
Search SNP
Search Gene
Search CNV
Search Haplotype
Search Other Variant
Search Region
Search Pathway
Search Study
Enriched Pathway by Core Genes
The pathway enrichment analysis for core genes was done by DAVID. The core genes for pathway enrichment analysis included both training genes and prioritized genes from gene prioritization analysis. Gene List
Filter Enriched Pathway
Enriched Pathways (count: 51)
Category
![]() ![]() |
ID
![]() ![]() |
Name
![]() ![]() |
Mapped Gene Count
![]() ![]() |
Total Gene Count
![]() ![]() |
P-value
![]() ![]() |
Benjamini
![]() ![]() |
FDR
![]() ![]() |
Genes
![]() ![]() |
PBA Result?
![]() ![]() |
|
---|---|---|---|---|---|---|---|---|---|---|
1 | GOTERM_MF_FAT | GO:0022832 | voltage-gated channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
![]() |
YES |
2 | GOTERM_MF_FAT | GO:0005244 | voltage-gated ion channel activity | 3 | 191 | 0.091350032 | 0.319069633 | 72.94693154 |
3 genes
![]() |
YES |
3 | KEGG_PATHWAY | hsa05214 | Glioma | 3 | 65 | 0.049309583 | 0.236383531 | 44.41456888 |
3 genes
![]() |
YES |
4 | KEGG_PATHWAY | hsa04010 | MAPK signaling pathway | 5 | 255 | 0.050086706 | 0.231326508 | 44.93996299 |
5 genes
![]() |
YES |
5 | GOTERM_BP_FAT | GO:0007586 | digestion | 3 | 167 | 0.066316913 | 0.210997744 | 70.31292206 |
3 genes
![]() |
YES |
6 | GOTERM_MF_FAT | GO:0022843 | voltage-gated cation channel activity | 3 | 135 | 0.049917455 | 0.209863435 | 50.28388405 |
3 genes
![]() |
YES |
7 | GOTERM_BP_FAT | GO:0006869 | lipid transport | 4 | 317 | 0.045481159 | 0.156033678 | 56.12567291 |
4 genes
![]() |
YES |
8 | KEGG_PATHWAY | hsa04722 | Neurotrophin signaling pathway | 4 | 120 | 0.027715802 | 0.15086102 | 27.8496063 |
4 genes
![]() |
YES |
9 | GOTERM_MF_FAT | GO:0004672 | protein kinase activity | 6 | 653 | 0.028488647 | 0.136392409 | 32.59462048 |
6 genes
![]() |
YES |
10 | GOTERM_MF_FAT | GO:0004716 | receptor signaling protein tyrosine kinase activity | 2 | 10 | 0.026265383 | 0.128077738 | 30.45869048 |
2 genes
![]() |
YES |
11 | GOTERM_MF_FAT | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 3 | 65 | 0.01289272 | 0.069662851 | 16.23022239 |
3 genes
![]() |
YES |
12 | GOTERM_MF_FAT | GO:0046873 | metal ion transmembrane transporter activity | 6 | 421 | 0.004931426 | 0.033535793 | 6.524262892 |
6 genes
![]() |
YES |
13 | GOTERM_MF_FAT | GO:0015085 | calcium ion transmembrane transporter activity | 4 | 128 | 0.004723773 | 0.032788435 | 6.257693419 |
4 genes
![]() |
YES |
14 | GOTERM_BP_FAT | GO:0006954 | inflammatory response | 7 | 648 | 0.005395144 | 0.02577694 | 9.130517593 |
7 genes
![]() |
YES |
15 | GOTERM_MF_FAT | GO:0005262 | calcium channel activity | 4 | 113 | 0.003330148 | 0.024188161 | 4.450346946 |
4 genes
![]() |
YES |
16 | GOTERM_BP_FAT | GO:0006813 | potassium ion transport | 5 | 221 | 0.002276923 | 0.012144819 | 3.954168213 |
5 genes
![]() |
YES |
17 | GOTERM_MF_FAT | GO:0005516 | calmodulin binding | 5 | 189 | 0.001550106 | 0.012089995 | 2.094899472 |
5 genes
![]() |
YES |
18 | KEGG_PATHWAY | hsa04540 | Gap junction | 5 | 88 | 0.001302753 | 0.011062431 | 1.502514733 |
5 genes
![]() |
YES |
19 | GOTERM_MF_FAT | GO:0005102 | receptor binding | 12 | 1464 | 0.001172682 | 0.0095921 | 1.588607405 |
12 genes
![]() |
YES |
20 | GOTERM_MF_FAT | GO:0005261 | cation channel activity | 6 | 303 | 0.001186512 | 0.009480121 | 1.607202135 |
6 genes
![]() |
YES |
21 | GOTERM_BP_FAT | GO:0007565 | female pregnancy | 5 | 205 | 0.001731742 | 0.009463748 | 3.021053466 |
5 genes
![]() |
YES |
22 | GOTERM_MF_FAT | GO:0008324 | cation transmembrane transporter activity | 8 | 614 | 0.001055867 | 0.008850036 | 1.431415794 |
8 genes
![]() |
YES |
23 | GOTERM_MF_FAT | GO:0004935 | adrenergic receptor activity | 3 | 16 | 8.07E-4 | 0.006943128 | 1.096403612 |
