BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Meta-analysis Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Goes, F. S.,2012 PMID: 23092984
Citation	Goes, F. S., M. L. Hamshere, et al. (2012). "Genome-wide association of mood-incongruent psychotic bipolar disorder." Transl Psychiatry 2: e180.
Disease Type	Bipolar Disorder
Study Type	Genome-wide association study

Detail Info

Samples	2196 cases with MICP and 8148 controls from NIMH sample,Wellcome Trust Caseâ€“Control Consortium and German sample
Statistic Method	Association analysis of each data set was performed with data set-specific principal components. Meta-analysis was subsequently performed in PLINK under a fixed effect model for both the caseâ€“control and case-only analysis.
Basic Result	We found several regions with suggestive evidence of association (P<10(-6)), although no marker met genome-wide significance criteria. The top associations were on chromosomes: 6q14.2 within the PRSS35/SNAP91 gene complex (rs1171113, P=9.67 x 10(-8)); 3p22.2 downstream of TRANK/LBA1 (rs9834970, P=9.71 x 10(-8)); and 14q24.2 in an intron of NUMB (rs2333194, P=7.03 x 10(-7)). These associations were present in all three samples, and both rs1171113 and rs2333194 were found to be overrepresented in an analysis of MICP cases compared with all other BP cases. To test the relationship of MICP with SZ, we performed polygenic analysis using the Psychiatric GWAS Consortium SZ results and found evidence of association between SZ polygenes and the presence of MICP in BP cases (meta-analysis P=0.003). In summary, our analysis of the MICP phenotype in BP has provided suggestive evidence for association of common variants in several genes expressed in the nervous system. The results of our polygenic analysis provides support for a modest degree of genetic overlap between BP with MICP and SZ, highlighting that phenotypic correlations across syndromes may be due to the influence of polygenic risk factors.

SNPs reported by this study for BD (count: 16)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs3744728			C	OR = 1.51,P-value(Meta) = 0.0000028	Suggestive association was found. Suggestive association was found.	Trend
rs2962370	BASP1		G	OR = 1.19,P-value(Meta) = 0.00000514	Suggestive association was found. Suggestive association was found.	Trend
rs2860031			G	OR = 0.82,P-value(Meta) = 0.00000281	Suggestive association was found. Suggestive association was found.	Trend
rs2333194	NUMB		A	OR = 0.83,P-value(Meta) = 0.000000703	Suggestive association was found. Suggestive association was found.	Trend
rs1930961	CRYBB2P1		C	OR = 0.72,P-value(Meta) = 0.00000949	Suggestive association was found. Suggestive association was found.	Trend
rs1775715	KIF5B		G	OR = 1.18,P-value(Meta) = 0.00000513	Suggestive association was found. Suggestive association was found.	Trend
rs1680005	TMEM217		A	OR = 1.18,P-value(Meta) = 0.00000745	Suggestive association was found. Suggestive association was found.	Trend
rs12617721	INPP4A		C	OR = 1.2,P-value(Meta) = 0.00000745	Suggestive association was found. Suggestive association was found.	Trend
rs11773966	ATP6V1H		A	OR = 2.17,P-value(Meta) = 0.00000192	Suggestive association was found. Suggestive association was found.	Trend
rs1171113	PRSS35		C	OR = 1.23,P-value(Meta) = 0.0000000967	Suggestive association was found. Suggestive association was found.	Trend
rs11710433			C	OR = 0.81,P-value(Meta) = 0.00000116	Suggestive association was found. Suggestive association was found.	Trend
rs10865974	GNL3 PBRM1 SNORD19		T	OR = 0.84,P-value(Meta) = 0.00000218	Suggestive association was found. Suggestive association was found.	Trend
rs10255295	AKR1D1		G	OR = 1.31,P-value(Meta) = 0.00000473	Suggestive association was found. Suggestive association was found.	Trend
rs9834970	TRANK1 LRBA		T	OR = 0.82,P-value(Meta) = 0.0000000971	Suggestive association was found. Suggestive association was found.	Trend
rs3934861	MYOM3		A	OR = 0.8,P-value(Meta) = 0.00000376	Suggestive association was found. Suggestive association was found.	Trend
rs4450798	LINC00620 FBLN2		T	OR = 1.26,P-value(Meta) = 0.00000154	Suggestive association was found. Suggestive association was found.	Trend

Genes reported by this study for BD (count: 10)

Gene	Statistical Values/Author Comments	Result Category
KIF5B	OR = 1.18,P-value(Meta) = 0.00000513 Suggestive association was found. OR = 1.18,P-value(Meta) = 0.00000513 Suggestive association was found.	Trend
NUMB	OR = 0.83,P-value(Meta) = 0.000000703 Suggestive association was found. OR = 0.83,P-value(Meta) = 0.000000703 Suggestive association was found.	Trend
BASP1	OR = 1.19,P-value(Meta) = 0.00000514 Suggestive association was found. OR = 1.19,P-value(Meta) = 0.00000514 Suggestive association was found.	Trend
INPP4A	OR = 1.2,P-value(Meta) = 0.00000745 Suggestive association was found. OR = 1.2,P-value(Meta) = 0.00000745 Suggestive association was found.	Trend
TMEM217	OR = 1.18,P-value(Meta) = 0.00000745 Suggestive association was found. OR = 1.18,P-value(Meta) = 0.00000745 Suggestive association was found.	Trend
CRYBB2P1	OR = 0.72,P-value(Meta) = 0.00000949 Suggestive association was found. OR = 0.72,P-value(Meta) = 0.00000949 Suggestive association was found.	Trend
AKR1D1	OR = 1.31,P-value(Meta) = 0.00000473 Suggestive association was found. OR = 1.31,P-value(Meta) = 0.00000473 Suggestive association was found.	Trend
MYOM3	OR = 0.8,P-value(Meta) = 0.00000376 Suggestive association was found. OR = 0.8,P-value(Meta) = 0.00000376 Suggestive association was found.	Trend
FBLN2	OR = 1.26,P-value(Meta) = 0.00000154 Suggestive association was found. OR = 1.26,P-value(Meta) = 0.00000154 Suggestive association was found.	Trend
ATP6V1H	OR = 2.17,P-value(Meta) = 0.00000192 Suggestive association was found. OR = 2.17,P-value(Meta) = 0.00000192 Suggestive association was found.	Trend