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Enriched Pathway by Core Genes
The pathway enrichment analysis for core genes was done by DAVID. The core genes for pathway enrichment analysis included both training genes and prioritized genes from gene prioritization analysis. Gene List
Filter Enriched Pathway
Enriched Pathways (count: 51)
Category
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ID
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Name
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Mapped Gene Count
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Total Gene Count
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P-value
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Benjamini
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FDR
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Genes
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PBA Result?
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1 | GOTERM_MF_FAT | GO:0005244 | voltage-gated ion channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
2 | GOTERM_MF_FAT | GO:0022832 | voltage-gated channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
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YES |
3 | GOTERM_MF_FAT | GO:0022843 | voltage-gated cation channel activity | 3 | 135 | 0.049917455 | 0.209863435 | 50.28388405 |
3 genes
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YES |
4 | GOTERM_MF_FAT | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 3 | 65 | 0.01289272 | 0.069662851 | 16.23022239 |
3 genes
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YES |
5 | GOTERM_CC_FAT | GO:0045202 | synapse | 28 | 768 | 1.01E-24 | 2.47E-22 | 1.31E-21 |
28 genes
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YES |
6 | GOTERM_MF_FAT | GO:0022838 | substrate-specific channel activity | 9 | 442 | 1.77E-5 | 2.26E-4 | 0.024186209 |
9 genes
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YES |
7 | GOTERM_MF_FAT | GO:0004871 | signal transducer activity | 24 | 1762 | 4.82E-12 | 2.37E-10 | 6.57E-9 |
24 genes
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YES |
8 | GOTERM_MF_FAT | GO:0004716 | receptor signaling protein tyrosine kinase activity | 2 | 10 | 0.026265383 | 0.128077738 | 30.45869048 |
2 genes
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YES |
9 | GOTERM_CC_FAT | GO:0043235 | receptor complex | 13 | 329 | 9.12E-11 | 1.48E-9 | 1.18E-7 |
13 genes
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YES |
10 | GOTERM_MF_FAT | GO:0005102 | receptor binding | 12 | 1464 | 0.001172682 | 0.0095921 | 1.588607405 |
12 genes
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YES |
11 | GOTERM_MF_FAT | GO:0004872 | receptor activity | 24 | 1680 | 1.77E-12 | 1.53E-10 | 2.42E-9 |
24 genes
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YES |
12 | GOTERM_MF_FAT | GO:0004672 | protein kinase activity | 6 | 653 | 0.028488647 | 0.136392409 | 32.59462048 |
6 genes
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YES |
13 | GOTERM_BP_FAT | GO:0006813 | potassium ion transport | 5 | 221 | 0.002276923 | 0.012144819 | 3.954168213 |
5 genes
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YES |
14 | GOTERM_CC_FAT | GO:0045211 | postsynaptic membrane | 14 | 211 | 1.59E-14 | 3.87E-13 | 2.06E-11 |
14 genes
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YES |
15 | GOTERM_BP_FAT | GO:0031175 | neuron projection development | 11 | 851 | 3.81E-5 | 3.2E-4 | 0.06742713 |
11 genes
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YES |
16 | GOTERM_BP_FAT | GO:0007399 | nervous system development | 22 | 2224 | 1.27E-8 | 3.42E-7 | 2.26E-5 |
22 genes
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YES |
17 | GOTERM_BP_FAT | GO:0007194 | negative regulation of adenylate cyclase activity | 5 | 24 | 3.58E-7 | 5.98E-6 | 6.34E-4 |
5 genes
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YES |
18 | GOTERM_BP_FAT | GO:0015672 | monovalent inorganic cation transport | 8 | 490 | 2.02E-4 | 0.001405267 | 0.357266676 |
8 genes
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YES |
19 | GOTERM_BP_FAT | GO:0030001 | metal ion transport | 17 | 828 | 5.98E-11 | 3.2E-9 | 1.06E-7 |
17 genes
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YES |
20 | GOTERM_MF_FAT | GO:0046873 | metal ion transmembrane transporter activity | 6 | 421 | 0.004931426 | 0.033535793 | 6.524262892 |
6 genes
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YES |
21 | GOTERM_BP_FAT | GO:0006869 | lipid transport | 4 | 317 | 0.045481159 | 0.156033678 | 56.12567291 |
4 genes
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YES |
22 | GOTERM_MF_FAT | GO:0004970 | ionotropic glutamate receptor activity | 4 | 19 | 1.64E-5 | 2.17E-4 | 0.022359883 |
4 genes
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YES |
23 | GOTERM_BP_FAT | GO:0006811 | ion transport | 22 | 1475 | 5.96E-12 | 4.26E-10 | 1.05E-8 |
22 genes
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YES |
