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Enriched Pathway by Core Genes
The pathway enrichment analysis for core genes was done by DAVID. The core genes for pathway enrichment analysis included both training genes and prioritized genes from gene prioritization analysis. Gene List
Filter Enriched Pathway
Enriched Pathways (count: 51)
Category
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ID
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Name
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Mapped Gene Count
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Total Gene Count
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P-value
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Benjamini
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FDR
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Genes
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PBA Result?
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---|---|---|---|---|---|---|---|---|---|---|
1 | GOTERM_MF_FAT | GO:0004952 | dopamine neurotransmitter receptor activity | 4 | 7 | 6.05E-7 | 1.49E-5 | 8.26E-4 |
4 genes
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YES |
2 | GOTERM_MF_FAT | GO:0004716 | receptor signaling protein tyrosine kinase activity | 2 | 10 | 0.026265383 | 0.128077738 | 30.45869048 |
2 genes
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YES |
3 | GOTERM_MF_FAT | GO:0004935 | adrenergic receptor activity | 3 | 16 | 8.07E-4 | 0.006943128 | 1.096403612 |
3 genes
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YES |
4 | GOTERM_MF_FAT | GO:0004970 | ionotropic glutamate receptor activity | 4 | 19 | 1.64E-5 | 2.17E-4 | 0.022359883 |
4 genes
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YES |
5 | GOTERM_MF_FAT | GO:0005234 | extracellular-glutamate-gated ion channel activity | 4 | 20 | 1.92E-5 | 2.37E-4 | 0.026256726 |
4 genes
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YES |
6 | GOTERM_BP_FAT | GO:0007194 | negative regulation of adenylate cyclase activity | 5 | 24 | 3.58E-7 | 5.98E-6 | 6.34E-4 |
5 genes
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YES |
7 | GOTERM_MF_FAT | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 3 | 65 | 0.01289272 | 0.069662851 | 16.23022239 |
3 genes
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YES |
8 | KEGG_PATHWAY | hsa05214 | Glioma | 3 | 65 | 0.049309583 | 0.236383531 | 44.41456888 |
3 genes
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YES |
9 | KEGG_PATHWAY | hsa04720 | Long-term potentiation | 6 | 66 | 2.68E-5 | 3.43E-4 | 0.031146966 |
6 genes
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YES |
10 | KEGG_PATHWAY | hsa04540 | Gap junction | 5 | 88 | 0.001302753 | 0.011062431 | 1.502514733 |
5 genes
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YES |
11 | GOTERM_MF_FAT | GO:0005262 | calcium channel activity | 4 | 113 | 0.003330148 | 0.024188161 | 4.450346946 |
4 genes
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YES |
12 | KEGG_PATHWAY | hsa04722 | Neurotrophin signaling pathway | 4 | 120 | 0.027715802 | 0.15086102 | 27.8496063 |
4 genes
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YES |
13 | GOTERM_MF_FAT | GO:0015085 | calcium ion transmembrane transporter activity | 4 | 128 | 0.004723773 | 0.032788435 | 6.257693419 |
4 genes
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YES |
14 | GOTERM_MF_FAT | GO:0016247 | channel regulator activity | 5 | 135 | 4.42E-4 | 0.004002625 | 0.601070764 |
5 genes
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YES |
15 | GOTERM_MF_FAT | GO:0022843 | voltage-gated cation channel activity | 3 | 135 | 0.049917455 | 0.209863435 | 50.28388405 |
3 genes
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YES |
16 | GOTERM_BP_FAT | GO:0007586 | digestion | 3 | 167 | 0.066316913 | 0.210997744 | 70.31292206 |
3 genes
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YES |
17 | KEGG_PATHWAY | hsa04020 | Calcium signaling pathway | 13 | 179 | 9.51E-11 | 3.04E-9 | 1.1E-7 |
13 genes
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YES |
18 | GOTERM_MF_FAT | GO:0005516 | calmodulin binding | 5 | 189 | 0.001550106 | 0.012089995 | 2.094899472 |
5 genes
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YES |
19 | GOTERM_MF_FAT | GO:0005244 | voltage-gated ion channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
20 | GOTERM_MF_FAT | GO:0022832 | voltage-gated channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
21 | GOTERM_BP_FAT | GO:0007565 | female pregnancy | 5 | 205 | 0.001731742 | 0.009463748 | 3.021053466 |
5 genes
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YES |
22 | GOTERM_CC_FAT | GO:0045211 | postsynaptic membrane | 14 | 211 | 1.59E-14 | 3.87E-13 | 2.06E-11 |
14 genes
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YES |
23 | GOTERM_BP_FAT | GO:0006813 | potassium ion transport | 5 | 221 | 0.002276923 | 0.012144819 | 3.954168213 |
5 genes