3 genes
![]() |
YES |
24 | GOTERM_MF_FAT | GO:0016247 | channel regulator activity | 5 | 135 | 4.42E-4 | 0.004002625 | 0.601070764 |
5 genes
![]() |
YES |
25 | GOTERM_BP_FAT | GO:0015672 | monovalent inorganic cation transport | 8 | 490 | 2.02E-4 | 0.001405267 | 0.357266676 |
8 genes
![]() |
YES |
26 | GOTERM_BP_FAT | GO:0000904 | cell morphogenesis involved in differentiation | 10 | 763 | 9.7E-5 | 7.32E-4 | 0.171499021 |
10 genes
![]() |
YES |
27 | KEGG_PATHWAY | hsa04720 | Long-term potentiation | 6 | 66 | 2.68E-5 | 3.43E-4 | 0.031146966 |
6 genes
![]() |
YES |
28 | GOTERM_BP_FAT | GO:0031175 | neuron projection development | 11 | 851 | 3.81E-5 | 3.2E-4 | 0.06742713 |
11 genes
![]() |
YES |
29 | GOTERM_MF_FAT | GO:0005234 | extracellular-glutamate-gated ion channel activity | 4 | 20 | 1.92E-5 | 2.37E-4 | 0.026256726 |
4 genes
![]() |
YES |
30 | GOTERM_MF_FAT | GO:0022838 | substrate-specific channel activity | 9 | 442 | 1.77E-5 | 2.26E-4 | 0.024186209 |
9 genes
![]() |
YES |
31 | GOTERM_MF_FAT | GO:0004970 | ionotropic glutamate receptor activity | 4 | 19 | 1.64E-5 | 2.17E-4 | 0.022359883 |
4 genes
![]() |
YES |
32 | GOTERM_MF_FAT | GO:0005216 | ion channel activity | 9 | 426 | 1.36E-5 | 2.04E-4 | 0.018528758 |
9 genes
![]() |
YES |
33 | GOTERM_MF_FAT | GO:0005085 | guanyl-nucleotide exchange factor activity | 8 | 307 | 1.45E-5 | 2.0E-4 | 0.019796314 |
8 genes
![]() |
YES |
34 | GOTERM_MF_FAT | GO:0022836 | gated channel activity | 9 | 332 | 2.17E-6 | 3.95E-5 | 0.002966117 |
9 genes
![]() |
YES |
35 | GOTERM_BP_FAT | GO:0007420 | brain development | 12 | 717 | 1.1E-6 | 1.55E-5 | 0.001950693 |
12 genes
![]() |
YES |
36 | GOTERM_MF_FAT | GO:0004952 | dopamine neurotransmitter receptor activity | 4 | 7 | 6.05E-7 | 1.49E-5 | 8.26E-4 |
4 genes
![]() |
YES |
37 | GOTERM_BP_FAT | GO:0007194 | negative regulation of adenylate cyclase activity | 5 | 24 | 3.58E-7 | 5.98E-6 | 6.34E-4 |
5 genes
![]() |
YES |
38 | GOTERM_BP_FAT | GO:0007417 | central nervous system development | 14 | 942 | 3.08E-7 | 5.28E-6 | 5.45E-4 |
14 genes
![]() |
YES |
39 | GOTERM_BP_FAT | GO:0007399 | nervous system development | 22 | 2224 | 1.27E-8 | 3.42E-7 | 2.26E-5 |
22 genes
![]() |
YES |
40 | GOTERM_BP_FAT | GO:0006812 | cation transport | 17 | 988 | 8.08E-10 | 3.2E-8 | 1.43E-6 |
17 genes
![]() |
YES |
41 | GOTERM_BP_FAT | GO:0006816 | calcium ion transport | 13 | 379 | 9.72E-11 | 4.9E-9 | 1.72E-7 |
13 genes
![]() |
YES |
42 | GOTERM_BP_FAT | GO:0030001 | metal ion transport | 17 | 828 | 5.98E-11 | 3.2E-9 | 1.06E-7 |
17 genes
![]() |
YES |
43 | KEGG_PATHWAY | hsa04020 | Calcium signaling pathway | 13 | 179 | 9.51E-11 | 3.04E-9 | 1.1E-7 |
13 genes
![]() |
YES |
44 | GOTERM_CC_FAT | GO:0043235 | receptor complex | 13 | 329 | 9.12E-11 | 1.48E-9 | 1.18E-7 |
13 genes
![]() |
YES |
45 | GOTERM_CC_FAT | GO:0005887 | integral component of plasma membrane | 23 | 1637 | 6.82E-11 | 1.19E-9 | 8.83E-8 |
23 genes
![]() |
YES |
46 | GOTERM_BP_FAT | GO:0006811 | ion transport | 22 | 1475 | 5.96E-12 | 4.26E-10 | 1.05E-8 |
22 genes
![]() |
YES |
47 | GOTERM_MF_FAT | GO:0004871 | signal transducer activity | 24 | 1762 | 4.82E-12 | 2.37E-10 | 6.57E-9 |
24 genes
![]() |
YES |
48 | GOTERM_MF_FAT | GO:0004872 | receptor activity | 24 | 1680 | 1.77E-12 | 1.53E-10 | 2.42E-9 |
24 genes
![]() |
YES |
49 | GOTERM_CC_FAT | GO:0045211 | postsynaptic membrane | 14 | 211 | 1.59E-14 | 3.87E-13 | 2.06E-11 |
14 genes
![]() |
YES |
50 | GOTERM_BP_FAT | GO:0007268 | chemical synaptic transmission | 26 | 620 | 1.6E-25 | 4.13E-22 | 2.84E-22 |
26 genes
![]() |
YES |
51 | GOTERM_CC_FAT | GO:0045202 | synapse | 28 | 768 | 1.01E-24 | 2.47E-22 | 1.31E-21 |
28 genes
![]() |
YES |