24 | GOTERM_MF_FAT | GO:0005216 | ion channel activity | 9 | 426 | 1.36E-5 | 2.04E-4 | 0.018528758 |
9 genes
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YES |
25 | GOTERM_CC_FAT | GO:0005887 | integral component of plasma membrane | 23 | 1637 | 6.82E-11 | 1.19E-9 | 8.83E-8 |
23 genes
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YES |
26 | GOTERM_BP_FAT | GO:0006954 | inflammatory response | 7 | 648 | 0.005395144 | 0.02577694 | 9.130517593 |
7 genes
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YES |
27 | GOTERM_MF_FAT | GO:0005085 | guanyl-nucleotide exchange factor activity | 8 | 307 | 1.45E-5 | 2.0E-4 | 0.019796314 |
8 genes
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YES |
28 | GOTERM_MF_FAT | GO:0022836 | gated channel activity | 9 | 332 | 2.17E-6 | 3.95E-5 | 0.002966117 |
9 genes
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YES |
29 | GOTERM_BP_FAT | GO:0007565 | female pregnancy | 5 | 205 | 0.001731742 | 0.009463748 | 3.021053466 |
5 genes
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YES |
30 | GOTERM_MF_FAT | GO:0005234 | extracellular-glutamate-gated ion channel activity | 4 | 20 | 1.92E-5 | 2.37E-4 | 0.026256726 |
4 genes
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YES |
31 | GOTERM_MF_FAT | GO:0004952 | dopamine neurotransmitter receptor activity | 4 | 7 | 6.05E-7 | 1.49E-5 | 8.26E-4 |
4 genes
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YES |
32 | GOTERM_BP_FAT | GO:0007586 | digestion | 3 | 167 | 0.066316913 | 0.210997744 | 70.31292206 |
3 genes
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YES |
33 | GOTERM_BP_FAT | GO:0007268 | chemical synaptic transmission | 26 | 620 | 1.6E-25 | 4.13E-22 | 2.84E-22 |
26 genes
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YES |
34 | GOTERM_MF_FAT | GO:0016247 | channel regulator activity | 5 | 135 | 4.42E-4 | 0.004002625 | 0.601070764 |
5 genes
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YES |
35 | GOTERM_BP_FAT | GO:0007417 | central nervous system development | 14 | 942 | 3.08E-7 | 5.28E-6 | 5.45E-4 |
14 genes
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YES |
36 | GOTERM_BP_FAT | GO:0000904 | cell morphogenesis involved in differentiation | 10 | 763 | 9.7E-5 | 7.32E-4 | 0.171499021 |
10 genes
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YES |
37 | GOTERM_BP_FAT | GO:0006812 | cation transport | 17 | 988 | 8.08E-10 | 3.2E-8 | 1.43E-6 |
17 genes
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YES |
38 | GOTERM_MF_FAT | GO:0008324 | cation transmembrane transporter activity | 8 | 614 | 0.001055867 | 0.008850036 | 1.431415794 |
8 genes
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YES |
39 | GOTERM_MF_FAT | GO:0005261 | cation channel activity | 6 | 303 | 0.001186512 | 0.009480121 | 1.607202135 |
6 genes
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YES |
40 | GOTERM_MF_FAT | GO:0005516 | calmodulin binding | 5 | 189 | 0.001550106 | 0.012089995 | 2.094899472 |
5 genes
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YES |
41 | GOTERM_BP_FAT | GO:0006816 | calcium ion transport | 13 | 379 | 9.72E-11 | 4.9E-9 | 1.72E-7 |
13 genes
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YES |
42 | GOTERM_MF_FAT | GO:0015085 | calcium ion transmembrane transporter activity | 4 | 128 | 0.004723773 | 0.032788435 | 6.257693419 |
4 genes
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YES |
43 | GOTERM_MF_FAT | GO:0005262 | calcium channel activity | 4 | 113 | 0.003330148 | 0.024188161 | 4.450346946 |
4 genes
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YES |
44 | GOTERM_BP_FAT | GO:0007420 | brain development | 12 | 717 | 1.1E-6 | 1.55E-5 | 0.001950693 |
12 genes
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YES |
45 | GOTERM_MF_FAT | GO:0004935 | adrenergic receptor activity | 3 | 16 | 8.07E-4 | 0.006943128 | 1.096403612 |
3 genes
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YES |
46 | KEGG_PATHWAY | hsa04722 | Neurotrophin signaling pathway | 4 | 120 | 0.027715802 | 0.15086102 | 27.8496063 |
4 genes
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YES |
47 | KEGG_PATHWAY | hsa04010 | MAPK signaling pathway | 5 | 255 | 0.050086706 | 0.231326508 | 44.93996299 |
5 genes
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YES |
48 | KEGG_PATHWAY | hsa04720 | Long-term potentiation | 6 | 66 | 2.68E-5 | 3.43E-4 | 0.031146966 |
6 genes
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YES |
49 | KEGG_PATHWAY | hsa05214 | Glioma | 3 | 65 | 0.049309583 | 0.236383531 | 44.41456888 |
3 genes
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YES |
50 | KEGG_PATHWAY | hsa04540 | Gap junction | 5 | 88 | 0.001302753 | 0.011062431 | 1.502514733 |
5 genes
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YES |
51 | KEGG_PATHWAY | hsa04020 | Calcium signaling pathway | 13 | 179 | 9.51E-11 | 3.04E-9 | 1.1E-7 |
13 genes
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YES |