Gene Report

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Basic Info

Approved Symbol	PRSS35
Previous Symbol	C6orf158
Symbol Alias	MGC46520, dJ223E3.1
Approved Name	protease, serine, 35
Previous Name	chromosome 6 open reading frame 158
Location	6q14.2
Position	chr6:83512538-83525704, 1
External Links	HGNC: 21387 Entrez Gene: 167681 Ensembl: ENSG00000146250 UCSC: uc003pjz.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hamshere, M. L.,2009	SNP: rs1171115	the nearest gene of one independently associated SNP rs1171115 that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots)	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0008152	metabolic process	biological process	IEA	50
GO:0003824	catalytic activity	molecular function	IEA	5
GO:0005576	extracellular region	cellular component	IEA	97

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1171115	chr6:83519904 - 83519904(1)	intron_variant	1(0/0/1)
rs1171113	chr6:83516876 - 83516876(1)	intron_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs12528983	chr6:83508775 - 83508775(1)	upstream_gene_variant
rs579599	chr6:83515280 - 83515280(1)	intron_variant
rs6928830	chr6:83509593 - 83509593(1)	upstream_gene_variant
rs1171110	chr6:83515971 - 83515971(1)	intron_variant
rs568129	chr6:83519395 - 83519395(1)	intron_variant
rs680668	chr6:83519647 - 83519647(1)	intron_variant
rs512140	chr6:83520934 - 83520934(1)	intron_variant
rs535787	chr6:83522978 - 83522978(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q14	chr6:75200000-87300000	1 (0/0/1)
6q13-q14	chr6:69200000-87300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:83512538..83525704 View in gBrowse