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YES |
24 | KEGG_PATHWAY | hsa04010 | MAPK signaling pathway | 5 | 255 | 0.050086706 | 0.231326508 | 44.93996299 |
5 genes
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YES |
25 | GOTERM_MF_FAT | GO:0005261 | cation channel activity | 6 | 303 | 0.001186512 | 0.009480121 | 1.607202135 |
6 genes
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YES |
26 | GOTERM_MF_FAT | GO:0005085 | guanyl-nucleotide exchange factor activity | 8 | 307 | 1.45E-5 | 2.0E-4 | 0.019796314 |
8 genes
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YES |
27 | GOTERM_BP_FAT | GO:0006869 | lipid transport | 4 | 317 | 0.045481159 | 0.156033678 | 56.12567291 |
4 genes
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YES |
28 | GOTERM_CC_FAT | GO:0043235 | receptor complex | 13 | 329 | 9.12E-11 | 1.48E-9 | 1.18E-7 |
13 genes
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YES |
29 | GOTERM_MF_FAT | GO:0022836 | gated channel activity | 9 | 332 | 2.17E-6 | 3.95E-5 | 0.002966117 |
9 genes
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YES |
30 | GOTERM_BP_FAT | GO:0006816 | calcium ion transport | 13 | 379 | 9.72E-11 | 4.9E-9 | 1.72E-7 |
13 genes
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YES |
31 | GOTERM_MF_FAT | GO:0046873 | metal ion transmembrane transporter activity | 6 | 421 | 0.004931426 | 0.033535793 | 6.524262892 |
6 genes
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YES |
32 | GOTERM_MF_FAT | GO:0005216 | ion channel activity | 9 | 426 | 1.36E-5 | 2.04E-4 | 0.018528758 |
9 genes
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YES |
33 | GOTERM_MF_FAT | GO:0022838 | substrate-specific channel activity | 9 | 442 | 1.77E-5 | 2.26E-4 | 0.024186209 |
9 genes
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YES |
34 | GOTERM_BP_FAT | GO:0015672 | monovalent inorganic cation transport | 8 | 490 | 2.02E-4 | 0.001405267 | 0.357266676 |
8 genes
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YES |
35 | GOTERM_MF_FAT | GO:0008324 | cation transmembrane transporter activity | 8 | 614 | 0.001055867 | 0.008850036 | 1.431415794 |
8 genes
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YES |
36 | GOTERM_BP_FAT | GO:0007268 | chemical synaptic transmission | 26 | 620 | 1.6E-25 | 4.13E-22 | 2.84E-22 |
26 genes
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YES |
37 | GOTERM_BP_FAT | GO:0006954 | inflammatory response | 7 | 648 | 0.005395144 | 0.02577694 | 9.130517593 |
7 genes
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YES |
38 | GOTERM_MF_FAT | GO:0004672 | protein kinase activity | 6 | 653 | 0.028488647 | 0.136392409 | 32.59462048 |
6 genes
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YES |
39 | GOTERM_BP_FAT | GO:0007420 | brain development | 12 | 717 | 1.1E-6 | 1.55E-5 | 0.001950693 |
12 genes
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YES |
40 | GOTERM_BP_FAT | GO:0000904 | cell morphogenesis involved in differentiation | 10 | 763 | 9.7E-5 | 7.32E-4 | 0.171499021 |
10 genes
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YES |
41 | GOTERM_CC_FAT | GO:0045202 | synapse | 28 | 768 | 1.01E-24 | 2.47E-22 | 1.31E-21 |
28 genes
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YES |
42 | GOTERM_BP_FAT | GO:0030001 | metal ion transport | 17 | 828 | 5.98E-11 | 3.2E-9 | 1.06E-7 |
17 genes
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YES |
43 | GOTERM_BP_FAT | GO:0031175 | neuron projection development | 11 | 851 | 3.81E-5 | 3.2E-4 | 0.06742713 |
11 genes
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YES |
44 | GOTERM_BP_FAT | GO:0007417 | central nervous system development | 14 | 942 | 3.08E-7 | 5.28E-6 | 5.45E-4 |
14 genes
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YES |
45 | GOTERM_BP_FAT | GO:0006812 | cation transport | 17 | 988 | 8.08E-10 | 3.2E-8 | 1.43E-6 |
17 genes
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YES |
46 | GOTERM_MF_FAT | GO:0005102 | receptor binding | 12 | 1464 | 0.001172682 | 0.0095921 | 1.588607405 |
12 genes
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YES |
47 | GOTERM_BP_FAT | GO:0006811 | ion transport | 22 | 1475 | 5.96E-12 | 4.26E-10 | 1.05E-8 |
22 genes
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YES |
48 | GOTERM_CC_FAT | GO:0005887 | integral component of plasma membrane | 23 | 1637 | 6.82E-11 | 1.19E-9 | 8.83E-8 |
23 genes
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YES |
49 | GOTERM_MF_FAT | GO:0004872 | receptor activity | 24 | 1680 | 1.77E-12 | 1.53E-10 | 2.42E-9 |
24 genes
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YES |
50 | GOTERM_MF_FAT | GO:0004871 | signal transducer activity | 24 | 1762 | 4.82E-12 | 2.37E-10 | 6.57E-9 |
24 genes
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YES |
51 | GOTERM_BP_FAT | GO:0007399 | nervous system development | 22 | 2224 | 1.27E-8 | 3.42E-7 | 2.26E-5 |
22 genes
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YES |