 66 | 2.68E-5 | 3.43E-4 | 0.031146966 |
6 genes
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YES |
27 | GOTERM_MF_FAT | GO:0005261 | cation channel activity | 6 | 303 | 0.001186512 | 0.009480121 | 1.607202135 |
6 genes
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YES |
28 | GOTERM_MF_FAT | GO:0046873 | metal ion transmembrane transporter activity | 6 | 421 | 0.004931426 | 0.033535793 | 6.524262892 |
6 genes
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YES |
29 | GOTERM_MF_FAT | GO:0004672 | protein kinase activity | 6 | 653 | 0.028488647 | 0.136392409 | 32.59462048 |
6 genes
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YES |
30 | GOTERM_BP_FAT | GO:0007194 | negative regulation of adenylate cyclase activity | 5 | 24 | 3.58E-7 | 5.98E-6 | 6.34E-4 |
5 genes
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YES |
31 | GOTERM_MF_FAT | GO:0016247 | channel regulator activity | 5 | 135 | 4.42E-4 | 0.004002625 | 0.601070764 |
5 genes
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YES |
32 | KEGG_PATHWAY | hsa04540 | Gap junction | 5 | 88 | 0.001302753 | 0.011062431 | 1.502514733 |
5 genes
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YES |
33 | GOTERM_MF_FAT | GO:0005516 | calmodulin binding | 5 | 189 | 0.001550106 | 0.012089995 | 2.094899472 |
5 genes
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YES |
34 | GOTERM_BP_FAT | GO:0007565 | female pregnancy | 5 | 205 | 0.001731742 | 0.009463748 | 3.021053466 |
5 genes
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YES |
35 | GOTERM_BP_FAT | GO:0006813 | potassium ion transport | 5 | 221 | 0.002276923 | 0.012144819 | 3.954168213 |
5 genes
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YES |
36 | KEGG_PATHWAY | hsa04010 | MAPK signaling pathway | 5 | 255 | 0.050086706 | 0.231326508 | 44.93996299 |
5 genes
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YES |
37 | GOTERM_MF_FAT | GO:0004952 | dopamine neurotransmitter receptor activity | 4 | 7 | 6.05E-7 | 1.49E-5 | 8.26E-4 |
4 genes
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YES |
38 | GOTERM_MF_FAT | GO:0004970 | ionotropic glutamate receptor activity | 4 | 19 | 1.64E-5 | 2.17E-4 | 0.022359883 |
4 genes
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YES |
39 | GOTERM_MF_FAT | GO:0005234 | extracellular-glutamate-gated ion channel activity | 4 | 20 | 1.92E-5 | 2.37E-4 | 0.026256726 |
4 genes
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YES |
40 | GOTERM_MF_FAT | GO:0005262 | calcium channel activity | 4 | 113 | 0.003330148 | 0.024188161 | 4.450346946 |
4 genes
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YES |
41 | GOTERM_MF_FAT | GO:0015085 | calcium ion transmembrane transporter activity | 4 | 128 | 0.004723773 | 0.032788435 | 6.257693419 |
4 genes
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YES |
42 | KEGG_PATHWAY | hsa04722 | Neurotrophin signaling pathway | 4 | 120 | 0.027715802 | 0.15086102 | 27.8496063 |
4 genes
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YES |
43 | GOTERM_BP_FAT | GO:0006869 | lipid transport | 4 | 317 | 0.045481159 | 0.156033678 | 56.12567291 |
4 genes
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YES |
44 | GOTERM_MF_FAT | GO:0004935 | adrenergic receptor activity | 3 | 16 | 8.07E-4 | 0.006943128 | 1.096403612 |
3 genes
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YES |
45 | GOTERM_MF_FAT | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 3 | 65 | 0.01289272 | 0.069662851 | 16.23022239 |
3 genes
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YES |
46 | KEGG_PATHWAY | hsa05214 | Glioma | 3 | 65 | 0.049309583 | 0.236383531 | 44.41456888 |
3 genes
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YES |
47 | GOTERM_MF_FAT | GO:0022843 | voltage-gated cation channel activity | 3 | 135 | 0.049917455 | 0.209863435 | 50.28388405 |
3 genes
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YES |
48 | GOTERM_BP_FAT | GO:0007586 | digestion | 3 | 167 | 0.066316913 | 0.210997744 | 70.31292206 |
3 genes
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YES |
49 | GOTERM_MF_FAT | GO:0005244 | voltage-gated ion channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
50 | GOTERM_MF_FAT | GO:0022832 | voltage-gated channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
51 | GOTERM_MF_FAT | GO:0004716 | receptor signaling protein tyrosine kinase activity | 2 | 10 | 0.026265383 | 0.128077738 | 30.45869048 |
2 genes
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YES |